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[()54.8(4.)-333.3(Moderate)-339.5(Disability:)-335.5(Such)-334.2(a)-330.7(patient)-336(is)-333(able)-335.7(to)-331.8(look)-337.2(after)]TJ .999 -1.1128 TD [(himself)-286.3(at)-283.7(home,)-285.1(to)-281.3(get)-283.2(out)-287.1(and)-285.5(about)-282.2(to)-281.2(the)-283.2(shops)-284.5(and)-285.5(to)-281.3(travel)]TJ 0 -1.1065 TD [(by)-245.6(public)-247.8(transport.)-249.3(However,)-247.5(some)-245.5(previous)-246.6(activities,)-247.9(either)-246.5(at)]TJ 0 -1.1128 TD [(work)-320.1(or)-317.8(in)-319.2(social)-321(life,)-323.8(are)-322.1(now)-318(no)-315.2(longer)-322.3(possible)-318.8(by)-321.5(reason)-321.8(of)]TJ T* [(either)-335(physical)-339(or)-330.4(mental)-335.9(decit)]TJ /F9 1 Tf 13.0505 0 TD (.)Tj /F4 1 Tf .999 0 TD [(.)51.9()]TJ -15.0485 -1.1128 TD [()54.8(5.)-276.4(Good)-279.6(Recovery:)-286.1(This)-275(indicates)-281.7(the)-283.2(capacity)-279.4(to)-281.3(resume)-281.1(normal)]TJ .999 -1.1065 TD [(occupational)-287.8(and)-285.5(social)-283(activities,)-285.8(although)-284.8(there)-287.2(may)-282.7(be)-286(minor)]TJ 0 -1.1128 TD [(physical)-288.4(or)-279.8(mental)-285.4(decits)]TJ /F9 1 Tf 10.6604 0 TD (.)Tj /F4 1 Tf .999 0 TD [(social)-289.3(outcome)-287.2(should)-280.5(be)-286(included)]TJ -11.6595 -1.1128 TD [(in)-331.8(the)-340.1(assessment)-337.1(here,)-330.9(such)-336.8(as)-331.4(leisure)-335.7(activities)-339.8(and)-336.1(family)]TJ T* [(relationships.)51.3()]TJ -.999 -1.1065 TD [(Excerpted)-338.1(from)-335.6(Jennet)-329.6(and)-336.1(Bond)-331.6(\(1975\))]TJ 6.7246 0 0 5.9768 210.2173 532.0062 Tm (1)Tj ET q 468.17 0 0 274.62 73.02 74.041 cm /Im1 Do Q BT /F5 1 Tf 8.9663 0 0 8.9663 62.022 57.2598 Tm [(FIG.)-303.2(1.)]TJ /F4 1 Tf 4.0846 0 TD -.0154 Tc [(GO)-15.4(S)9(E)-299.3(hie)-15.4(r)12.2(ar)-15.4(c)12.2(h)-2.3(y)-305.8(o)4.1(f)-308.4(o)4.1(utc)-15.4(o)14.8(me)-15.4(s)-296.2(\()1.5(adapte)-15.4(d)-288.7(f)-15.4(r)12(o)-2.3(m)-303(M)-3(aa)-15.4(s)-289.9(a)-15.4(n)14.8(d)-305.8(colle)-15.4(a)12.4(gues)]TJ 6.7246 0 0 5.9768 331.5968 61.285 Tm 0 Tc (4)Tj 8.9663 0 0 8.9663 337.5495 57.2598 Tm [(w)16.2(i)15.4(t)15.4(h)-290.4(p)13.1(e)17(r)16.9(m)0(i)25(s)18.3(si)27.4(o)13.1(n)19.5(\))-293(G)16.2(O)16.2(S)14.6(E)13.3(,)-287.4(G)16.2(l)0(a)26.1(s)0(g)31.4(o)13.1(w)-287.3(O)0(u)29.3(t)15.4(co)23.8(m)15.9(e)-286.5(S)14.5(c)0(a)27.8(l)15.4(e-)27.6(E)13.3(x)19.5(te)26.2(n)13.1(d)19.5(ed)23.8(.)]TJ /F3 1 Tf -30.7293 77.2217 TD (2436)Tj 47.093 0 TD [(WILSON)-336.9(ET)-338.7(AL.)]TJ ET endstream endobj 44 0 obj <>stream AdobedC       < s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?Nlٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛6lٳfO5O.h>gcF$k+`}8Cn(v7N uK +͟Z]2&oڐHqFy__ɋmo#FG3sopo|`Ь'K{Fy Ȕi-ITP4iUޡ PӢ3JUڛ*f o_˿v*k< 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[(MANUAL)-341(FOR)-334(THE)-335.2(GOSE)-330.7(INTERVIEW)]TJ 52.4612 0 TD (2437)Tj ET endstream endobj 62 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 70.9795 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(2.)-501.9(GOSE)-439.3(categories)-433.9(\(vegetative)-442.6(state)-435.3([VS])-441.4(to)-433(upper)-438.9(GR\))-432.8(are)]TJ 1.2519 -1.2203 TD [(shown)-330.8(in)-338.2(brackets)-333.6(beside)-335.9(specic)-336.4(responses.)]TJ -1.2519 -1.2266 TD .0161 Tc [(3)16.1(.)-485.8(The)-460(o)-2.4(verall)-461.6(rating)-464(i)-.1(s)-465.1(t)6.2(he)-460(lowest)-461.6(outcome)-460(c)1.5(at)6.2(egory)-457.6(i)-.1(ndi-)]TJ 1.2519 -1.2203 TD .0157 Tc [(cated)-458(by)-451.7(the)-454.1(p)-2.8(ersons)-459.2(a)1.1(nswers)-459.2(\(after)-454.3(discount)5.8(ing)-451.7(limita-)]TJ T* 0 Tc [(t)-16.2(i)-16.2(o)-12.2(n)-12.2(s)-563.4(or)-532.8(prob)18.3(lems)-527.7(bef)15.4(ore)-534.7(inj)18.7(ury\))15.7(.)-540.4(Dea)12.3(ths)-528.5(are)-530.8(tak)14(en)-538.9(fro)15.2(m)]TJ 0 -1.2266 TD [(rec)13(ord)17.8(s,)-250.2(and)-247.5(on)-251.9(the)-245.2(GO)13.3(SE)-250.3(rat)11.4(ing)-242.8(sche)14.9(ma)14(,)-255.8()61.1(VS)70.7()-255(o)0(r)-248.2(a)-254.8(scor)14.7(e)-254.8(o)0(f)]TJ 0 -1.2203 TD [(2)-322(i)0(s)-314.1(the)-308.5(low)13.1(est)-316(cat)17.9(egor)15.9(y)-322(and)-310.8()61.1(Up)14.5(per)-313.4(GR)11.9()61.1()-324.6(or)-311.4(a)-324.4(sco)16.8(re)-320.2(of)-311.4(8)-322(i)0(s)]TJ T* [(the)-466.5(high)16.9(est)12.8(.)-477.1(I)0(f)-472.1(the)-466.5(pers)14.7(on)-473.2(has)-470(no)-473.2(lim)15.2(ita)16.3(tio)12.4(ns)-474.4(or)-469.5(imp)12.9(air)11.4(ing)]TJ 0 -1.2266 TD [(sy)12.4(mpt)12.9(oms)15.7(,)-331.7(the)14(n)-328.3(the)14(ir)-321.8(GOS)15.2(E)-328.1(rat)11.4(ing)-318.7(is)-320.4(Uppe)15.2(r)-324.6(GR.)]TJ /F10 1 Tf -2.251 -12.8039 TD [(Notes)-337.2(to)-330.4(the)-334.8(interview)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-380.1(following)-380.3(notes)-384.6(contain)-382.5(advice)-387.7(for)-376.8(assessors.)-385(Along)-384.3(with)]TJ -1.1128 -1.2203 TD 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Tc [(eliable)-206(r)2.5(epo)5.1(r)-3.8(ting)-203.6(m)1.6(ay)-203.6(be)-206(s)3.9(uggested)-203.6(by)-203.6(lack)-203.6(of)]TJ -9.5223 -1.2203 TD -.0222 Tc [(re)-5.2(al)-6.8(ism)-366.7(i)-.4(n)-363.1(r)-5.3(es)-3.9(pons)-3.9(es)-364.3(or)-365.8(ans)-3.9(w).3(er)-5.3(s)-364.3(t)-.4(hat)-367.2(l)-.4(a)-5.2(c)1.2(k)-363.1(e)-5.2(xpe)-5.2(c)1.2(te)-5.2(d)-363.1(d)-2.7(eta)-5.2(i)-.4(l)-367.2(o)3.6(r)-365.8(a)-5.2(re)-365.6(in-)]TJ T* -.0208 Tc [(consist)-5.4(e)2.6(nt.)-238.7(I)-3.9(nformation)-235.3(c)-3.8(an)-241.6(be)-237.7(obt)]TJ 13.0062 0 TD -.021 Tc [(ai)-5.6(ned)-235.5(f)-4.1(rom)-239(a)-244.2(person)-235.5(w)-4.8(h)4.8(o)-241.8(i).8(s)-243(f)2.2(amiliar)]TJ -13.0062 -1.2203 TD [(wi)-5.7(th)-260.9(the)-263.3(d)-1.6(aily)-267.2(routine)-263.3(o)4.7(f)-263.5(t).7(he)-263.3(patient,)-264.3(s)]TJ 14.4479 0 TD -.0226 Tc [(uc)-5.6(h)-262.4(a)-5.6(s)-263.6(r).6(e)-5.6(l)-.8(ati)-7.2(v)3.2(e)-5.6(s)-263.6(or)-265(clinic)-5.6(al)-266.4(s)-4.3(t)-.8(af)-5.7(f.)]TJ -14.4479 -1.2266 TD -.0216 Tc [(Eligible)-232.2(inform)-5.7(ants)-231(should)-229.8(b)-2.1(e)-232.2(a)-4.6(ge)]TJ /F7 1 Tf 13.0821 0 TD 0 Tc ()Tj /F4 1 Tf .5311 0 TD -.0196 Tc [(18)-227.8(years)-229(a)-2.6(nd)-227.8(be)-223.9(in)-227.8(reg)6.2(u)-.1(lar)-230.4(f)3.6(ace-to-)]TJ -13.6132 -1.2203 TD -.0209 Tc [(face)-402.2(contact)-397.5(w)1.6(ith)-393.5(t)-5.5(h)4.9(e)-402.2(patient)-397.5(\(i.e)]TJ 13.0252 0 TD -.0201 Tc [(.,)-396.1(see)-401.4(t)1.7(hem)-396.2(a)-3.1(t)-396.7(l)1.7(east)-396.7(on)5.7(ce)-395.1(a)-401.4(w)2.4(eek\).)]TJ -13.0252 -1.2203 TD -.0197 Tc [(Always)-279.6(us)4.9(e)-280.9(t)2.1(he)-280.9(best)-276.1(sou)6.1(r)-2.8(ce)-280.9(of)-274.7(in)6.1(fo)6.1(rmation)-278.4(w)2.8(hen)-278.5(a)-2.7(s)4.9(s)-1.4(igning)-278.4(a)-274.5(r)-2.8(atin)6.1(g.)]TJ /F1 1 Tf 1.1128 -10.1925 TD 0 Tc [(b.)-494.8(The)-501.3(rating)-496.4(depends)-493.9(on)-502(change)-495.8(from)-498.6(pre-injury)-498(func-)]TJ -1.1128 -1.2203 TD (tion.)Tj /F4 1 Tf 2.8832 0 TD -.0149 Tc 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[(T)13.3(h)13.1(e)-387.6(p)19.5(u)13.1(r)0(p)30(o)13.1(s)18.3(e)-393.9(o)19.5(f)-387.8(th)28.6(es)29(e)-387.6(q)13.1(u)13.1(e)17(st)27.4(i)15.4(o)13.1(n)19.5(s)-392.7(i)15.4(s)-386.4(t)15.4(o)-391.5(c)17(o)13.1(n)13.1()20.9(rm)-378.2(t)15.4(h)13.1(a)17(t)-389.2(t)15.4(h)13.1(e)-387.6(l)15.4(e)17(v)13.1(el)-372.2(o)13.1(f)-387.8(r)16.9(e)0(-)]TJ 0 -1.2203 TD [(st)27.4(r)16.9(i)15.4(ct)26.2(i)15.4(o)13.1(n)-227.1(r)16.9(ep)30.2(re)27.6(se)29(n)13.1(t)15.4(s)-228.3(a)-229.6(c)17(h)13.1(a)17(n)13.1(g)13.1(e)-229.6(w)16.2(i)15.4(t)15.4(h)-227.1(re)27.6(sp)25.1(e)17(c)17(t)-231.2(t)15.4(o)-227.1(t)15.4(h)13.1(e)-229.6(p)13.1(r)16.9(e)0(-)27.6(t)15.4(r)16.9(a)0(u)30.2(m)0(a)-220(s)18.3(i)15.4(t)15.4(u)13.1(a)17(t)0(i)24.6(o)19.5(n)13.1(.)]TJ /F1 1 Tf 29.1107 61.5535 TD [(c.)-679.6(Capability)-678.4(is)-679.4(considered)-682.2(as)-674.2(well)-684.1(as)-674.2(actual)-677.2(perfor-)]TJ -1.1128 -1.2203 TD (mance.)Tj /F4 1 Tf 4.2743 0 TD [(The)-399.1(interview)-404.1(covers)-404(common)-398.6(activities)-403(and)-399.3(abilities,)]TJ -4.2743 -1.2266 TD [(and)-298.1(in)-293.9(many)-301.2(instances)-297.8(simply)-294.4(nding)-296.9(out)-293.4(whether)-295.9(the)-295.8(person)-300.4(per-)]TJ 0 -1.2203 TD [(forms)-317.3(the)-314.8(activities)-320.8(is)-314.1(sufcient.)-317.3(However,)-317(sometimes)-315.1(it)-316.9(is)-314.1(neces-)]TJ T* [(sary)-206.6(to)-199.1(judge)-200(whether)-201(the)-201(person)-205.6(is)-200.2(able)-196.6(to)-205.4(perform)-200(an)-197.4(activity,)-203.3(even)]TJ 0 -1.2266 TD [(if)-283.9(they)-282.7(do)-277.2(not)-280.8(engage)-288.9(in)-274.9(it)-285.3(in)-281.2(daily)-279.9(life.)-285.9(Financial)-279.1(or)-279.8(practical)-285.5(con-)]TJ 0 -1.2203 TD [(straints,)-404.2(for)-402.1(example,)-400(might)-401.2(be)-399.8(a)-400.3(reason)-404(why)-400.2(a)-400.3(person)-401.6(does)-400(not)]TJ T* [(engage)-269.9(in)-268.6(an)-267(activity,)-266.5(but)-268.1(this)-266.5(does)-267.2(not)-268.1(render)-266.4(the)-270.5(person)-268.8(disabled.)]TJ 0 -1.2266 TD [(On)-286.9(the)-276.9(other)-284.8(hand,)-281.6(the)-283.2(person)-281.5(would)-276.8(be)-286(considered)-282.1(disabled)-282(if)-283.9(the)]TJ 0 -1.2203 TD [(limitation)-309.7(is)-301.4(a)-299.1(result)-302.2(of)-305.1(physical)-301(or)-305.1(mental)-298(impairment)-306.2(from)-304(brain)]TJ T* (injury.)Tj /F1 1 Tf 1.1128 -10.5213 TD [(d.)-362(Consistency)-360.5(between)-363.6(responses)-357.9(is)-363.2(important.)]TJ /F4 1 Tf 22.5728 0 TD [(The)-310.6(re-)]TJ -23.6856 -1.2266 TD [(sponses)-369.3(to)-369.8(the)-365.4(separate)-374(sections)-365.4(should)-369(generally)-367.6(be)-368.2(hierarchical)]TJ 0 -1.2203 TD [(\(e.g.,)-252.6(if)-252.2(a)-248.5(person)-256.2(indicates)-250.1(that)-255.1(they)-251.1(require)-250.9(assistance)-256.7(in)-249.6(the)-251.6(home,)]TJ T* [(then)-358.6(it)-361.1(is)-352(potentially)-361(inconsistent)-358.9(if)-359.7(they)-352.2(answer)-363.1(that)-356.3(they)-358.6(go)-353.1(out)]TJ 0 -1.2266 TD [(alone)-221.4(for)-218.7(social)-219.8(and)-215.9(leisure)-221.9(activities\).)-218.4(It)-220.6(would)-213.5(also)-220.6(be)-216.4(inconsistent)]TJ 0 -1.2203 TD [(if)-328.1(the)-321.1(person)-319.4(reported)-326.3(that)-324.7(they)-320.6(were)-324.9(unable)-322.1(to)-319.2(work,)-323(but)-325(also)-321.8(re-)]TJ T* [(ported)-322.3(that)-318.3(they)-320.6(had)-317.1(no)-321.5(symptoms.)-316(Thus,)-318.1(responses)-322.8(to)-319.2(later)-316.5(ques-)]TJ T* [(tions)-209.1(may)-213.1(suggest)-207.7(revisions)-207.1(to)-211.7(earlier)-206.8(responses.)-211.9(The)-209.4(opportunity)-205.3(to)]TJ 0 -1.2266 TD [(check)-466.4(consistency)-461.2(is)-459.5(one)-456.2(of)-463.2(the)-453.9(reasons)-461.6(that)-463.8(it)-456(is)-459.5(important)-458.8(to)]TJ 0 -1.2203 TD [(complete)-286.8(the)-276.9(whole)-285.5(interview.)]TJ /F3 1 Tf 0 -9.4844 TD [(Sections)-337.9(of)-336.6(the)-334.6(Interview)]TJ /F10 1 Tf 0 -1.8336 TD (Consciousness)Tj /F5 1 Tf 1.1128 -1.8336 TD [(Q1:)-181.7(Is)-184.8(the)]TJ /F4 1 Tf 4.2616 0 TD (head-injured)Tj /F5 1 Tf 5.2543 0 TD [(person)-183.6(able)-186.4(to)-178.7(obey)-182.4(simple)-180.1(commands,)]TJ -10.6288 -1.2267 TD [(or)-286(say)-277.9(any)-281.7(words?)]TJ /F4 1 Tf 1.1128 -1.2203 TD [(The)-449.7(rst)-440.7(question)-450.3(is)-440.5(intended)-445.3(for)-446.3(patients)-450.5(who)-444.4(are)-442.3(alive)-446.7(but)]TJ -1.1128 -1.2203 TD [(cannot)-379(be)-374.5(interviewed)-380.3(because)-374.2(they)-377.5(cannot)-372.7(respond)-375.8(to)-376.1(questions)]TJ T* [(verbally)-353(or)-349.4(in)-350.8(writing.)-346.3(The)-348.5(rule)-354.9(of)-343.1(thumb)-352.9(that)-349.9(is)-345.7(used)-349.4(to)-350.8(identify)]TJ 0 -1.2266 TD [(patients)-418.9(in)-420.4(a)-412.9(V)0(S)-418.2(\(i.e.,)-421(awake)-419.1(but)-413.5(with)-420.4(no)-410(sign)-420.6(of)-412.6(awareness\))-426.7(is)]TJ 0 -1.2203 TD [(whether)-441.3(or)-431.6(not)-432.5(they)-440.8(can)-433.3(obey)-436.7(commands)-432.8(or)-431.6(say)-438.4(any)-437.2(words.)-431.2(In)]TJ T* [(practice,)-303.9(the)-302.1(question)-298.6(of)-298.8(whether)-295.9(the)-302.2(person)-300.5(is)-295.1(considered)-301(vegeta-)]TJ 0 -1.2266 TD [(tive)-274.1(can)-262.6(usually)-273.8(be)-267(answered)-269.7(best)-264.9(by)-270.9(staff)-263.3(caring)-274.1(for)-263(the)-270.5(patient;)-269.9(if)]TJ 0 -1.2203 TD [(possible,)-283.7(a)-280.1(full)-280.6(assessment)-286.6(is)-282.4(recommended)-279.5(\(see)-284.9(below\).)]TJ /F1 1 Tf 1.1128 -11.7669 TD [(Full)-566.8(assessment)-571(of)-564.4(patients)-571.3(in)-564.1(vegetative)-568.9(or)-563(minimally)]TJ -1.1128 -1.2266 TD [(conscious)-246.7(state.)]TJ /F4 1 Tf 8.1249 0 TD [(A)-192.5(full)-192.1(assessment)-198(of)-191.3(patients)-197.5(in)-192.7(a)-191.6(V)0(S)-190.6(o)0(r)-191.3(MCS)-198.6(is)]TJ -8.1249 -1.2203 TD [(a)-210.6(specialized)-209.7(process)-208.7(requiring)-201(detailed)-211.4(tests)-206.4(of)-204(responsiveness.)-210.7(For)]TJ T* [(example,)-248.3(the)-238.9(Coma)-242.7(Recovery)-244.6(Scale-Revised)]TJ 6.7246 0 0 5.9768 472.9322 72.2267 Tm (14)Tj 8.9663 0 0 8.9663 481.8329 68.2583 Tm [(includes)-244.1(criteria)-248.2(for)]TJ -18.8233 -1.2267 TD [(identifying)-546.9(patients)-545.3(in)-540.5(the)-542.4(VS,)-541.3(and)-538.4(these)-545.1(can)-540.8(be)-545.2(followed)-537.3(in)]TJ ET 62.022 155.679 239.131 .51022 re f 62.022 57.26 239.131 .51025 re f 62.022 57.26 .51024 98.929 re f 300.642 57.26 .51022 98.929 re f BT /F5 1 Tf 8.9663 0 0 8.9663 77.9527 142.9795 Tm [(Notes)-285.3(for)-281.8(assessors)]TJ /F4 1 Tf 0 -1.2203 TD [(Sometimes)-344.1(it)-335.9(can)-344.8(be)-336.6(difcult)-340.6(to)-338.2(establish)-343.7(whether)-340.1(a)-337(person)]TJ -1.1065 -1.2203 TD [(could)-200(do)-201.4(an)-203.8(activity)-200.4(before)-203.1(injury:)-200.9(In)-204(this)-203.3(case,)-205.4(it)-196.8(is)-206.6(easiest)-203.9(to)-199.1(ask)]TJ 0 -1.2266 TD [(the)-276.9(person)-281.5(what)-279.7(has)-286.7(changed)-282(since)-279.5(the)-283.2(injury.)]TJ 1.1065 -1.2203 TD [()54.8(Current)52.4()-311.9(status)-319.7(includes)-313.7(problems)-313.4(and)-317.1(limitations)-310.4(evident)]TJ -1.1065 -1.2203 TD [(over)-331.9(the)-327.4(past)-334.5(week)-335(or)-330.4(so.)-331.9(If)-333(the)-333.8(person)-332.1(reports)-331.9(problems/limi-)]TJ 0 -1.2266 TD [(tations)-233.6(longer)-233.7(ago)-234.9(than)-232.1(this,)-231.5(then)-238.4(you)-232.5(may)-232.1(need)-236.8(to)-230.7(establish)-236.2(that)]TJ 0 -1.2203 TD [(these)-279.5(problems)-281.7(are)-284.2(still)-280.4(present.)]TJ ET 62.022 619.994 239.131 .51025 re f 62.022 545.669 239.131 .51025 re f 62.022 545.669 .51024 74.835 re f 300.642 545.669 .51022 74.835 re f BT /F5 1 Tf 8.9663 0 0 8.9663 77.9527 607.2943 Tm [(Note)-284.6(for)-281.8(assessors)]TJ /F4 1 Tf T* [(Working)-220.1(through)-218.2(the)-213.6(interview,)-223.7(the)-213.6(lowest)-220.7(outcome)-217.6(category)]TJ -1.1065 -1.2203 TD [(is)-345.7(usually)-356(determined)-351.7(by)-353.1(the)-346.4(rst)-352.2(section)-352.1(in)-350.8(which)-355.1(the)-346.4(person)]TJ 0 -1.2266 TD [(reports)-325.6(problems)-332.3(or)-324.1(limitations.)-332.3(Particular)-328(care)-330.4(is)-326.7(needed)-333.1(here)]TJ 0 -1.2203 TD [(when)-319.9(interviewing,)-321.1(given)-320.1(that)-318.3(the)-321.1(overall)-321.9(rating)-320(is)-320.4(determined)]TJ T* [(by)-277.2(their)-282.5(responses.)]TJ ET 62.022 328.592 239.131 .51022 re f 62.022 272.693 239.131 .51022 re f 62.022 272.693 .51024 56.409 re f 300.642 272.693 .51022 56.409 re f BT /F5 1 Tf 8.9663 0 0 8.9663 77.9527 315.8928 Tm [(Note)-284.6(for)-281.8(assessors)]TJ /F4 1 Tf T* [(If)-352(in)-350.8(doubt)-349.3(about)-351.8(respondent)-355.5(reliability,)-351.6(obtain)-355.3(information)]TJ -1.1065 -1.2203 TD [(from)-278.7(a)-280.1(surrogate.)-285.7(Multiple)-280.9(sources)-284.6(of)-279.8(information)-283.4(can)-281.6(be)-279.6(com-)]TJ 0 -1.2266 TD [(bined)-275.9(to)-281.3(determine)-282.6(an)-279.6(overall)-283.9(rating.)]TJ ET 313.058 193.663 239.131 .51024 re f 313.058 127.842 239.131 .51022 re f 313.058 127.842 .51025 66.331 re f 551.679 127.842 .51019 66.331 re f BT /F5 1 Tf 8.9663 0 0 8.9663 329.0456 180.9638 Tm (Skipping)Tj /F4 1 Tf 0 -1.2203 TD [(If)-364.6(the)-365.4(person)-370(is)-364.6(obviously)-365.2(more)-367(than)-364.9(minimally)-368.9(conscious,)]TJ -1.1128 -1.2203 TD [(then)-181.5(Question)-181.8(1)-176.6(i)0(s)-181.3(skipped;)-184.8(start)-182.5(from)-177.5(Question)-181.8(2.)-179.5(If)-181.3(the)-182(person)-180.3(is)]TJ 0 -1.2266 TD [(in)-205.4(a)-210.6(V)0(S)-209.6(o)0(r)-210.3(minimally)-210.9(conscious)-209.2(state)-214(\()-84.3(MCS\),)-209.9(then)-206.8(the)-213.6(rest)-204.3(of)-210.3(the)]TJ 0 -1.2203 TD [(interview)-284(is)-276.1(skipped.)]TJ ET 313.058 603.553 239.131 .51025 re f 313.058 548.22 239.131 .51025 re f 313.058 548.22 .51025 55.843 re f 551.679 548.22 .51019 55.843 re f BT /F5 1 Tf 8.9663 0 0 8.9663 329.0456 590.8534 Tm [(Note)-278.3(for)-281.8(assessors)]TJ /F4 1 Tf T* [(You)-286.4(may)-282.7(need)-287.4(to)-287.6(ask)-286.7(follow-up)-284(questions)-286.7(to)-287.6(establish)-286.8(capa-)]TJ -1.1128 -1.2203 TD [(bility.)-376.5(Could)-379.3(they)-377.5(do)-378.4(the)-378(activity)-377.4(if)-378.7(it)-380.1(were)-381.8(really)-379.3(necessary?)]TJ 0 -1.2266 TD [(What)-278.3(is)-282.4(it)-278.9(that)-286.7(prevents)-280.6(performance?)]TJ ET 313.058 408.246 239.131 .51025 re f 313.058 364.535 239.131 .51025 re f 313.058 364.535 .51025 44.22 re f 551.679 364.535 .51019 44.22 re f BT /F5 1 Tf 8.9663 0 0 8.9663 329.0456 395.5464 Tm [(Note)-278.3(for)-281.8(assessors)]TJ /F4 1 Tf 0 -1.2203 TD [(If)-257.1(responses)-265.9(are)-265.2(inconsistent,)-260.6(you)-264.1(may)-257.4(need)-268.4(to)-256(go)-264.6(back)-262.1(to)-262.3(an)]TJ -1.1128 -1.2203 TD [(earlier)-282.6(point)-277.5(of)-286.2(the)-276.9(interview)-284(to)-281.2(question)-279.6(further.)]TJ /F3 1 Tf -28.6681 41.9335 TD (2438)Tj 47.093 0 TD [(WILSON)-336.9(ET)-338.7(AL.)]TJ ET endstream endobj 68 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(deciding)-186(how)-185.2(the)-182(person)-180.3(is)-181.3(categorized)-188.1(on)-182.4(the)-182(GOSE.)-183(Visual)-182.7(pursuit)]TJ 0 -1.2203 TD [(\(also)-197.5(known)-196.9(as)-192.3()54.8(tracking)53.7(\))-200.2(is)-193.9(a)-191.6(specic)-197.3(aspect)-199.2(that)-198.2(has)-191.8(given)-200(rise)-191.6(to)]TJ 0 -1.2266 TD [(differences)-428.3(in)-420.4(classication)-431.4(in)-420.4(the)-422.3(past.)-419.6(Although)-424.8(the)-422.3(eyes)-421.4(may)]TJ 0 -1.2203 TD [(eetingly)-365.2(turn)-365.1(to)-363.4(follow)-365.1(or)-362(xate)-365.4(on)-359.4(an)-368.2(object,)-360.6(neither)-366.1(sustained)]TJ T* [(visual)-445(xation)-435.6(nor)-443.7(sustained)-440.8(pursuit)-438.4(are)-442.3(observed)-441(in)-439.3(a)-438.2(VS.)-440.1(For)]TJ 0 -1.2266 TD [(further)-276.4(details)-280.2(concerning)-274.6(the)-276.9(criteria)-279.9(for)-275.6(VS)-272.8(and)-272.8(MCS,)-277.3(please)-275.1(see)]TJ 0 -1.2203 TD [(Giacino)-234.1(and)-222.3(colleagues)]TJ 6.7246 0 0 5.9768 143.3196 663.9872 Tm (15)Tj 8.9663 0 0 8.9663 152.0504 660.0187 Tm [(and)-228.6(Kondziella)-232.7(and)-222.3(colleagues)]TJ 6.7246 0 0 5.9768 261.6377 663.9872 Tm (16)Tj 8.9663 0 0 8.9663 270.4251 660.0187 Tm (Patients)Tj -23.4959 -1.2203 TD [(who)-280(fulll)-282.2(criteria)-286.2(for)-282(MCS)-280.7(are)-277.9(rated)-280.9(as)-280.8(Lower)-283.9(SD.)]TJ /F10 1 Tf 0 -14.3783 TD [(Independence)-338.1(in)-330.2(the)-334.8(home)]TJ /F5 1 Tf 1.1128 -1.8336 TD [(Q2a.)-378(Is)-374.5(the)-375.2(assistance)-375.5(of)-374.7(another)-380.6(person)-373.3(at)-374.7(home)-374.2(essential)]TJ -1.1128 -1.2266 TD [(every)-283(day)-281.7(for)-281.8(some)-282(activities)-284(of)-279.8(daily)-276.1(living?)]TJ /F4 1 Tf 1.1128 -1.2203 TD [(Dependence)-301.4(here)-296.3(means)-298(that)-293(assistance)-300.9(is)-295.1(essential)-295.5(for)-300.9(the)-295.8(per-)]TJ -1.1128 -1.2203 TD [(son)-214.7(on)-207.7(a)-210.6(daily)-210.4(basis.)-211.6(The)-209.4(types)-207.5(of)-210.3(activity)-213(that)-210.8(are)-214.6(relevant)-210(are)-214.6(those)]TJ 0 -1.2267 TD [(that)-337.3(are)-341.1(necessary)-339(for)-332.5(independence.)-342(Assistance)-339.7(may)-333.3(be)-336.6(essential)]TJ 0 -1.2203 TD [(when)-345.2(there)-344.1(is)-345.7(actual)-341.2(help)-345.9(\(by)-342.6(another)-343.2(person\))-340.5(with)-344.5(an)-342.9(activity)-345.8(or)]TJ T* [(there)-331.5(is)-326.7(a)-330.7(need)-325.3(for)-326.2(supervision,)-329.1(or)-330.4(the)-327.4(person)-325.7(needs)-332.4(prompting)-325.9(or)]TJ T* [(reminding)-353.6(to)-344.5(do)-346.8(a)-349.7(task.)-350(Although)-342.6(dependency)-352.6(may)-345.9(be)-349.2(caused)-353.3(by)]TJ 0 -1.2266 TD .0164 Tc [(ph)4.2(ys)3.1(ical)-347.5(imp)4.2(a)1.8(irment,)-346.9(a)1.8(fter)-346.1(a)-345.9(T)-1.9(B)5.8(I)1.6(,)-346.9(t).2(he)-345.9(n)4.2(e)1.8(ed)-343.5(fo)4.2(r)-346.1(a)-4.5(s)3.1(s)3.1(i).2(s)3.1(t).2(ance)-345.9(often)]TJ 0 -1.2203 TD .0148 Tc [(a)-6.1(r)0(ises)-283.1(from)-279.1(m)-.9(ental)-279.6(c).2(hanges)-283.1(alone)-6.1(.)]TJ /F1 1 Tf 1.1128 -10.6731 TD 0 Tc [(Follow-up)-471.1(questions.)]TJ /F4 1 Tf 10.319 0 TD .0112 Tc [(A)-4.3(f)2.8(ter)-414.5(a)-3.4(sking)-418.3(t)1.3(he)-414.4(main)-411.9(questi)-5(o)11.2(n)-6.8(,)-415.4(the)]TJ -11.4318 -1.2203 TD .0123 Tc [(ass)5.3(e)-2.3(ss)5.3(or)-394.5(can)-398.2(g)12.3(i)-9.7(v)12.3(e)-400.1(t)-3.9(h)12.3(e)-406.5(p)12.3(e)-8.1(rson)-391.9(examples)-393.1(\(s)5.3(ome)-394.3(a)4(re)-394.3(listed)-391.9(o).1(n)-391.9(t)2.4(he)]TJ 0 -1.2266 TD .0121 Tc [(in)12.1(t)-9.9(e)3.8(rview)-249.9(s)-1.2(ch)12.1(e)-8.3(dule;)-250.7(see)-249.1(S)-5(u)12.1(p)-5.9(plem)]TJ 13.4868 0 TD .014 Tc [(en)14(t)-8(a)5.8(ry)-244.7(Ma)5.8(te)5.8(ria)5.8(l)-2.2(s)7(,)-248.2(Ap)14(pend)14(i)-8(x)-244.7(S1\))5.6(,)]TJ -13.4868 -1.2203 TD .0121 Tc [(t)-4.1(o)-183.4(make)-185.8(clear)-186(t)2.2(he)-185.8(kinds)-184.6(of)-186(act)-4.1(i)2.2(vities)-184.6(t)-4.1(h)12.1(a)-8.3(t)-187.4(a)3.9(re)-185.8(mean)12.1(t)-9.9(.)-180.5(The)-185.8(f)-2.7(ocus)-184.6(i)-4.1(s)-184.6(on)]TJ T* .0108 Tc [(i)-5.4(s)3.8(sues)-400.9(of)-396(safety)-399.7(and)-393.4(m)-4.9(eeting)-399.7(n)10.8(e)-9.6(e)]TJ 13.98 0 TD .011 Tc [(d)11(s)-406.5(in)-393.2(daily)-399.5(life:)-397.2(Will)-397.2(they)-393.2(get)]TJ -13.98 -1.2266 TD [(w)-4.5(a)2.8(shed)-273(and)-273(d)-1.2(ressed)11(,)-282.3(a)2.8(nd)-273(w)-4.5(ill)-270.7(t)-5.2(h)-1.2(ey)-273(eat?)-275.5(Will)-277.1(they)-273(do)-273(this)-274.2(w)-4.5(i)1.1(thou)11(t)]TJ 0 -1.2203 TD .0117 Tc [(pro)11.7(m)-9.8(pting?)-319(Are)-319(t)1.8(hey)-322.9(s)4.7(afe?)-319(\(e.g.,)-320(Are)-319(t)1.8(hey)-316.6(a)-2.9(t)-314.3(r)-3.1(isk)-316.6(o)-.5(f)-319.2(b)-.5(u)11.7(r)-8.9(ning)-316.6(the)]TJ T* [(house)-255.8(down?\);)-257.4(Can)-253.4(t)-4.5(h)11.7(e)-8.7(y)-259.7(h)11.7(a)-8.7(ndle)-255.8(s)-1.6(mall)-257.4(emergencies)4.7(?)-262.1(\(e.g.,)-256.8(a)-262.1(g)11.7(l)-10.3(a)3.4(ss)]TJ T* .0125 Tc [(is)-209.5(d)12.5(r)-8.1(opp)12.5(e)-7.9(d)-208.3(an)12.5(d)-220.5(b)12.5(r)-8.1(oken,)-211.7(a)-204.4(t)-3.7(ap)-208.3(is)-209.5(left)-206(runn)12.5(i)-9.5(n)12.5(g)-220.5(c)4.3(aus)5.5(i)2.6(ng)-208.3(a)-210.7()1.8(ood,)-205.4(a)-210.7(l)-3.7(igh)12.5(t)]TJ 0 -1.2266 TD .012 Tc [(goes)-311.2(o)-.2(u)12(t)-10(,)-307.1(i)-4.2(t)-307.7(b)-.2(eg)12(i)-10(n)12(s)-323.3(t)2.1(o)-310(g)-.2(et)-314(co)12(l)-10(d)-.2(,)-307.1(o)-.2(r)-312.6(a)-312.4(stranger)-312.6(c)-2.6(o)12(m)-9.5(es)-311.2(to)-310(the)-312.4(doo)12(r)-8.6(\))3.6(.)]TJ 0 -1.2203 TD [(Establish)-297.4(t)2(hat)-295.1(t)2(hey)-297.4(c)3.7(ould)-297.4(c)-2.7(are)-299.9(f)3.5(or)-300(thems)4.9(e)-2.7(lves,)-300.8(i)2(f)-300(n)11.9(e)-8.5(c)-2.7(essary)11.9(,)-306.7(f)3.5(or)-300(a)]TJ T* .0122 Tc [(24-h)-284.5(p)12.2(e)-8.2(r)3.8(iod)12.2(.)]TJ 1.1128 -1.2266 TD 0 Tc [(If)-244.5(help)-251.1(is)-244.5(needed,)-247.5(then)-244.8(ask:)]TJ /F8 1 Tf 10.9766 0 TD [(What)-244.5(kinds)-245.5(of)-243.3(things)-246.6(do)-245.6(you)-247.5(get)-251.6(help)]TJ -12.0894 -1.2203 TD (with)Tj /F4 1 Tf 1.7325 0 TD [(?)-305.4(Sometimes)-306.2(assistance)-307.2(is)-307.7(reported)-307.3(for)-307.2(activities)-308.2(like)-305.7(taking)-304.7(a)]TJ -1.7325 -1.2203 TD [(shower,)-490(or)-494.8(non-personal)-489.9(activities)-491.6(such)-488.5(as)-489.5(washing)-494.4(clothes,)-487.8(or)]TJ 0 -1.2266 TD [(household)-211.9(cleaning)-213.7(tasks.)-211.6(These)-218.4(do)-207.7(not)-211.2(count)-212.7(here,)-210.7(because)-216.1(they)-213.1(do)]TJ 0 -1.2203 TD [(not)-331.3(need)-338(to)-331.8(be)-330.2(done)-335.6(every)-333.8(day)-329.7(\(e.g.,)-334.8(showering\))-333.7(and)-329.7(thus)-332(are)-334.8(not)]TJ T* [(essential)-289.2(for)-275.6(independence)-288.5(in)-274.9(daily)-286.2(life.)]TJ 1.1128 -1.2266 TD [(Establish)-265.2(whether)-257.9(they)-257.4(are)-265.2(incapable)-259.9(of)-260.9(the)-257.9(activity.)-260.2(Could)-259.2(they)]TJ -1.1128 -1.2203 TD [(perform)-200(the)-201(activity)-200.4(if)-201.7(they)-200.5(really)-195.9(needed)-200.3(to?)-201(Could)-196(they)-200.5(manage)-203.9(on)]TJ T* [(their)-320.4(own)-311.7(if)-315.5(need)-312.7(be?)-313.2(If)-320.4(they)-314.3(can,)-309.8(then)-314.3(assistance)-319.9(is)-314.1(not)-312.4(essential.)]TJ T* [(Record)-255.8(responses)-253.2(based)-256.5(on)-251.9(the)-251.6(ability)-249(of)-254.5(the)-251.6(patient)-253.8(to)-249.6(perform)-256.9(the)]TJ 0 -1.2266 TD [(activity)-301.5(and)-298.1(not)-293.4(whether)-302.2(the)-295.8(patient)-298(actually)-299.9(performs)-301.9(the)-295.8(activity)]TJ 0 -1.2203 TD (currently.)Tj 29.117 63.8993 TD [(Many)-260.4(persons)-269.5(receive)-272.1(assistance)-269.3(in)-262.3(the)-264.2(sense)-270.3(of)-267.2(companionship)]TJ -1.1128 -1.2203 TD [(or)-235.6(protection.)-238.8(The)-241(person)-237.2(may)-238.4(well)-239.4(benet)-238.5(from)-234.4(this)-241.2(help,)-235(but)-236.5(such)]TJ T* [(care)-330.4(does)-324.1(not)-325(mean)-328.9(that)-324.6(they)-327(are)-328.4(dependent)-329.3(in)-325.5(the)-327.4(sense)-333.6(required)]TJ 0 -1.2266 TD [(here.)-280.3(The)-285.3(need)-281.1(for)-281.9(supervision)-288.3(for)-281.9(safety)-281.6(reasons)-284.6(should)-280.5(be)-286(attrib-)]TJ 0 -1.2203 TD [(utable)-281.8(to)-281.3(objective)-280.5(danger,)-279.3(rather)-283(than)-282.7()54.8(just)-281.3(in)-281.2(case.)51.7()]TJ 1.1128 -1.2203 TD [(Circumstances)-220.6(may)-219.5(mean)-215.1(that)-223.5(the)-213.6(person)-218.3(is)-219.2(never)-220(left)-219.8(alone.)-218(It)-220.6(is)]TJ -1.1128 -1.2203 TD [(not)-312.4(necessary)-313.8(that)-318.3(the)-314.8(person)-313.1(is)-314.1(actually)-312.6(left)-314.6(alone,)-312.8(only)-318.2(that)-312(they)]TJ /F8 1 Tf 0 -1.2266 TD (could)Tj /F4 1 Tf 2.4533 0 TD [(look)-223.4(after)-226.6(themselves)-231.3(if)-220.6(necessary.)-234.5(The)-222.1(stress)-231(here)-226.8(is)-225.5(thus)-224.6(not)]TJ -2.4533 -1.2203 TD [(on)-277.2(being)-282.2(left)-283(alone,)-281.2(but)-280.8(on)-277.2(the)-283.2(ability)-280.6(to)-281.3(care)-279.8(for)-282(oneself.)]TJ 1.1128 -1.2203 TD [(Occasionally,)-510.2(people)-511.8(report)-514.6(needing)-511.3(daily)-507.5(assistance)-515.9(with)-508.9(a)]TJ -1.1128 -1.2266 TD [(circumscribed)-337.4(activity,)-336.1(but)-331.3(they)-333.3(are)-334.8(otherwise)-331.7(independent)-338.7(in)-331.8(ac-)]TJ 0 -1.2203 TD [(tivities)-279(of)-279.8(daily)-286.2(living.)-277.6(Illustrative)-284.7(examples:)]TJ /F11 1 Tf 1.1128 -1.8336 TD ()Tj /F4 1 Tf .999 0 TD [(A)-262.1(60-year-old)-270.5(woman)-266.1(has)-267.7(a)-267.5(slight)-263.2(mobility)-268.6(problem)-268.4(with)-268.6(her)]TJ 0 -1.2203 TD [(left)-327.3(arm)-323.2(and)-329.7(is)-326.7(unable)-328.4(to)-325.5(put)-325(her)-326(hand)-329.3(behind)-326(her)-326(head.)-328.3(She)]TJ 0 -1.2266 TD [(wears)-363.6(her)-357.6(hair)-361.2(up,)-362.3(and)-361.4(now)-355.9(needs)-364(help)-358.6(each)-365.7(day)-361.3(to)-357.1(put)-363(her)]TJ 0 -1.2203 TD [(hair)-323.2(in)-331.8(place.)-327.9(She)-328.3(can)-332.2(use)-324.6(her)-332.3(right)-324.3(hand)-329.3(and)-329.7(arm)-329.6(normally.)]TJ T* [(She)-315.7(has)-312(returned)-313.7(to)-319.2(work)-313.8(and)-310.8(to)-319.2(her)-313.4(usual)-315(social)-314.6(and)-317.1(leisure)]TJ T* (activities.)Tj /F11 1 Tf -.999 -1.2266 TD ()Tj /F4 1 Tf .999 0 TD [(A)-439.1(73-year-old)-441.3(man)-440.8(gets)-442(help)-440.8(to)-439.3(wash)-447.6(his)-440(hair)-437(because)-443.7(he)]TJ 0 -1.2203 TD [(feels)-402.2(dizzy)-398.4(when)-402.1(raising)-396.5(and)-399.3(lowering)-404.5(his)-395.8(head,)-404.1(but)-394.6(other-)]TJ T* [(wise)-331.4(is)-333(physically)-335.7(t)-336.7(and)-336.1(can)-332.2(ride)-335.9(a)-330.7(bicycle.)]TJ /F11 1 Tf -.999 -1.2266 TD ()Tj /F4 1 Tf .999 0 TD [(A)-382.2(70-year-old)-384.3(man)-383.9(gets)-385(daily)-387.4(help)-383.9(with)-382.4(taking)-386.9(medication,)]TJ 0 -1.2203 TD [(but)-261.8(otherwise)-274.8(is)-263.5(independent)-269.2(outside)-267.5(the)-270.5(home)-263.2(and)-266.5(is)-269.8(back)-268.4(to)]TJ T* [(his)-332.5(social)-333.6(and)-336.1(leisure)-335.7(activities.)]TJ -.999 -1.8336 TD [(In)-387.3(such)-393.7(cases,)-395.8(the)-397(assessor)-394(should)-394.3(not)-394.6(rate)-395.2(the)-390.7(person)-395.3(as)-394.6(SD,)]TJ -1.1128 -1.2266 TD [(given)-288.5(that)-293(the)-289.5(isolated)-292.4(limitation)-290.8(is)-295.1(not)-287.1(consistent)-292.6(with)-293.9(the)-289.5(overall)]TJ 0 -1.2203 TD [(picture)-277.6(of)-286.2(independence.)]TJ /F5 1 Tf 1.1128 -1.2203 TD [(Q2b.)-224.9(Do)-236.3(they)-229.3(need)-234(frequent)-231.9(help)-235.6(or)-229.1(someone)-230.9(to)-235.6(be)-227.6(around)-235.5(at)]TJ -1.1128 -1.2203 TD [(home)-279.4(most)-282.2(of)-279.8(the)-280.3(time?)]TJ /F4 1 Tf 1.1128 -1.2266 TD [(The)-335.9(patient)-342.3(is)-333(considered)-345.3(to)-331.8(be)-342.9(in)-338.2(the)-333.8(lower)-338.7(category)-345.1(of)-336.7(SD)-336(if)]TJ -1.1128 -1.2203 TD [(they)-257.4(cannot)-265.2(be)-260.7(left)-257.7(for)-263(8)-163.9(h)0(.)-261.7(This)-262.3(limit)-257.4(implies)-262.4(that)-261.4(a)-261.2(relative)-264.6(who)-261.1(is)]TJ T* [(caring)-280.4(for)-282(them)-279.9(cannot)-284.1(work)-275.8(full)-280.6(time)-283.9(away)-284.4(from)-278.7(home.)]TJ /F5 1 Tf 1.1128 -1.2266 TD [(Q2c.)-279.3(Was)-277.4(assistance)-286.9(at)-279.8(home)-279.4(essential)-283.9(before)-283.7(the)-280.3(injury?)]TJ /F4 1 Tf 0 -1.2203 TD .0117 Tc [(Record)-183.8(wheth)11.7(e)-8.7(r)-180.1(t)1.8(he)-179.9(person)-177.5(was)-178.7(d)-.5(ep)]TJ 14.2329 0 TD [(endent)-181.6(fo)11.6(r)-186(activities)-178.8(of)-180.2(daily)]TJ -15.3457 -1.2203 TD 0 Tc [(l)-9.9(i)-9.9(f)-14.8(e)-330.7(i)-9.9(n)-328.3(t)-16.2(he)-342.9(ho)-18(m)-9.4(e)-337(be)-20.4(f)-8.4(o)-12.2(r)-14.8(e)-330.7(i)-9.9(n)-12.2(j)-9.9(u)-12.2(r)-8.4(y)-12.2(.)-331.7(I)-8.4(f)-330.9(t)-16.2(he)-342.9(pe)-20.4(r)-8.4(s)-13.3(o)-12.2(n)-328.3(w)-15.5(a)-8.3(s)-335.8(d)0(i)-22(s)-7(a)-14.6(b)-12.2(l)-9.9(e)-8.3(d)-334.6(t)-9.9(o)-328.3(t)-16.2(he)]TJ 0 -1.2266 TD .0135 Tc [(s)6.5(a)-1.1(m)4.1(e)-323.5(exten)13.5(t)-331(bef)5.1(o)1.3(r)5.1(e)-323.5(in)13.5(j)-8.5(u)13.5(r)-7.1(y)-321.1(as)-322.3(they)-321.1(a)5.2(r)-1.3(e)-323.5(now)4.4(,)-324.5(r)5.1(ec)5.2(ord)-321.1()55.6()5.1(y)1.3(e)5.2(s).2(.)4.3()55.6()-323.7(I)5.1(f)-323.7(t)-2.7(h)13.5(e)]TJ 0 -1.2203 TD .0118 Tc [(pers)4.8(on)-455.6(was)-450.5(d)-.4(ep)11.8(e)-8.6(ndent)-453.3(to)-455.6(so)11.8(m)-9.7(e)-451.7(ex)11.8(t)-10.2(e)3.5(nt)-453.3(before)-458(injury,)-452.7(but)-453.3(their)]TJ T* .0115 Tc [(depen)11.5(d)-6.5(ency)-297.8(has)-299(i)1.6(ncreased,)-301.2(r)3.1(ecord)-297.8()60(no)60()-300.4(t)1.6(o)-297.8(s)-1.8(ignify)-297.8(that)-301.9(there)-300.3(h)-.7(as)]TJ 0 -1.2267 TD .0126 Tc [(been)-277.8(a)-280.2(c)4.4(hang)12.6(e)-7.8(.)]TJ /F1 1 Tf 1.1128 -2.6999 TD 0 Tc [(Follow-up)-471.1(questions.)]TJ /F4 1 Tf 10.319 0 TD [(If)-415.2(it)-418.1(is)-415.2(necessary)-421.2(to)-414(establish)-419.5(a)-419.2(time)]TJ -11.4318 -1.2203 TD [(limit,)-310.9(it)-316.9(can)-313.2(be)-317.6(helpful)-313.1(to)-312.9(ask)-318.3(what)-311.3(the)-314.8(maximum)-317.1(amount)-316.9(of)-311.4(time)]TJ T* [(would)-276.8(be)-286(that)-280.4(they)-276.4(could)-282.2(look)-280.3(after)-283.5(themselves.)]TJ ET 310.847 141.279 239.074 .51024 re f 310.847 57.26 239.074 .51025 re f 310.847 57.26 .51022 84.529 re f 549.468 57.26 .45355 84.529 re f BT /F5 1 Tf 8.9663 0 0 8.9663 326.7779 128.5795 Tm [(Specic)-281.8(issues)]TJ /F4 1 Tf T* [(The)-449.7(central)-450.8(focus)-452.7(is)-453.2(on)-447.9(the)-447.6(persons)-455(ability)-451.4(to)-445.6(look)-451(after)]TJ -1.1128 -1.2203 TD [(themself,)-373.3(rather)-365.2(than)-364.9(being)-370.7(left)-365.2(alone.)-369.7(The)-367.5(patient)-367.6(may)-364.9(never)]TJ 0 -1.2266 TD [(actually)-337.9(be)-336.6(on)-334.1(their)-339.4(own,)-333.5(but)-331.4(is)-339.3(nonetheless)-334.8(able)-335.7(to)-338.2(look)-330.9(after)]TJ 0 -1.2203 TD [(themself.)-487.1(The)-481.3(notes)-479.4(about)-484.5(companionship)-485.5(and)-481.5(safety)-483.9(issues)]TJ T* [(also)-283.9(apply)-275.9(when)-282(considering)-276.9(whether)-283.2(the)-276.9(person)-281.5(can)-281.6(look)-273.9(after)]TJ 0 -1.2266 TD [(themself)-281.9(for)-282(8)-170.2(h)0(.)]TJ ET 59.754 631.332 239.131 .51019 re f 59.754 546.52 239.131 .51025 re f 59.754 546.52 .51024 85.323 re f 298.375 546.52 .51022 85.323 re f BT /F5 1 Tf 8.9663 0 0 8.9663 75.7417 618.6329 Tm [(Specic)-281.8(issues)]TJ /F4 1 Tf 0 -1.2203 TD [(Patients)-183.5(who)-178.9(do)-182.4(not)-185.9(obey)-177.5(commands,)-189.1(and)-178(this)-184.3(is)-181.3(considered)-187.2(to)]TJ -1.1128 -1.2203 TD [(be)-393.5(attributable)-397.2(to)-388.7(language)-393.1(problems)-395.6(or)-393.6(severe)-393.8(cognitive)-398.2(im-)]TJ 0 -1.2266 TD [(pairment)-217.4(\(e.g.,)-214.6(dementia\),)-216(are)-214.6(conscious)-221.8(and)]TJ /F8 1 Tf 17.7864 0 TD [(should)-210.9(not)]TJ /F4 1 Tf 4.3755 0 TD [(be)-216.4(rated)]TJ -22.1618 -1.2203 TD [(as)-495.8(VS.)-490.7(Purposive)-497.6(behavior)-494.4(\(reaching)-499(for)-490.6(food)-500.2(or)-488.5(grooming)]TJ T* [(utensils,)-496.4(taking)-494.4(off)-490.6(articles)-499.7(of)-494.8(clothing,)-494(etc.\))-499.3(indicates)-496.6(con-)]TJ 0 -1.2266 TD [(sciousness)-280.6(in)-281.3(the)-283.2(absence)-279.3(of)-279.8(language.)]TJ ET 59.754 383.017 239.131 .51025 re f 59.754 338.74 239.131 .51025 re f 59.754 338.74 .51024 44.787 re f 298.375 338.74 .51022 44.787 re f BT /F5 1 Tf 8.9663 0 0 8.9663 75.7417 370.318 Tm (Skipping)Tj /F4 1 Tf 0 -1.2203 TD [(If)-174.9(th)22.2(e)-191.6(p)0(e)17.5(r)0(s)22.5(o)13.1(n)-189.2(d)0(o)19.9(e)0(s)-179.7(n)0(o)19.9(t)-193.2(n)13.1(e)0(e)21.4(d)-189.2(as)22.7(si)21.1(st)21.1(an)17.5(ce)21.4(,)-192.6(a)0(s)22.7(s)0(u)25.1(m)0(e)-182(t)0(h)22.2(a)0(t)-182.5(t)0(h)22.3(e)0(y)-178.5(d)13.1(id)-180.1(no)19.9(t)]TJ -1.1128 -1.2203 TD -.0146 Tc [(ne)-14.6(e)6.8(d)-286(he)-14.6(l)5.2(p)-286(be)-14.6(f)6.6(o)-1.5(r)-14.6(e)-277.9(\(Q)-14.6(2c)]TJ /F7 1 Tf 8.9912 0 TD 0 Tc (=)Tj /F4 1 Tf .7082 0 TD -.0143 Tc [(no)-14.3(\),)-282.8(a)-14.3(n)9.6(d)-285.7(g)-1.2(o)-279.4(t)-14.3(o)-276.6(Q)-14.3(u)8.7(e)-14.3(s)8.4(t)-14.3(i)3.9(o)-1.2(n)-285.7(3)-1.2(a)-281.8(\()-14.3(S)4.5(hop)-14.3(p)5.6(i)-14.3(n)8(g)-1.2(\))-14.3(.)]TJ ET 310.847 731.735 239.074 .51025 re f 310.847 653.669 239.074 .51019 re f 310.847 653.669 .51022 78.576 re f 549.468 653.669 .45355 78.576 re f BT /F5 1 Tf 8.9663 0 0 8.9663 326.7779 719.036 Tm 0 Tc [(Specic)-281.8(issues)]TJ /F4 1 Tf 0 -1.2203 TD [(A)-236.8(difculty)-238.9(may)-238.4(arise)-237.8(if)-239.6(an)-235.4(activity)-244.6(was)-239.4(not)-236.5(normally)-234(carried)]TJ -1.1128 -1.2266 TD [(out)-344(before)-348.5(the)-346.4(injury.)-345.7(For)-347.5(example,)-349.4(someone)-347.6(may)-345.9(not)-344(usually)]TJ 0 -1.2203 TD [(prepare)-217.7(main)-216.7(meals)-219.8(for)-212.4(themself.)-221.5(In)-216.6(this)-215.9(case,)-218.1(it)-215.7(is)-212.9(sufcient)-219.5(that)]TJ T* [(the)-188.3(person)-180.3(could,)-190.3(if)-182.7(the)-182(necessity)-190.3(arose,)-186.1(prepare)-186.1(food,)-186.9(even)-186.2(if)-182.7(this)]TJ 0 -1.2266 TD [(would)-283.1(only)-280.3(be)-279.7(a)-280.1(snack.)]TJ /F3 1 Tf -28.6681 9.535 TD [(MANUAL)-341(FOR)-334(THE)-335.2(GOSE)-330.7(INTERVIEW)]TJ 52.4612 0 TD (2439)Tj ET endstream endobj 72 0 obj <>stream /GS1 gs BT /F10 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(Independence)-331.8(outside)-333.8(the)-334.8(home)]TJ /F5 1 Tf 1.1128 -1.8336 TD [(Q3a.)-276.9(Are)-284.9(they)-279.9(able)-281.3(to)-279.8(shop)-280.9(without)-278.2(assistance?)]TJ /F4 1 Tf 0 -1.2203 TD [(This)-376.1(refers)-377.6(to)-376.1(being)-377(able)-380(to)-376.1(buy)-377.9(items)-379.5(as)-375.7(part)-380.1(of)-374.7(daily)-374.7(living.)]TJ -1.1128 -1.2266 TD [(Independence)-438.8(requires)-441.3(ability)-432.4(to)-439.3(plan,)-437.4(take)-436.9(care)-437.9(of)-437.9(money,)-436.4(and)]TJ 0 -1.2203 TD [(behave)-282.5(appropriately)-283.7(in)-281.3(public.)]TJ /F5 1 Tf 1.1128 -1.2203 TD [(Q3b.)-345(Were)-352.6(they)-349.4(able)-350.8(to)-349.4(shop)-350.5(without)-354(assistance)-350.2(before)-353.3(the)]TJ -1.1128 -1.2266 TD (injury?)Tj /F4 1 Tf 1.1128 -1.2203 TD [(Re)-12.5(co)-7.8(r)-8.4(d)-467.4(wh)-8.7(e)-8.2(t)0(h)-9.4(e)-8.2(r)-470(t)0(h)-9.4(e)-469.8(pe)-7.8(r)-8.4(s)-7(on)-473.2(wa)-11.1(s)-468.6(a)-8.2(bl)-9.4(e)-469.8(t)0(o)-477.3(s)-7(hop)-479.1(in)-9.4(de)-7.8(pe)-14.1(nd)-11.7(en)-7.8(tl)-13.4(y)]TJ -1.1128 -1.2203 TD [(be)-14.1(fo)-7.9(re)-288.6(i)-9.9(n)0(j)-9.4(u)0(r)-8(y)0(.)]TJ /F1 1 Tf 1.1128 -9.3516 TD [(Follow-up)-370(questions.)]TJ /F4 1 Tf 10.2178 0 TD [(If)-314.1(the)-314.8(person)-313.1(reports)-312.9(that)-318.3(they)-314.3(are)-315.8(un-)]TJ -11.3307 -1.2266 TD [(able)-291.4(to)-293.9(shop,)-286.7(then)-289(establish)-293.1(capability:)]TJ /F8 1 Tf 15.8199 0 TD [(If)-290.2(your)-292.5(life)-290.7(depended)-294.2(on)-289.9(it,)]TJ -15.8199 -1.2203 TD [(could)-212.7(you)-209.6(get)-213.6(out)-211.2(and)-207.2(buy)-215.9(even)-207.6(a)-214.5(single)-211.1(item?)-213.7(Can)-211.9(you)-209.6(go)-207.7(to)-211.7(a)-214.5(local)]TJ T* [(shop)-188.9(to)-186.4(buy)-190.6(milk)-188.8(or)-189.9(bread)]TJ /F4 1 Tf 10.0028 0 TD [(?)-185.3(I)0(f)-187.6(there)-192.4(is)-187.6(no)-188.7(local)-187.5(shop,)-191.8(you)-188.2(may)-187.8(need)-186.2(to)]TJ -10.0028 -1.2266 TD [(ask)-210.8(the)-207.3(hypothetical)-213.5(question:)]TJ /F8 1 Tf 12.0451 0 TD [(If)-208(there)-209.9(were)-211.1(a)-208.2(local)-210.4(shop,)-210.8(would)-208.6(you)]TJ -12.0451 -1.2203 TD [(be)-279.6(able)-282.7(to)-281.3(buy)-279.2(something)]TJ /F4 1 Tf 10.142 0 TD (?)Tj /F5 1 Tf -9.0291 -11.906 TD [(Q4a.)-276.9(Are)-284.9(they)-279.9(able)-281.3(to)-279.8(travel)-280.4(locally)-282.9(without)-284.5(assistance?)]TJ /F4 1 Tf 0 -1.2266 TD [(This)-237(question)-235.4(refers)-238.5(to)-237(whether)-239(or)-241.9(not)-236.5(the)-232.6(patient)-241.1(can)-237.3(get)-238.9(around)]TJ -1.1128 -1.2203 TD [(locally)-184.2(by)-182.4(themselves,)-183.6(by)-182.4(one)-178(means)-184.2(of)-185(transport)-183.2(or)-178.7(another,)-181.7(and)-184.3(not)]TJ T* [(just)-279.2(by)-283.6(walking.)]TJ /F5 1 Tf 1.1128 -1.2266 TD [(Q4b.)-288.1(Were)-295.7(they)-292.5(able)-293.9(to)-292.5(travel)-293.1(without)-290.8(assistance)-293.3(before)-296.4(the)]TJ -1.1128 -1.2203 TD (injury?)Tj /F4 1 Tf 1.1128 -1.2203 TD 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[(a\))-497.2(Reduced)-337.3(work)-332.7(capacity.)]TJ 0 -1.2203 TD [(b\))-494.8(Able)-703.3(to)-704.9(work)-699.5(only)-703.9(in)-704.9(a)-697.5(sheltered)-710.2(workshop)-698.7(or)-703.5(non-)]TJ .999 -1.2203 TD [(competitive)-337.7(job,)-327.9(or)-336.7(currently)-336.2(unable)-334.7(to)-331.8(work.)]TJ -.8915 -1.2266 TD [(If)-193.9(the)-194.7(person)-193(is)-187.6(not)-192.2(able)-196.6(to)-192.7(work)-187.3(to)-192.7(their)-194(previous)-196(capacity,)-193.8(record)]TJ -1.1128 -1.2203 TD [(the)-308.5(level)-307.6(of)-305.1(restriction.)-309.4(Any)-305.3(of)-305.1(the)-308.5(following)-310.8(indicate)-306.3(reduced)-309.9(ca-)]TJ T* [(pacity)-395.6(for)-395.8(work:)-393.2(1\))-393.6(change)-396.3(in)-395.1(level)-396.1(of)-393.7(skill)-390.2(or)-393.6(responsibility)-400(re-)]TJ 0 -1.2266 TD [(quired;)-332.1(2\))-330.4(change)-333.1(from)-335.6(full-time)-332.7(to)-325.5(part-time)-337.4(working;)-332.5(3\))-330.4(special)]TJ 0 -1.2203 TD 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[(week\))-311.8(would)-308.4(not)-306.1(be)-304.9(counted,)-311.9(while)-308.5(more)-310.1(than)-308(this)-304.5(would)]TJ T* [(be)-260.7(considered)-256.8(a)-261.2(restriction.)-258.8(The)-260(focus)-256.7(is)-263.5(on)-258.3(function)-255.8(at)-258.4(the)]TJ T* [(current)-421.6(time)-423(point.)-419.5(Future)-422(plans,)-425.4(such)-419(as)-419.9(going)-425.2(back)-420.2(to)]TJ 0 -1.2266 TD [(work)-332.7(next)-333.3(week,)-337.9(are)-334.8(not)-331.3(included.)]TJ /F11 1 Tf -.999 -1.2203 TD ()Tj /F4 1 Tf .999 0 TD [(Usually)-277.1(if)-271.2(a)-273.8(person)-268.8(is)-276.1(on)-270.9(sick)-271.2(leave)-274.4(as)-274.5(judged)-275.4(by)-270.9(a)-273.8(doctor,)]TJ 0 -1.2203 TD [(they)-396.5(are)-404.3(recorded)-394.3(as)-401(unable)-397.9(to)-401.4(work,)-392.6(even)-401.2(if)-397.7(they)-396.5(think)]TJ 0 -1.2266 TD [(they)-270(could)-263.2(work.)-272.4(However,)-266.5(sometimes)-270.8(there)-268.3(is)-269.8(a)-267.5(policy)-266.8(of)]TJ 0 -1.2203 TD [(putting)-293.2(people)-296.8(on)-289.9(leave)-299.7(irrespective)-300.5(of)-292.5(their)-295.2(actual)-296.9(ability)]TJ T* [(to)-319.2(work)-313.8(\(e.g.,)-315.8(in)-319.2(some)-315(systems)-313.6(people)-322.1(may)-314.3(automatically)]TJ 0 -1.2266 TD [(be)-368.2(put)-363(on)-359.4(leave)-369.2(for)-364.1(several)-365.7(months)-366.2(after)-365.7(a)-362.3(neurosurgical)]TJ 0 -1.2203 TD [(operation\).)-269(In)-267.2(such)-267.2(cases,)-263(a)-267.5(judgment)-269.3(must)-266(be)-267(made)-265.7(about)]TJ T* [(whether)-270.6(the)-264.2(person)-268.8(is)-269.8(capable)-269.5(of)-267.2(working.)-268.7(For)-265.3(example,)-267.2(if)]TJ 0 -1.2266 TD [(the)-390.7(person)-389(reports)-395.1(that)-387.9(they)-390.2(are)-391.7(capable)-389.6(of)-393.6(working)-385.9(and)]TJ 0 -1.2203 TD [(has)-255.1(few)-247.1(or)-254.5(no)-245.6(symptoms,)-252.7(then)-251.1(it)-253.7(is)-250.8(reasonable)-252.9(to)-249.6(rate)-256.1(them)]TJ T* [(as)-337.7(able)-329.4(to)-338.2(work.)]TJ /F11 1 Tf -.999 -1.2203 TD ()Tj /F4 1 Tf .999 0 TD [(A)-363.2(patient)-367.6(may)-364.9(be)-361.8(prevented)-369.9(from)-360.9(doing)-368.3(certain)-368.6(kinds)-363.2(of)]TJ 0 -1.2266 TD [(work)-237.9(activity)-238.3(\(e.g.,)-239.9(driving\))-237(because)-241.4(there)-236.6(is)-238.2(a)-235.9(risk)-239.8(of)-235.6(post-)]TJ 0 -1.2203 TD [(traumatic)-394.1(epilepsy,)-392.5(although)-392.3(the)-390.7(person)-389(has)-394.2(not)-388.3(actually)]TJ T* [(had)-462.5(a)-463.5(seizure.)-469.8(In)-463.2(these)-462.9(cases,)-471.7(the)-460.2(restriction)-470.9(should)-463.9(be)]TJ 0 -1.2266 TD [(ignored)-366(as)-363(far)-360.2(as)-363(possible)-363(for)-364.1(the)-359.1(purposes)-363.9(of)-362(rating.)-367.1(On)]TJ 0 -1.2203 TD [(the)-359.1(other)-354.4(hand,)-357.5(if)-359.7(the)-359.1(patient)-354.9(has)-362.5(actually)-356.8(suffered)-357.7(a)-356(sei-)]TJ T* [(zure,)-507.9(then)-504(limitations)-500.1(imposed)-507.3(by)-504.9(the)-504.5(risk)-499(of)-507.5(epilepsy)]TJ 0 -1.2266 TD [(should)-331.1(be)-336.6(taken)-335.2(into)-334.9(account.)]TJ /F11 1 Tf -.999 -1.2203 TD ()Tj /F4 1 Tf .999 0 TD .0132 Tc [(Ju)-5.3(dg)-5.3(ing)-384.7(w)-2.3(he)-7.7(th)-5.3(er)-387.3(someo)-5.3(n)1(e)-387.1(i)-3(s)-385.8(capa)-7.7(b)1(le)-387.1(of)-387.3(work)-5.3(in)-5.3(g)-384.7(w)-2.3(hen)]TJ 0 -1.2203 TD .0145 Tc [(the)-6.4(y)-402.3(are)-404.7(n)2.3(ot)-400(ac)-6.4(tually)-402.3(working)-402.3(can)-408.6(be)-404.7(difcult)-406.3(bec)-6.4(a)-.1(us)-5.2(e)]TJ T* [(p)-4.1(r)-.4(oble)-6.5(m)5(s)-409.9(m)-1.3(ay)-402.4(o)-4.1(n)2.2(ly)-408.7(bec)-6.5(o)2.2(me)-404.8(ap)-4.1(par)-6.7(e)-.2(nt)-406.4(wh)-4.1(en)-402.4(th)-4.1(e)-404.8(p)2.2(e)-6.5(r)-.4(son)]TJ 0 -1.2266 TD -.0149 Tc [(a)-14.9(c)12.9(tually)-381.1(re)-14.9(t)11.3(u)4.6(r)-14.9(n)8.8(s)-376(t).5(o)-374.8(w)-14.9(o)14.4(r)-14.9(k)15.1(.)-378.2(I)-14.9(n)-364.3(this)-376(c)-14.9(a)12.9(s)-14.9(e)14.1(,)-378.2(a)-14.9(s)14.1(k)-1.8(ing)-374.8(a)-14.9(b)15.3(out)-378.8(symp-)]TJ 0 -1.2203 TD [(toms)-300.1(and)-298.9(p)-1.8(roblems)-300.1(t)-14.9(h)13.7(a)-14.9(t)-285.9(m)1(ight)-296.6(i)-14.9(n)13.7(te)-14.9(r)12.7(f)2(e)-14.9(r)12.7(e)-301.4(w)1.3(i)-14.9(t)9.7(h)-298.9(w)1.3(ork)-298.9(c)-14.9(a)12.9(n)-298.9(help)]TJ T* -.0154 Tc [(to)-444.9(inf)-15.4(o)14.6(r)-15.4(m)-431.5(the)-441(j)-15.4(u)13.2(dgment.)-442(Norma)-15.4(l)10.8(ly,)-442(a)1.6(bility)-438.5(t)-15.4(o)-429.4(work)-444.9(is)-439.7(in-)]TJ 0 -1.2266 TD -.0149 Tc [(dica)-14.9(t)11.3(i).5(ve)-345.6(of)-345.8(ind)4.6(e)-14.9(p)15.3(e)-14.9(n)9(d)4.6(e)-14.9(n)15.3(c)-14.9(e)12.9(;)-347.2(howeve)-14.9(r)12.7(,)-346.6(o)-1.8(cca)-14.9(s)7.8(i).5(o)4.6(n)-1.8(al)-14.9(l)9.7(y)4.6(,)-346.6(s)-14.9(o)10.2(m)1(eone)]TJ 0 -1.2203 TD -.0145 Tc [(in)-399.7(the)-395.8(U)1.7(pper)-396(S).1(D)-396.7(r)-14.5(a)13.1(nge)-395.8(ma)-14.5(y)-382.7(b)-1.4(e)-395.8(w)1.7(or)-14.5(k)15.5(i).9(ng)-399.7(in)-393.4(s)-14.5(h)10.6(elte)-14.5(r)13.1(e)-14.5(d)-382.7(e)-14.5(m)12.1(-)]TJ T* [(ploy)5.1(me)-14.4(n)9.5(t)1(.)]TJ /F11 1 Tf -.999 -1.2266 TD 0 Tc ()Tj /F4 1 Tf .999 0 TD [(In)-267.2(case)12.5(s)-272.6(whe)14.7(re)-269.6(the)-264.2(pers)14.7(on)-264.6(perf)19.6(orm)14.3(ed)-273.3(mor)14.3(e)-273.8(tha)14(n)-271.4(one)-266.5(majo)17.3(r)]TJ 0 -1.2203 TD [(rol)13.8(e)-242.2(bef)15.4(ore)-237.5(inj)18.7(ury)-235.1(\(e.)12(g.,)-226.7(wor)14.5(king)-229.7(and)-234.9(car)13(egi)14(vin)16.4(g\),)-232.2(the)14(se)-236.6(can)]TJ T* [(be)-323.9(tre)11.4(at)13.5(ed)-323.9(toge)14.5(the)14(r)-324.6(when)-319.9(con)18(sid)15.2(eri)11.4(ng)-321.5(cha)15.6(nge)-323.4(in)-319.2(sta)12.8(tus)15.2(.)]TJ ET 310.847 445.946 239.074 .51025 re f 310.847 358.583 239.074 .51022 re f 310.847 358.583 .51022 87.874 re f 549.468 358.583 .45355 87.874 re f BT /F5 1 Tf 8.9663 0 0 8.9663 326.7779 433.2471 Tm (Skipping)Tj /F4 1 Tf T* [(If)-314.1(they)-320.6(are)-315.8(able)-316.7(to)-319.2(resume)-319.1(social)-321(and)-317.1(leisure)-316.7(activities,)-317.4(then)]TJ -1.1128 -1.2203 TD [(assume)-311.3(that)-305.7(they)-301.7(participated)-313.4(before)-304.3(injury)-304.9(\(6c)]TJ /F7 1 Tf 19.1711 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(yes\),)-304.3(skip)-306.8(6b,)]TJ -19.8919 -1.2266 TD [(and)-279.2(go)-283.6(to)-281.3(7a.)]TJ 1.1128 -1.2203 TD [(If)-282.4(it)-285.3(is)-282.4(not)-280.8(possible)-287.1(to)-281.3(establish)-286.8(any)-285.5(regular)-282.5(pre-injury)-285.3(social)]TJ -1.1128 -1.2203 TD [(and)-203.3(leisure)-209.3(activities,)-203.6(skip)-205.6(Questions)-207.8(6a)-203.8(and)-203.3(6b)-201.4(and)-203.3(check)-207.1()54.8(No)56.7()]TJ 0 -1.2266 TD [(for)-282(Question)-282.9(6c.)]TJ /F3 1 Tf -28.6681 42.6291 TD [(MANUAL)-341(FOR)-334(THE)-335.2(GOSE)-330.7(INTERVIEW)]TJ 52.4612 0 TD (2441)Tj ET endstream endobj 80 0 obj <>stream /GS1 gs BT /F5 1 Tf 8.9663 0 0 8.9663 72 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(Q6c.)-285.6(Did)-295.3(they)-286.2(engage)-291.3(in)-292.5(regular)-291(social)-286.9(and)-292.9(leisure)-289.9(activities)]TJ -1.1128 -1.2203 TD [(outside)-282.2(home)-279.4(before)-283.7(the)-280.3(injury?)]TJ /F4 1 Tf 1.1128 -1.2266 TD [(Almost)-341.9(everyone)-341.1(will)-342.2(have)-338(some)-340.3(regular)-339.4(pre-injury)-342.2(social)-346.2(and)]TJ -1.1128 -1.2203 TD [(leisure)-285.1(activities,)-279.5(but)-280.8(it)-278.9(may)-282.7(take)-285.1(prompting)-275.3(to)-281.3(elicit)-283.6(these.)]TJ /F10 1 Tf 0 -62.9383 TD [(Family)-334(and)-335.7(friendships)]TJ /F5 1 Tf 1.1128 -1.8336 TD [(Q7a.)-397(Have)-402.3(there)-398(been)-398.4(psychological)-400.9(problems)-403.8(which)-396.5(have)]TJ -1.1128 -1.2203 TD [(resulted)-337.1(in)-336.7(ongoing)-332.9(family)-332.3(disruption)-338.8(or)-330.2(disruption)-338.8(to)-330.4(friend-)]TJ T* (ships?)Tj /F4 1 Tf 1.1128 -1.2266 TD [(The)-373.8(question)-374.5(is)-377.3(directed)-380.7(at)-372.2(assessing)-375.9(alterations)-382.2(in)-376.1(close)-374.3(rela-)]TJ -1.1128 -1.2203 TD [(tionships)-218.7(as)-223.9(a)-216.9(result)-220(of)-222.9(injury.)-219.3(Changes)-222.3(may)-219.5(be)-216.4(increased)-228.1(friction)-218.1(in)]TJ T* [(relationships,)-231.1(but)-223.9(also)-227(can)-231(take)-228.2(the)-226.3(form)-228.1(of)-229.2(withdrawal)-229.9(or)-222.9(isolation.)]TJ /F1 1 Tf 29.1107 67.0039 TD [(Follow-up)-585(questions.)]TJ /F4 1 Tf 10.4391 0 TD .0132 Tc [(A)-527.1(l)3.3(is)6.2(t)-527.8(o)1(f)-532.7(t)3.3(ypical)-527.8(pos)6.2(t)13.2(b)-4.8(r)-1.6(ain)-523.8(i)-3(n)13.2(j)-8.8(u)13.2(r)-7.4(y)]TJ -11.552 -1.2203 TD .0114 Tc [(changes)-261.2(i)1.6(s)-261.2(g)-.8(iven)-266.3(in)-260(order)-256.3(t)-4.8(o)-260(h)-.8(elp)-260(e)-3.2(licit)-264(p)-.8(roblems)-261.2(i)1.5(n)-260(r)-3.4(elatio)11.4(n)-6.6(s)-1.9(hips,)]TJ 0 -1.2266 TD .012 Tc [(an)-202.5(area)-204.9(in)-208.8(which)-202.5(t)2.1(he)-204.9(person)-202.5(may)-202.5(b)-.2(e)-204.9(r)-2.8(eluctant)-200.2(to)-208.8(admit)-206.5(p)12(r)-8.6(o)-.2(b)12(l)-10(ems)5(.)-205.9(It)]TJ 0 -1.2203 TD [(can)-486.9(be)-483(useful)-484.6(to)-493.2(g)12.1(o)-492.8(th)12.1(r)-8.5(oug)12.1(h)-492.8(t)-4.1(he)-483(pro)12.1(b)-5.9(lems)-488.1(listed,)-490.3(p)-.1(articu)12.1(l)-9.9(arly)]TJ T* .0109 Tc [(change)-300.9(in)-298.4(m)-4.8(o)-1.3(o)10.9(d)-7.1(,)-301.8(b)-1.3(ecause)-300.9(these)-300.9(a)-3.7(re)-300.9(li)-5.3(kely)-304.8(to)-298.4(affect)-296.1(rel)-5.3(a)2.7(ti)-5.3(o)10.9(n)-7.1(ships.)]TJ 0 -1.2266 TD .0115 Tc [(This)-204.2(questio)11.5(n)-208.8(i)1.6(s)-204.2(not)-200.7(intended)-203(t)1.6(o)-203().8(nd)-203(ou)11.5(t)-212.8(w)2.4(heth)11.5(e)-8.9(r)-205.6(they)-203(are)-205.4(i)1.6(rritable,)]TJ 0 -1.2203 TD .0136 Tc [(etc.)4.4(thes)6.6(e)-184.3(a)5.3(r)-1.2(e)-178(e)-1(xa)5.3(m)4.2(p)1.4(les)-183.1(o)13.6(f)-190.4(c)5.4(han)13.6(g)-4.4(es)-176.8(th)13.6(a)-6.8(t)-179.6(ca)5.3(n)-181.9(i)3.7(m)4.2(p)1.4(ac)5.4(t)-179.6(r)-1.2(e)5.3(l)-2.6(a)5.4(t)3.7(io)13.6(nships)6.6(.)]TJ T* [(Re)5.4(latio)13.6(n)-4.4(ship)-466.5(pr)5.2(oblem)4.2(s)-467.6(m)4.2(ay)-466.4(ar)5.2(is)6.6(e)-468.9(f)-1.2(r)5.2(o)1.4(m)-470(o)13.6(t)-8.4(h)13.6(e)-6.8(r)-469.1(so)13.6(urc)5.4(e)-1(s,)-463.5(suc)5.4(h)-466.5(as)]TJ 0 -1.2266 TD .0113 Tc [(cognitive)-281.5(i)-4.9(mpairment)-283.1(o)11.3(r)-293.8(i)1.4(njury-rel)-4.9(a)3(ted)-285.4(p)11.3(h)-6.7(y)-.9(sical)-283.1(i)1.4(m)-4.4(p)11.3(a)-9.1(i)1.4(rment)-4.9(,)-282.5(and)]TJ 0 -1.2203 TD .0122 Tc [(these)-413.4(a)3.9(re)-407(also)-410.9(counted)-410.9(a)3.9(s)-412.1(s)-1.1(ou)12.2(r)-8.4(c)-2.4(es)-412.1(of)-407.2(disru)12.2(p)-5.8(tion)12.2(.)-420.2(T).2(he)-407(aim)-414.5(i)2.3(s)-412.1(t)2.3(o)]TJ T* .0118 Tc [(estab)11.8(l)-10.2(ish)-303.9(w)2.7(hether)-312.8(their)-312.8(r)3.4(elation)11.8(s)-7.4(hips)-305(are)-312.6(s)4.8(trained,)-307.3(an)11.8(d)-316(i)1.9(f)-306.5(s)-1.5(o,)-307.3(ho)11.8(w)]TJ 0 -1.2266 TD .014 Tc [(muc)5.7(h)1.8(.)]TJ /F5 1 Tf 1.1128 -1.2203 TD 0 Tc [(Q7b.)-281.8(What)-277(has)-282.8(been)-284.6(the)-280.3(extent)-277.6(of)-279.8(disruption)-281.9(or)-286(strain?)]TJ /F4 1 Tf T* [(The)-209.4(following)-203.3(denitions)-205.4(apply:)-203.5(1\))-210.3(Occasionalsome)-204.9(problems)]TJ -1.1128 -1.2203 TD [(post-injury,)-287.9(but)-287.1(less)-291.4(than)-289(once)-287.4(a)-286.5(week)-290.7(and)-285.5(not)-287.1(causing)-291.2(continuous)]TJ 0 -1.2266 TD [(strain.)-298.8(For)-290.6(example,)-292.5(occasional)-298.6(bad)-291.8(temper,)-293.2(but)-293.4(things)-290.8(blow)-296.2(over;)]TJ 0 -1.2203 TD [(2\))-248.2(Frequentproblems)-242.7(at)-245.7(least)-245.6(weekly,)-246.1(strain)-245.3(on)-239.3(relationships,)-243.8(but)]TJ T* [(regarded)-217.2(as)-217.6(tolerable.)-216.5(For)-214.7(example,)-216.6(temper)-214.4(outbursts)-217.3(at)-214.1(least)-220.3(once)-211.5(a)]TJ 0 -1.2266 TD [(week)-233.8(resulting)-228.9(in)-230.7(modication)-228.6(of)-229.2(closeness)-231.7(of)-229.3(relationships;)-231.7(and)-228.6(3\))]TJ 0 -1.2203 TD [(Constant)-271.7(daily)-273.6(problemsbreakdown)-274.5(or)-267.2(threatened)-274.7(breakdown)-271.9(of)]TJ T* [(relationship)-303.4(within)-297(family)-298.2(or)-298.8(friendship;)-300(problems)-300.7(regarded)-299.4(as)-299.8(in-)]TJ 0 -1.2266 TD [(tolerable.)-355.6(If)-358.3(the)-352.7(patient)-354.9(has)-349.9(become)-355.6(very)-350.8(withdrawn)-356.7(and)-355(socially)]TJ 0 -1.2203 TD [(isolated)-444.1(as)-432.6(a)-438.2(result)-435(of)-437.9(injury,)-434.3(then)-440.8(this)-437.2(also)-435.6(represents)-437.6(constant)]TJ T* (disruption.)Tj /F5 1 Tf 1.1128 -1.2203 TD [(Q7c.)-431(Were)-434.8(there)-429.6(similar)-431.7(problems)-429.1(with)-430.2(family)-433.5(or)-431.4(friends)]TJ -1.1128 -1.2266 TD [(before)-283.7(the)-280.3(injury?)]TJ /F4 1 Tf 1.1128 -1.2203 TD [(The)-354.8(question)-349.2(concerns)-348.6(whether)-352.8(similar)-353.5(problems)-351.3(were)-350.2(present)]TJ -1.1128 -1.2203 TD [(before)-190.5(injury.)-181.4(Conrm)-183.6(that)-179.2(any)-184.3(problems)-186.9(with)-180.1(relationships)-183.9(are)-183(new)]TJ 0 -1.2266 TD [(since)-260.5(the)-264.2(injury,)-257.2(or)-254.5(at)-258.4(least)-264.5(have)-255.8(become)-260.8(markedly)-264(worse)-260(since)-260.5(the)]TJ 0 -1.2203 TD [(injury.)-231.9(If)-231.9(the)-232.6(person)-230.9(says)-236.8(that)-229.8(similar)-233.4(problems)-231.2(were)-230.1(present)-236.9(before)]TJ T* [(injury,)-181.4(then)-181.5(a)-185.3(follow-up)-182.9(question)-178.5(must)-183.8(be)-178.5(asked)-187(to)-180.1(establish)-179.3(whether)]TJ 0 -1.2266 TD [(things)-196(are)-189.3(signicantly)-198.2(worse.)-193.4(If)-187.6(they)-194.2(are)-189.3(worse,)-193.4(Question)-194.4(7c)-191.1(should)]TJ 0 -1.2203 TD [(be)-286(marked)-279.9()54.8(No.)53.8()]TJ /F10 1 Tf 0 -21.1691 TD [(Return)-337.9(to)-330.4(normal)-336.4(life)]TJ /F5 1 Tf 1.1128 -1.8336 TD [(Q8a.)-346.4(Are)-348.1(there)-347.4(any)-344.9(other)-351.3(current)-347.5(problems)-346.9(relating)-351.6(to)-343.1(the)]TJ -1.1128 -1.2266 TD [(injury)-281.5(which)-282.7(affect)-281.6(daily)-282.4(life?)]TJ /F4 1 Tf 1.1128 -1.2203 TD [(The)-304.3(question)-304.9(concerns)-304.3(symptoms)-300.4(that)-305.7(have)-300.1(arisen)-306.9(since)-304.8(the)-302.1(in-)]TJ -1.1128 -1.2203 TD [(jury)-346.1(that)-343.6(are)-347.4(signicant)-346.9(enough)-340.9(to)-344.5(impinge)-345.7(on)-340.5(functioning)-346.8(in)-338.2(ev-)]TJ T* [(eryday)-282.7(life.)]TJ ET 313.058 285.222 239.131 .51025 re f 313.058 143.093 239.131 .51024 re f 313.058 143.093 .51025 142.639 re f 551.679 143.093 .51019 142.639 re f BT /F5 1 Tf 8.9663 0 0 8.9663 329.0456 272.5228 Tm [(Specic)-281.8(issues)]TJ /F4 1 Tf T* [(The)-392.8(presence)-401.6(of)-393.6(a)-394(reported)-395.9(change)-396.3(in)-395.1(personality)-394.7(or)-393.6(other)]TJ -1.1128 -1.2203 TD [(post-TBI)-314.5(impairment)-318.9(is)-314.1(not)-312.4(of)-317.8(itself)-312.5(sufcient)-320.7(to)-312.9(warrant)-317.5(clas-)]TJ 0 -1.2266 TD [(sifying)-248.7(the)-251.6(person)-249.9(as)-249.2(moderately)-250.5(disabledthe)-254.4(change)-250.9(must)-253.4(be)]TJ 0 -1.2203 TD [(having)-281.7(an)-279.6(adverse)-279.5(impact)-285.4(on)-277.2(family)-285.5(and)-279.2(friendships.)]TJ 1.1128 -1.2203 TD [(This)-420.4(question)-418.7(should)-419.6(consider/elicit)-422.3(whether)-422.3(a)-419.2(patient)-424.5(has)]TJ -1.1128 -1.2266 TD [(become)-425.2(isolated)-431.5(and/or)-429.7(withdrawn)-426.3(since)-431.2(their)-427.9(injury.)-421.6(In)-431.6(this)]TJ 0 -1.2203 TD [(case,)-376.1(it)-380.1(is)-371(more)-379.7(relevant)-374.4(to)-376.1(consider)-381.8(how)-374.9(tolerable)-377.9(this)-374(is)-377.3(for)]TJ T* [(others)-279.2(rather)-283(than)-282.7(the)-283.2(frequency)-279.9(of)-279.8(the)-283.2(problem.)]TJ 1.1128 -1.2266 TD [(Impact)-189.1(on)-188.7(relationships)-190.3(with)-186.4(others)-190.7(is)-187.6(an)-191.1(area)-191.3(in)-186.4(which)-190.7(people)]TJ -1.1128 -1.2203 TD [(may)-339.6(lack)-342(insight,)-341.5(and)-342.4(it)-335.9(can)-344.8(be)-336.6(very)-344.5(useful)-336.1(to)-344.5(ask)-337.2(a)-343.4(surrogate)]TJ T* [(about)-282.2(this)-279.2(aspect)-281.4(of)-279.8(life.)]TJ ET 62.022 676.97 239.131 .51025 re f 62.022 165.827 239.131 .51024 re f 62.022 165.827 .51024 511.653 re f 300.642 165.827 .51022 511.653 re f BT /F5 1 Tf 8.9663 0 0 8.9663 77.9527 664.2707 Tm [(Specic)-281.8(issues)]TJ /F11 1 Tf 0 -1.8336 TD ()Tj /F4 1 Tf .999 0 TD [(Sometimes)-394.7(people)-391.6(misunderstand)-394.4(what)-387.2(is)-389.9(meant)-389.3(by)-391(this)]TJ 0 -1.2203 TD [(question,)-339.5(and)-336.1(it)-329.5(needs)-338.7(to)-331.8(be)-336.6(explained)-339.7(that)-331(any)-336.1(free-time)]TJ 0 -1.2266 TD [(activity)-263.6(is)-257.1(relevant.)-263.5(The)-260(priority)-260(here)-264.7(is)-257.1(to)-256(identify)-266.1(change)]TJ 0 -1.2203 TD [(in)-344.5(activities)-346.1(outside)-343.3(the)-340.1(home,)-342(but)-337.7(if)-340.8(the)-346.4(person)-338.4(engaged)]TJ T* [(in)-249.6(little)-240.9(or)-248.2(no)-245.6(activity)-244.6(outside)-248.5(the)-245.2(home)-244.3(before)-247.4(injury,)-244.6(then)]TJ T* [(activities)-339.8(at)-334.3(home)-332.8(can)-338.5(be)-330.2(included.)]TJ /F11 1 Tf -.999 -1.2266 TD ()Tj /F4 1 Tf .999 0 TD [()54.8(Outside)-291.9(home)57.1()-293(here)-290(means)-285.3(beyond)-290.3(the)-289.5(persons)-290.6(private)]TJ 0 -1.2203 TD [(space)-606.7(\(with)-599.5(private)-600.1(space)-606.7(potentially)-601.3(including)-604.4(ones)]TJ T* [(garden)-339.6(or)-330.4(yard\).)]TJ /F11 1 Tf -.999 -1.2267 TD ()Tj /F4 1 Tf .999 0 TD [(R)-10.6(a)0(t)-11.8(i)0(n)-9.4(g)-359.9(pe)-7.8(op)-11.7(l)-9.9(e)-356(i)-9.9(n)-353.6(r)-8.4(e)-8.2(ha)-7.8(bi)-15.7(li)-7.1(t)-9.9(a)0(t)-11.8(i)0(o)-9.4(n)-359.9(or)-362(in)-363.4(s)-7(o)0(m)-8.9(e)-362.3(ot)-9.4(he)-14.1(r)-356.2(i)-9.9(nst)-16.4(it)-7.1(u-)]TJ 0 -1.2203 TD [(t)-9.9(i)0(o)-9.4(n)0(a)-14.1(l)-281.7(c)-8.2(a)-8.3(re)-288.6(is)-288.8(di)-15.7(fc)-14.8(ul)-9.4(t)-288.1(b)0(e)-7.8(c)-8.2(a)-8.2(u)0(s)-12.9(e)-280.1(t)-9.9(h)0(e)-286(p)0(e)-14.1(r)-8.4(s)-7(o)0(n)-283.6(h)0(a)-14.1(s)-285.2(no)-11.7(t)-281.7(h)0(a)-14.1(d)-284(th)-9.4(e)]TJ T* [(op)-11.7(po)-11.7(r)-8.4(t)0(u)-9.4(n)0(i)-9.4(t)-9.9(y)-391.5(t)-9.9(o)-391.5(r)-8.4(es)-8.9(um)-15.2(e)-393.9(n)0(o)-11.7(r)0(m)-11.5(a)0(l)-397.5(s)-7(oc)-14.1(ia)-11.8(l)-395.6(a)-8.2(nd)-397.4(le)-11.8(is)-10.6(ur)-14.3(e)-393.9(a)-8.2(ct)-11.8(iv)-9.4(i-)]TJ 0 -1.2266 TD [(t)-9.9(i)0(e)-11.8(s)-7(.)-249.5(U)0(s)-9.8(u)0(a)-14.1(l)0(l)-7.1(y)0(,)-255.3(s)-7(om)-15.2(eo)-7.8(ne)-260.7(in)-249.6(c)-8.2(a)-8.3(re)-257(wi)-12.7(ll)-253.7(be)-254.4(r)-8.4(a)-8.2(te)-11.8(d)-246.1(a)-8.2(s)-247.3(d)0(e)-14.1(p)0(e)-14.1(n)0(d)-11.7(e)0(n)-7.8(t)-9.9(,)]TJ 0 -1.2203 TD [(a)-8.2(n)0(d)-372.1(t)-9.9(he)-374.5(s)-7(o)0(c)-7.8(i)-9.9(al)-372.2(a)-8.3(n)0(d)-372.1(l)0(e)-11.8(i)-9.9(sur)-15(e)-368.7(a)-8.2(ct)-11.8(iv)-9.4(it)-13.4(ie)-11.8(s)-367.4(s)-7(e)-8.2(c)0(t)-11.8(i)0(o)-9.4(n)-366.2(c)-8.2(a)-8.3(n)-366.2(t)0(h)-9.4(e)-8.2(n)-366.2(b)0(e)]TJ T* [(om)-15.2(it)-7.1(t)-9.9(e)-8.3(d.)-350.2(Ho)-8.7(w)-9.1(e)0(v)-7.8(e)-8.2(r)-8.4(,)-344.4(if)-353.4(th)-9.4(e)-343.4(p)0(e)-14.1(r)-8.4(son)-353.8(is)-352(in)-9.4(de)-14.1(pe)-14.1(nde)-13.6(nt)-9.4(,)-350.7(t)0(h)-9.4(e)-8.3(n)-340.9(a)-8.3(n)]TJ T* [(e)-8.2(f)-8.4(fo)-7.9(r)-8.4(t)-338.6(s)-7(hou)-11.2(l)-9.9(d)-334.6(be)-342.9(m)-9.4(a)0(d)-7.8(e)-343.4(to)-338.2(r)-8.4(a)-8.2(te)-340.6(t)-9.9(h)0(e)-7.8(m)-338.2(on)-346.8(th)-9.4(e)-337(b)0(a)-14.1(s)-7(is)-339.3(of)-349.4(wh)-8.6(a)-8.3(t)]TJ 0 -1.2266 TD [(t)-9.9(h)0(e)-7.8(y)-315.7(ex)-7.8(pe)-14.1(c)-8.2(t)-307(t)-9.9(h)0(e)-7.8(y)-309.3(w)-9.1(o)0(u)-11.7(l)0(d)-312.9(b)0(e)-317.6(a)-8.3(bl)-9.4(e)-311.7(t)-9.9(o)-309.3(d)0(o)-315.2(i)0(f)-315.5(t)-9.9(he)-7.8(y)-309.3(w)-9.1(e)-8.3(r)0(e)-313.9(l)-9.9(iv)-9.4(in)-9.4(g)]TJ 0 -1.2203 TD [(a)-8.2(t)-338.6(ho)-11.7(me)-11.3(.)]TJ /F11 1 Tf -.999 -1.2203 TD ()Tj /F4 1 Tf .999 0 TD [(Measuring)-407.3(extent)-408.3(of)-406.3(participation)-403(in)-407.7(terms)-403.3(of)-406.3(occasions)]TJ 0 -1.2266 TD [(per)-364(week)-360.3(emphasizes)-368.8(a)-356(quantiable)-366.6(aspect)-363.6(of)-362(social)-358.9(and)]TJ 0 -1.2203 TD [(leisure)-436.9(activities.)-431.2(Sometimes,)-435.5(quality)-428.4(of)-431.6(participation)-434.6(is)]TJ T* [(affected)-482.9(by)-473.2(brain)-474.5(injury;)-479.1(for)-471.6(example,)-475.9(the)-479.2(person)-477.5(may)]TJ 0 -1.2266 TD [(become)-380.9(a)-375(spectator)-381.4(in)-376.1(a)-375(sport)-378.4(rather)-377.9(than)-377.5(an)-374.5(active)-379.1(par-)]TJ 0 -1.2203 TD [(ticipant.)-317.1(However,)-317(changes)-314.8(such)-317.8(as)-312.4(this)-317.1(are)-315.8(very)-312.9(difcult)]TJ T* [(to)-344.5(quantify)-350.6(and)-342.4(can)-344.8(reect)-351(the)-346.4(especially)-346.8(demanding)-349.4(na-)]TJ 0 -1.2266 TD [(ture)-304.3(of)-305.1(some)-302.4(sports.)-299.8(Thus,)-305.5(for)-300.9(the)-302.1(sake)-307.6(of)-298.8(simplicity,)-303.5(it)-304.2(is)]TJ 0 -1.2203 TD [(the)-270.5(fact)-268.7(of)-267.2(participation)-270.2(that)-267.7(is)-263.5(rated)-268.3(in)-268.6(the)-264.2(interview.)-274.2(One)]TJ T* [(of)-400(the)-397(main)-400(consequences)-400.6(of)-393.6(brain)-398.6(injury)-399.7(is)-396.2(withdrawal)]TJ T* [(from)-354.5(activities)-352.5(involving)-349.1(social)-352.6(interaction,)-352.3(and)-348.7(the)-352.7(sim-)]TJ 0 -1.2266 TD [(ple)-333.8(approach)-341.1(here)-334.3(is)-333(sensitive)-337.3(to)-331.8(such)-336.8(changes.)]TJ /F11 1 Tf -.999 -1.2203 TD ()Tj /F4 1 Tf .999 0 TD .0225 Tc [(Social)-271.9(and)-267.9(l)0(eisure)-270.3(activitie)]TJ 11.2548 0 TD .022 Tc [(s)-269.6(w).2(ill)-272.4(vary)-268.4(depending)-268.4(o)-2.8(n)-268.4(t)-.5(he)]TJ -11.2548 -1.2203 TD .0237 Tc [(ag)5.2(e)-534.6(a)2.8(nd)-525.9(backgro)5.2(und)-525.9(of)-528.5(the)-528.3(p)5.2(articipant.)-529.3(Co)5.2(ns)4(iderin)5.2(g)]TJ 0 -1.2267 TD .0227 Tc [(activities)-351(a)1.8(t)-353.9(h)4.2(ome)-352.3(i).2(s)-351.1(p)4.2(articularly)-349.9(relevant)-347.6(in)-349.9(older)-346.1(a)-4.5(ge)]TJ 0 -1.2203 TD .0242 Tc [(grou)5.7(ps)4.5(.)]TJ /F11 1 Tf -.999 -1.2203 TD 0 Tc ()Tj /F4 1 Tf .999 0 TD .012 Tc [(As)5(ses)5(s)-1.3(ing)-341.6(p)-.2(eople)-344(w)2.9(ho)-341.6(had)-341.6(p)]TJ 11.944 0 TD .0116 Tc [(roblems)-343.2(o)11.6(f)-350.4(a)3.4(lcohol)-339.7(or)-338.3(drug)]TJ -11.944 -1.2266 TD .0122 Tc [(dependence)-267.9(b)12.2(e)-8.2(f)-2.6(o)12.2(r)-8.4(e)-267.9(i)2.3(njury)-265.5(can)-265.5(b)12.2(e)-273.8(pro)12.2(b)-5.8(lematic,)-268.9(g)12.2(i)-9.8(v)12.2(e)-8.2(n)-265.5(that)]TJ 0 -1.2203 TD .0105 Tc [(pre-injury)-558.1(activit)-5.7(ies)-559.3(m)1.1(ay)]TJ 11.2927 0 TD .0112 Tc [(have)-553.5(revolved)-557.4(a)3(rou)11.2(n)-6.8(d)-557.4(t)1.3(heir)]TJ -11.2927 -1.2203 TD .012 Tc [(dependence.)-433.5(It)-427.8(is)-431.3(acceptable)-432.5(to)-436.4(u)12(s)-7.2(e)-432.5(j)-4.2(u)12(d)-6(gment)-427.8(i)-4.2(n)-430.1(t)2.1(hes)5(e)]TJ T* .0115 Tc [(cases.)-269.6(S).8(ometimes)-273.7(it)-276.6(may)-272.5(not)-270.2(be)-275(sensible)-275(to)-272.5(co)11.5(m)-10(p)-.7(let)-4.7(e)-268.6(t)-4.7(h)11.5(e)]TJ 0 -1.2267 TD .011 Tc [(secti)-5.2(o)-1.2(n)-367.9(o)11(n)-380(s)4(ocial)-365.6(a)-3.6(n)11(d)-380(lei)-5.2(s)4(ure)-370.3(a)2.8(ctiviti)-5.2(es)-369.1(as)-369.1(it)-371.9(st)-5.2(ands,)-371.3(but)]TJ 0 -1.2203 TD .0122 Tc [(one)-242.6(would)-240.2(s)5.2(till)-237.9(cons)5.2(id)12.2(e)-8.2(r)-236.5(overall)-237.9(change)-236.3(in)-233.9(functio)12.2(n)-246.1(when)]TJ T* .012 Tc [(cons)5(id)12(e)-8.4(r)3.6(in)12(g)-423.3(t)2.1(he)-407.2(rating)-411.1(on)-411.1(the)-413.6(GOSE.)-414.6(In)-411.1(princip)12(l)-10(e,)-414.6(o)12(n)-6(e)]TJ 0 -1.2266 TD .0124 Tc [(ask)12.4(s)-449.4(about)-440.1(activ)12.4(i)-9.6(ties)-443.5(b).2(efo)12.4(r)-8.2(e)-444.8(i)]TJ 12.4941 0 TD .0116 Tc [(njury)-443.2(a)-3(nd)-443.2(activ)11.6(i)-10.4(ties)-444.3(n)11.6(o)-6.4(w)-3.9(,)]TJ -12.4941 -1.2203 TD .0122 Tc [(and)-328.7(w)-3.3(hether)-331.4(thes)5.2(e)-337.5(h)12.2(a)-8.2(v)0(e)-331.2(c)-2.4(h)12.2(a)-8.2(nged.)]TJ ET 313.058 731.735 239.131 .51025 re f 313.058 685.417 239.131 .51025 re f 313.058 685.417 .51025 46.828 re f 551.679 685.417 .51019 46.828 re f BT /F5 1 Tf 8.9663 0 0 8.9663 329.0456 719.036 Tm 0 Tc (Skipping)Tj /F4 1 Tf T* [(If)-326.7(the)-333.8(person)-332.1(claims)-337.1(no)-327.8(problems,)-335.2(assume)-330.3(that)-331(they)-333.3(did)-331.4(not)]TJ -1.1128 -1.2266 TD [(have)-281.1(problems)-281.7(before)-279(injury)-285.9(\(7c)]TJ /F7 1 Tf 13.1517 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(no\))-279.3(and)-285.5(skip)-275.1(Question)-282.9(7b.)]TJ /F3 1 Tf -42.5342 5.8613 TD (2442)Tj 47.093 0 TD [(WILSON)-336.9(ET)-338.7(AL.)]TJ ET endstream endobj 84 0 obj <>stream /GS1 gs BT /F1 1 Tf 8.9663 0 0 8.9663 69.7323 649.9841 Tm 0 0 0 rg 0 Tc 0 Tw [(Follow-up)-572.3(questions.)]TJ /F4 1 Tf 10.4265 0 TD [(The)-519.2(symptom)-514.7(list)-523.5(on)-517.5(the)-517.1(interview)]TJ -11.5393 -1.2203 TD [(schedule)-293.1(can)-287.9(be)-292.3(used:)]TJ /F8 1 Tf 9.124 0 TD [(Do)-286.9(you)-291.8(have)-287.4(any)-291.8(of)-287.6(the)-289.5(following)-288.3(problems)]TJ -9.124 -1.2203 TD [(from)-221.5(the)-226.3(injury:)-219.5(headaches,)-221.9(dizziness,)-222.4(tiredness,)-223.6(sensitivity)-226.7(to)-224.3(noise)]TJ T* [(or)-303.7(light,)-303.4(slowness,)-304.6(memory)-306.9(failures,)-306.7(and)-302(concentration)-305(problems)]TJ /F4 1 Tf 26.2211 0 TD (?)Tj -26.2211 -1.2266 TD [(Th)20.1(e)-191.6(l)0(i)18.2(s)0(t)-181.3(o)13.1(f)-191.8(p)13.1(ro)17.3(b)13.1(l)0(e)19.8(m)0(s)-180.8(h)13.1(er)21.2(e)-191.6(i)0(n)22.2(c)0(l)19.8(u)13.1(de)17.5(s)-190.4(t)0(h)22.2(o)13.1(se)-186(re)21.2(p)13.1(o)13.1(r)0(t)19.6(e)0(d)-184.8(f)0(o)23.7(r)-191.8(p)13.1(o)0(s)18.8(t)15.4(-c)21.2(on)19.9(cu)23.9(ss)17.6(io)22.3(n)]TJ 0 -1.2203 TD [(sy)18.8(n)13.1(d)0(r)23.7(o)0(m)16.4(e)0(.)]TJ 1.1128 -1.2203 TD [(Conrm)-303.7(any)-298.1(symptoms)-300.4(that)-299.4(impact)-304.3(daily)-298.9(life:)-299.2(Do)-305.8(you)-295.7(nd)-300.6(that)]TJ -1.1128 -1.2267 TD [(that)-286.7(\(symptom\))-278.7(has)-280.3(an)-279.6(effect)-285.4(on)-277.2(what)-286(you)-276.7(do)-277.2(in)-281.2(daily)-279.9(life?)]TJ 1.1128 -1.2203 TD [(Examples)-426.8(include:)-430.3(A)-426.4(movement)-423(problem)-426.5(that)-425.8(interferes)-430.4(with)]TJ -1.1128 -1.2203 TD [(tasks)-467.9(involving)-469.2(ne)-467.4(motor)-463(control)-464.9(\(such)-471.7(as)-464.2(shaving\))-467.9(would)-466.5(be)]TJ 0 -1.2266 TD [(counted,)-299.2(while)-302.2(a)-292.8(change)-301.5(that)-299.4(the)-295.8(person)-300.5(describes)-296.4(as)-299.8()54.8(not)-295.5(bother-)]TJ 0 -1.2203 TD [(some)49.6()-280.3(would)-276.8(not.)]TJ /F5 1 Tf 1.1128 -1.2203 TD [(Q8b.)-281.8(Were)-283(similar)-279.9(problems)-283.6(present)-283(before)-283.7(the)-280.3(injury?)]TJ /F4 1 Tf T* [(Conrm)-253.1(that)-261.4(any)-253.9(problems)-256.5(or)-254.5(symptoms)-249.8(reported)-256.8(are)-258.9(new)-257.2(since)]TJ -1.1128 -1.2266 TD [(the)-397(injury,)-396.3(or)-393.6(at)-397.5(least)-397.3(have)-401.2(become)-393.6(signicantly)-400.5(worse)-392.8(after)-403.6(the)]TJ 0 -1.2203 TD [(injury.)-263.6(When)-268(you)-264.1(ask)-261.4(whether)-264.3(these)-266.8(problems)-269.1(were)-261.7(present)-268.5(before)]TJ T* [(and)-487.8(the)-485.5(answer)-483.2(is)-484.8()54.8(yes)56.9()-482.7(\(to)-485.7(headaches)-489.4(for)-484.3(example\);)-484.9(if)-486.2(these)]TJ 0 -1.2266 TD [(headaches)-388.3(are)-379(worse)-386.4(now)-374.9(or)-381(more)-386(frequent,)-379.8(mark)-379.7(the)-384.3(pre-injury)]TJ 0 -1.2203 TD [(question)-285.9(8b)-277.2(as)-280.8(a)-280.1()54.8(no.)57.1()]TJ /F3 1 Tf 0 -25.7722 TD [(Special)-340(Issues)-330.4(for)-337.3(Assessment)]TJ /F10 1 Tf 0 -1.8336 TD [(Rating)-339.1(people)-335.2(who)-327.8(were)-336.2(severely)-333.4(disabled)]TJ 0 -1.2203 TD [(before)-333.1(injury)]TJ /F4 1 Tf 1.1128 -1.8336 TD -.0201 Tc 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Tc [(a)-4.9(s)-414.6(a)-415.8(s)-3.6(epar)-5(ate)-415.9(c)-4.9(at)-6.5(egory.)]TJ 6.7246 0 0 5.9768 141.3921 137.9905 Tm 0 Tc (8)Tj 8.9663 0 0 8.9663 148.2519 134.022 Tm -.0219 Tc [(H)-5.7(o)-2.4(wever,)-416.8(in)-413.4(practi)-6.5(ce)-415.8(it)-417.4(is)-414.6(often)-413.4(h)-2.4(el)-6.5(pful)-417.5(if)]TJ -9.8701 -1.2203 TD -.0202 Tc [(patients)-280.1(c)-3.2(an)-278.9(also)-278.9(b)5.6(e)-281.4(as)4.4(similated)-279(i)1.6(nto)-278.9(t)1.6(he)-281.4(s)4.4(t)1.6(and)5.6(a)-3.2(rd)-278.9(scale)-281.4(f)3(or)-281.6(analy)5.6(s)-1.9(is.)]TJ 1.1128 -1.2266 TD 0 Tc [(In)-437.9(such)-437.9(cases,)-446.4(assessors)-438.9(are)-442.3(asked)-439.9(to)-439.3(make)-436.4(a)-438.2(judgment)-440(con-)]TJ -1.1128 -1.2203 TD [(cerning)-406.4(the)-397(appropriate)-407.2(rating)-402.2(on)-397.4(the)-403.3(scale.)-405(In)-400(keeping)-403.8(with)-395.1(the)]TJ T* [(general)-276(principles)-275(behind)-269.1(the)-270.5(GOSE,)-271.5(this)-272.8(should)-267.8(focus)-269.3(on)-270.9(changes)]TJ 0 -1.2266 TD [(that)-236.1(have)-236.8(taken)-234(place)-236.5(after)-232.9(injury.)-238.3(Thus,)-229.6(for)-237.7(example,)-235.6(a)-235.9(person)-230.9(who)]TJ 0 -1.2203 TD [(reports)-382.5(no)-378.4(problems)-382.9(or)-374.7(symptoms)-382.6(would)-377.9(be)-380.8(rated)-375.7(as)-382(Upper)-378.9(GR,)]TJ T* [(whereas)-289.1(a)-286.5(person)-287.8(who)-280(reports)-287.6(that)-286.7(their)-282.5(dependence)-291.7(has)-280.3(increased)]TJ 28.0042 74.5534 TD [(signicantly)-204.5(would)-200.9(be)-203.8(rated)-205(as)-205(Upper)-201.9(or)-204(Lower)-201.7(SD.)-199.8(It)-208(is)-200.2(understood)]TJ 0 -1.2203 TD [(that)-248.8(this)-241.2(rating)-250.4(requires)-245.3(judgment,)-247(but)-249.1(it)-247.3(is)-244.5(in)-249.6(keeping)-245.7(with)-243.3(the)-251.6(way)]TJ 0 -1.2266 TD [(that)-280.4(the)-283.2(GOS)-275.6(has)-286.7(traditionally)-278.1(been)-281.1(applied.)]TJ /F10 1 Tf 0 -2.3901 TD [(Rating)-332.7(people)-335.2(who)-334.1(are)-333.4(in)-330.2(hospital)-337.2(or)-335.3(care)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-329.6(GOSE)-338.2(is)-333(not)-331.4(intended)-337.8(for)-332.5(use)-330.9(during)-332.5(acute)-337.6(hospitilization)]TJ -1.1128 -1.2203 TD [(after)-258.2(TBI,)-255.2(but)-255.5(patients)-260.8(who)-254.8(are)-258.9(in)-256(hospital)-252(or)-260.9(care)-254.5(at)-258.4(follow-up)-258.8(can)]TJ T* [(potentially)-278.8(be)-286(assessed.)]TJ 1.1128 -1.2203 TD [(It)-309.2(is)-314.1(often)-310.1(obvious)-317.9(from)-310.3(the)-314.8(level)-313.9(of)-311.5(assistance)-313.6(needed)-314.1(that)-318.3(pa-)]TJ -1.1128 -1.2266 TD [(tients)-335.2(who)-337(are)-341.1(in)-338.2(the)-333.8(hospital)-340.6(or)-336.7(some)-340.3(other)-335.4(form)-341.9(of)-336.7(care)-336.7(are)-341.1(de-)]TJ 0 -1.2203 TD [(pendent.)-368.8(Such)-365.8(patients)-368.3(will)-367.5(therefore)-368.8(be)-368.2(assigned)-367.7(an)-368.2(outcome)-369.4(of)]TJ T* [(either)-290.8(Upper)-296.7(or)-292.5(Lower)-296.6(SD)-291.8(depending)-295.3(on)-296.2(their)-295.1(level)-295(of)-292.5(function)-293.7(in)]TJ 0 -1.2266 TD [(the)-226.3(institution.)-231.5(Given)-228.6(that)-229.8(the)-232.6(person)-230.9(has)-229.8(not)-223.9(had)-234.9(the)-226.3(opportunity)-230.6(to)]TJ 0 -1.2203 TD [(resume)-230.5(life)-232.4(at)-226.8(home,)-234.5(the)-226.3(rest)-235.9(of)-229.2(the)-226.3(interview)-233.4(will)-234.7(often)-227.9(be)-229.1(skipped.)]TJ T* [(These)-281.6(cases)-285.4(are)-277.9(thus)-281.5(an)-286(exception)-282.8(to)-281.3(the)-276.9(recommendation)-286.1(to)-281.2(com-)]TJ 0 -1.2267 TD [(plete)-383.5(the)-378(entire)-385.6(interview.)-381.7(In)-381(general,)-380.1(we)-384.1(strongly)-381(encourage)-380.9(in-)]TJ 0 -1.2203 TD [(terviewers)-551.2(to)-546.8(administer)-550.5(the)-548.7(entire)-550(interview,)-546.1(given)-554.1(that)-546(later)]TJ T* [(responses)-278.5(may)-282.7(lead)-285.1(to)-274.9(re-evaluation)-286.2(of)-279.8(earlier)-282.6(answers.)]TJ 1.1128 -1.2203 TD [(Patients)-202.4(may)-200.5(be)-197.4(in)-205.4(the)-201(hospital)-201.5(when)-199.8(independent)-205.9(for)-199.8(a)-197.9(variety)-208.1(of)]TJ -1.1128 -1.2266 TD [(reasons,)-218(including)-212.4(social)-219.8(circumstances,)-214.9(medical)-217.7(considerations,)-222.7(or)]TJ 0 -1.2203 TD [(in-patient)-347.4(rehabilitation.)-352.5(Patients)-347.9(who)-349.6(are)-347.4(about)-345.4(to)-350.8(be)-342.9(discharged)]TJ T* [(may)-390.2(well)-397.5(also)-397.7(be)-393.5(independent.)-392.2(In)-393.6(these)-399.6(cases,)-395.8(it)-392.8(is)-389.9(necessary)-402.3(to)]TJ 0 -1.2266 TD [(complete)-350(the)-352.7(later)-348.2(parts)-355.5(of)-349.4(the)-346.4(interview,)-356.4(adapting)-350.4(aspects)-351.7(of)-349.4(the)]TJ 0 -1.2203 TD [(sections)-409.7(as)-407.3(necessary.)-411.5(Relevant)-408.1(questions)-406.8(include:)-411.3(Is)-407.5(the)-409.6(person)]TJ T* [(cleared)-208.9(to)-199.1(leave)-211.2(the)-201(unit)-202.1(on)-207.7(their)-206.6(own,)-200.8(able)-209.2(to)-199.1(go)-207.7(to)-199.1(the)-207.3(gift)-204.7(shop)-201.6(and)]TJ 0 -1.2267 TD [(make)-303.6(a)-299.1(purchase,)-300.9(and)-304.4(cleared)-303.7(to)-300.2(leave)-299.7(the)-302.2(hospital)-302.6(without)-302.8(super-)]TJ 0 -1.2203 TD [(vision?)-191.6(If)-193.9(the)-194.7(person)-193(is)-193.9(being)-193.7(discharged,)-196.5(the)-194.7(destination)-200.1(is)-187.6(relevant.)]TJ T* [(Discharge)-298.5(to)-300.2(care)-298.8(at)-296.3(home)-301.2(or)-298.8(to)-293.9(another)-298.9(institution)-298.1(normally)-297.2(indi-)]TJ 0 -1.2266 TD [(cates)-281.9(continued)-280.4(dependence.)]TJ 1.1128 -1.2203 TD [(Persons)-344(who)-343.3(are)-347.4(detained)-346.5(in)-344.5(prison)-346.3(or)-343.1(a)-343.4(similar)-347.2(institution)-348.7(are)]TJ -1.1128 -1.2203 TD [(usually)-425.5(independent,)-430.2(and)-424.6(the)-428.6(interview)-429.4(will)-430.7(need)-426.5(to)-426.7(be)-425.1(adapted)]TJ T* [(appropriately)-283.7(to)-281.3(t)-279.8(the)-276.9(circumstances.)]TJ /F10 1 Tf 0 -2.3901 TD [(Rating)-332.7(people)-335.2(who)-334.1(have)-335.2(an)-331.3(illness)]TJ 0 -1.2266 TD [(unconnected)-328.8(to)-336.7(the)-334.8(injury)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(If)-377.3(the)-378(person)-376.3(has)-381.5(an)-374.5(illness)-380.2(that)-381.6(is)-377.3(clearly)-381.2(unconnected)-381.4(to)-376.1(the)]TJ -1.1128 -1.2203 TD [(injury,)-390(this)-393(should)-394.3(be)-393.5(discounted)-394.9(when)-389.5(making)-392.7(a)-394(rating:)-393(for)-395.8(ex-)]TJ T* [(ample,)-259.5(if)-252.2(the)-257.9(person)-256.2(is)-257.1(off)-256.7(of)-254.5(work)-256.9(because)-260.4(of)-254.5(u)-256.8(when)-256.7(the)-257.9(follow-)]TJ 0 -1.2266 TD [(up)-220.3(is)-219.2(scheduled,)-219.6(or)-222.9(the)-219.9(person)-224.6(has)-217.1(had)-222.3(an)-222.7(operation)-219.7(for)-218.7(an)-222.7(unrelated)]TJ 0 -1.2203 TD [(condition)-206.1(such)-210.3(as)-211.3(a)-210.6(hip)-211.2(replacement.)-213.5(The)-209.4(assessor)-210.6(can)-212(ask)-204.5(about)-212.7(the)]TJ T* [(persons)-189.5(level)-187.5(of)-185(functional)-191.7(recovery)-185.6(before)-190.5(the)-188.3(illness)-190.5(or)-185(operation,)]TJ T* [(and)-241.2(the)-245.2(limitations)-240.9(that)-242.5(they)-244.8(believe)-245.8(are)-246.2(now)-242.1(attributable)-245.4(to)-243.3(illness.)]TJ /F10 1 Tf 0 -2.3901 TD [(Rating)-332.7(people)-335.2(who)-334.1(have)-335.2(injuries)-334.6(to)-330.4(other)-335.1(parts)]TJ 0 -1.2266 TD [(of)-330.4(the)-334.8(body)-335.2(\(peripheral)-336.7(injuries/systemic)-336.4(illness\))]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-297.9(GOSE)-300.2(rating)-301(is)-301.4(based)-300.8(on)-302.5(changes)-302.2(post-injury)-297.6(and,)-301(as)-299.8(orig-)]TJ -1.1128 -1.2203 TD [(inally)-441.5(described,)-443.6(does)-437.9(not)-445.2(distinguish)-443.1(between)-441.1(brain)-442.9(injury)-437.7(and)]TJ T* [(other)-215.3(types)-220.2(of)-222.9(injury)-216.4(that)-217.2(occurred)-223.5(at)-220.4(the)-220(same)-216.3(time.)-223.6(The)-215.7(GOSE)-224.4(can)]TJ T* [(be)-469.3(used)-475.9(in)-470.9(this)-468.9(way)-472.1(to)-470.9(assess)-474.6(the)-472.9(consequences)-476.5(of)-469.5(all)-470.6(injuries)]TJ 0 -1.2266 TD [(\()59(GOSE-All)50.3(\),)-373.9(including)-370.5(polytrauma)-380.9(and)-367.7(any)-374(side)-372.4(effects)-381(of)-368.4(an)]TJ 0 -1.2203 TD [(intervention.)-241.9(Alternatively,)-244.8(the)-238.9(assessor)-242.2(can)-243.6(choose)-243.4(to)-237(focus)-244(on)-239.3(the)]TJ T* [(specic)-336.4(effects)-330.4(of)-336.7(TBI)-334.5(\()59(GOSE-TBI)48.2(\).)-329.6(The)-335.9(decision)-332.6(about)-332.8(whe-)]TJ 0 -1.2266 TD [(ther)-241(to)-243.3(assess)-246.9(GOSE-All)-249(or)-241.9(GOSE-TBI)-244.8(will)-247.4(depend)-242.2(on)-245.6(the)-245.2(purpose)]TJ 0 -1.2203 TD [(of)-279.8(the)-276.9(study.)-283.9(The)-279(approach)-284.2(taken)-284.6(should)-274.2(be)-286(clearly)-280(specied.)]TJ /F10 1 Tf 0 -2.6114 TD [(Glasgow)-331.8(Outcome)-337.1(Scale-Extended/traumatic)]TJ 0 -1.2203 TD [(brain)-334.8(injury:)-330.4(the)-334.8(primary)-333.7(assessment)]TJ 0 -1.2266 TD [(concerns)-334.5(the)-328.5(impact)-339.3(of)-330.4(brain)-334.8(injury)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(An)-331.1(effort)-333.8(should)-331.1(be)-336.6(made)-335.2(to)-331.8(discount)-336.5(the)-333.8(effects)-336.7(of)-330.4(peripheral)]TJ -1.1128 -1.2203 TD [(injuries)-336.8(that)-331(occurred)-337.3(at)-334.3(the)-333.8(same)-336.4(time)-334.5(as)-337.7(the)-333.8(TBI)-334.5(\(e.g.,)-334.8(a)-337(person)]TJ ET 59.754 436.932 239.131 .51022 re f 59.754 249.165 239.131 .51024 re f 59.754 249.165 .51024 188.277 re f 298.375 249.165 .51022 188.277 re f BT /F5 1 Tf 8.9663 0 0 8.9663 75.7417 424.2329 Tm [(Specic)-281.8(issues)]TJ /F4 1 Tf T* [(Similar)-243.4(problems)-237.5(are)-246.2(reported)-244.1(in)-243.3(the)-238.9(general)-244.4(population.)-246.5(It)-239.6(is)]TJ -1.1128 -1.2266 TD [(thus)-370(important)-376.6(to)-376.1(establish)-375.3(that)-368.9(the)-378(problems)-370.3(have)-375.9(developed)]TJ 0 -1.2203 TD [(since)-368(the)-365.4(injury,)-364.7(and)-367.7(to)-369.8(exclude)-368.3(common)-367(problems)-363.9(and)-367.7(com-)]TJ T* [(plaints)-277.8(that)-286.7(were)-280.7(present)-281.1(before)-285.3(injury.)]TJ 1.1128 -1.2266 TD [(Sometimes)-249.3(people)-252.5(report)-255.3(minor)-248(issues,)-256.6(and)-253.9(judgment)-250.4(should)]TJ -1.1128 -1.2203 TD [(be)-279.6(applied)-281.3(as)-280.8(to)-281.3(what)-279.7(counts.)]TJ 1.1128 -1.2203 TD [(It)-239.6(is)-244.5(not)-242.8(necessary)-250.5(to)-243.3(be)-248(exhaustive)-245.5(in)-243.3(identifying)-243.4(symptoms.)]TJ T* [(The)-272.6(symptoms)-268.8(listed)-272(are)-277.9(not)-268.1(specic)-273.2(to)-274.9(brain)-272.2(injury)-273.3(and)-272.8(can)]TJ -1.1128 -1.2266 TD [(arise)-269.4(from)-272.3(other)-265.8(causes,)-275.2(such)-267.2(as)-274.5(depression.)-271.1(If)-269.8(the)-270.5(person)-268.8(gives)]TJ 0 -1.2203 TD [(some)-315(other)-322.7(explanation,)-320.4(for)-313.6(example,)-324.1(bereavement,)-323.3(or)-317.8(anxiety)]TJ T* [(over)-211.7(a)-204.3(pending)-211.7(court)-208.9(case,)-211.7(then)-213.1(the)-207.3(symptoms)-211.9(are)-208.3(not)-211.2(counted)-207.8(in)]TJ 0 -1.2266 TD [(the)-416(rating.)-417.7(However,)-424.5(the)-416(assessor)-419.3(is)-415.2(not)-419.9(expected)-420.8(to)-414(make)-423.7(a)]TJ 0 -1.2203 TD [(detailed)-205.1(investigation)-209.5(of)-204(this)-209.6(point)-201.6(or)-204(make)-208.7(a)-204.3(ne)-208.2(judgment)-206.1(as)-205(to)]TJ T* [(cause.)-325.1(If)-320.4(there)-325.2(is)-320.4(any)-323.4(doubt,)-327(symptoms)-319.4(arising)-327(after)-321.4(the)-327.4(injury)]TJ 0 -1.2266 TD [(should)-280.5(be)-279.6(included)-280.9(in)-281.3(the)-283.2(rating.)]TJ ET 59.754 731.735 239.131 .51025 re f 59.754 675.496 239.131 .51019 re f 59.754 675.496 .51024 56.75 re f 298.375 675.496 .51022 56.75 re f BT /F5 1 Tf 8.9663 0 0 8.9663 75.7417 719.036 Tm (Skipping)Tj /F4 1 Tf 0 -1.2203 TD [(If)-402.6(the)-403.3(person)-407.9(reports)-401.4(that)-406.8(they)-402.8(do)-403.7(not)-407.2(have)-401.2(any)-405.6(problems,)]TJ -1.1128 -1.2266 TD [(assume)-507.3(that)-508(they)-504(did)-508.4(not)-508.4(have)-508.7(any)-506.8(problems)-503(before)-512.9(injury)]TJ 0 -1.2203 TD (\(8b)Tj /F7 1 Tf 1.4985 0 TD (=)Tj /F4 1 Tf .7208 0 TD (no\).)Tj /F3 1 Tf -2.8896 7.088 TD [(MANUAL)-341(FOR)-334(THE)-335.2(GOSE)-330.7(INTERVIEW)]TJ 52.4612 0 TD (2443)Tj ET endstream endobj 88 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(with)-249.7(otherwise)-255.8(GR)-253.6(is)-250.8(unable)-252.5(to)-256(return)-249(to)-249.6(work)-256.9(because)-254(of)-248.2(a)-254.8(broken)]TJ 0 -1.2203 TD [(leg\).)-300.9(Only)]TJ /F8 1 Tf 4.4134 0 TD (discount)Tj /F4 1 Tf 3.6926 0 TD [(disability)-303.4(that)-305.7(is)-301.4(clearly)]TJ /F8 1 Tf 9.8574 0 TD (unrelated)Tj /F4 1 Tf 4.1478 0 TD [(to)-300.2(brain)-297.5(in-)]TJ -22.1112 -1.2266 TD [(jury.)-374.3(If)-377.3(there)-375.7(is)-377.3(any)-374(doubt,)-371.2(the)-378(effects)-374.7(should)-375.3(be)-374.5(included)-375.7(in)-376.1(the)]TJ 0 -1.2203 TD [(rating.)-430.4(Complaints)-430(that)-432.1(are)-429.6(hard)-426.7(to)-433(separate)-430.9(as)-426.3(to)-433(whether)-428.7(they)]TJ T* [(might)-236.8(be)-241.7(attributable)-239.1(to)-237(peripheral)-243.2(injuries)-242(\(such)-237.7(as)-236.6(fatigue,)-242.6(lack)-240.9(of)]TJ 0 -1.2266 TD [(initiative,)-317.9(or)-317.8(depression\))-314.6(would)-321(almost)-315.7(always)-320.2(be)-317.6(considered)-313.7(TBI)]TJ 0 -1.2203 TD [(related.)-257.7(We)-256.3(recognize,)-255.1(however,)-256.8(that)-255.1(in)-256(practice)-256.7(it)-253.7(may)-251.1(be)-254.4(difcult)]TJ T* [(to)-319.2(disentangle)-325(effects)-324.1(of)-324.1(systemic)-324.7(injuries)-324.2(from)-322.9(those)-321.3(of)-317.8(brain)-322.8(in-)]TJ 0 -1.2266 TD [(jury,)-311.1(and)-310.8(that)-305.7(attempting)-316.7(to)-306.5(do)-308.8(so)-310(risks)-310.1(introducing)-308.9(an)-311.3(element)-312.6(of)]TJ 0 -1.2203 TD (subjectivity.)Tj /F1 1 Tf 1.1128 -2.447 TD (Procedure.)Tj /F4 1 Tf 5.874 0 TD .0164 Tc [(As)-218.2(part)-221.1(of)-219.7(th)4.2(e)-225.8(i).2(n)4.2(t).2(ervi)6.5(ew,)-220.5(a)1.8(s)3.1(k)-223.4(th)4.2(e)-225.8(p)4.2(atient)-221.1(wh)4.2(ether)]TJ -6.9868 -1.2203 TD .0162 Tc [(they)-653.5(have)-656(limi)6.3(t)0(at)6.3(ions)-654.7(that)-651.2(th)]TJ 13.2212 0 TD .0156 Tc [(ey)-654.1(believe)-656.6(are)-656.6(a)1(ttri)5.7(b)-2.9(utable)-656.6(to)]TJ -13.2212 -1.2203 TD [(injuries/ill)5.8(ness)-225.3(to)-217.8(other)-220.4(p)-2.8(arts)-218.9(of)]TJ 13.0378 0 TD .0148 Tc [(the)-227.4(body)-218.7(a)-6.1(nd)-225(not)-222.7(the)-221.1(b)2.6(rain)-218.7(injury.)]TJ -13.0378 -1.2203 TD .0151 Tc [(If)-227.3(they)-224.7(have)-227.1(disability)-224.7(att)5.2(r).3(ibutab)]TJ 13.2339 0 TD .0153 Tc [(le)-220.6(to)-224.5(peripheral)-222.2(i)-.9(nj)5.4(uries,)-227.9(ask)-224.5(h)-3.2(ow)]TJ -13.2339 -1.2266 TD .0151 Tc [(they)-199.4(think)-205.7(t)-1.1(hey)-205.7(w)-.4(ould)-205.7(d)2.9(o)-199.4(w)-.4(ithout)-203.4(thos)]TJ 15.4216 0 TD .0161 Tc [(e)-200.8(limitati)6.2(ons,)-195.5(concentrating)]TJ -15.4216 -1.2203 TD .0153 Tc [(on)-243.4(sections)-251(that)-247.5(have)-252.2(an)-249.8(i)5.4(m)-.4(pact)-247.5(on)-243.4(the)-245.9(r).5(ating.)-246.9(If)-246.1(the)-252.2(p)3.1(erson)-249.8(i)-.9(s)-244.6(n)-3.2(ot)]TJ T* .0146 Tc [(sure)-303.5(whe)-6.3(t)4.7(her)-303.7(t)-1.6(he)-303.5(problem)-304.6(a)0(rises)-302.2(f)-6.5(rom)-304.6(b)2.4(ra)-6.3(in)-307.4(injury)-307.4(or)-303.7(something)]TJ 0 -1.2266 TD .016 Tc [(else,)-277.8(c)1.4(ount)-278.4(it)-278.4(as)-275.6(attributable)-283.1(to)-274.4(the)-276.8(b)3.8(rain)-274.4(inj)6.1(u)-2.5(ry.)]TJ /F3 1 Tf 0 -2.4406 TD 0 Tc (Discussion)Tj /F4 1 Tf 1.1128 -1.8336 TD [(This)-363.5(Manual)-367(was)-372.2(developed)-367.3(as)-363(part)-367.5(of)-368.4(the)-365.4(CENTER-TBI)-371.1(and)]TJ -1.1128 -1.2267 TD [(TRACK-TBI)-438.5(studies)-433.1(and)-437.2(has)-432.1(been)-432.8(rened)-433.1(and)-437.2(elaborated)-432.7(upon)]TJ 0 -1.2203 TD [(from)-304(the)-308.5(experience)-304.7(in)-306.5(these)-304.8(studies.)-303.2(It)-309.1(is)-301.4(intended)-306.1(to)-306.5(be)-304.9(part)-304.3(of)-305.1(a)]TJ T* [(data-quality)-323.6(management)-325.7(strategy)-328.9(for)-319.9(outcome)-325.1(assessment)-324.5(and)-323.4(to)]TJ 0 -1.2266 TD [(be)-184.8(useful)-184.3(to)-180.1(investigators)-190.3(using)-179.8(the)-182(GOSE)-186.4(in)-186.4(single)-179.4(and)-184.3(multi-center)]TJ 0 -1.2203 TD (studies.)Tj /F10 1 Tf 0 -2.4406 TD [(Training)-335.5(and)-335.7(monitoring)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Im)20.1(p)13.1(l)0(e)13.5(m)15.9(en)17.5(ti)18.2(n)13.1(g)-195.5(ap)17.5(pr)17.3(o)13.1(p)0(r)17.3(i)0(a)19.8(t)0(e)-188.8(s)0(t)21.1(r)0(a)21.2(t)0(e)19.8(g)0(i)15.9(e)0(s)-186(f)0(o)23.7(r)-198.1(d)13.1(a)0(t)13.5(a)0(-)21.2(q)13.1(ua)17.5(li)18.2(ty)-186.4(ma)20.3(n)13.1(a)0(g)17.5(e)0(m)20.3(e)0(n)17.5(t)]TJ -1.1128 -1.2266 TD [(is)-187.6(an)-191.1(im)18.7(p)13.1(o)0(r)17.3(t)0(a)19.8(n)0(t)-186.4(p)0(a)17.5(r)0(t)-189(o)13.1(f)-204.4(a)0(n)23.9(y)-201.8(p)13.1(r)0(o)17.3(j)0(e)19.8(c)0(t)19.8(.)]TJ 6.7246 0 0 5.9768 181.7574 390.0471 Tm (17)Tj 8.9663 0 0 8.9663 190.2047 386.0219 Tm [(S)14.6(i)0(n)15.9(g)13.1(le)19.8(-c)14.9(en)23.9(te)13.5(r)-198.1(s)0(t)21.1(u)13.1(di)15.9(es)-186(ar)14.9(e)-197.9(a)0(b)17.5(l)15.4(e)-204.3(t)0(o)]TJ -14.2961 -1.2203 TD [(ad)17.5(d)13.1(r)0(e)14.9(s)0(s)-241.7(t)0(h)22.2(e)-254.8(is)21.1(su)18.8(e)-254.8(o)0(f)-241.9(i)0(n)15.9(t)15.4(er)14.9(-r)21.1(at)19.8(er)-244.3(di)15.9(ff)21.1(er)21.2(en)17.5(ce)21.4(s)-253.6(b)0(y)-245.6(r)0(e)21.2(s)0(t)21.1(r)0(i)13.3(c)0(t)19.8(i)0(n)22.2(g)-252.4(th)22.2(e)-254.8(n)0(u)19.9(m)0(b)16.4(e)0(r)]TJ T* [(of)-400(as)16.3(se)22.7(ss)17.6(or)17.3(s)-405.4(i)0(n)15.9(v)13.1(ol)15.9(v)13.1(e)0(d)-399.8(a)0(n)17.5(d)-410.5(en)17.5(su)18.8(ri)19.6(n)13.1(g)-410.5(co)17.5(mm)19.2(u)13.1(n)0(i)22.2(c)0(a)15.1(t)0(i)18.2(o)13.1(n)-410.5(o)0(n)-403.7(b)13.1(o)13.1(r)0(d)17.3(e)0(r)21.3(l)0(i)18.2(n)0(e)]TJ 0 -1.2266 TD [(ca)15.1(se)22.7(s)-316.8(a)0(n)17.5(d)-309.3(ot)15.9(h)13.1(e)0(r)-307.5(i)0(s)21.1(s)0(u)18.8(e)0(s)16.3(.)-312.7(T)13.3(h)0(e)-304.9(c)0(u)17.5(r)0(r)21.1(e)0(n)17.5(t)-313.4(Ma)16.8(n)13.1(u)0(a)17.5(l)-313.4(ca)15.1(n)-315.7(p)13.1(ro)17.3(v)13.1(i)0(d)15.9(e)-311.8(su)18.8(p)13.1(p)0(o)19.9(r)0(t)-309.2(t)0(o)]TJ 0 -1.2203 TD [(su)18.8(ch)-267(st)21.1(ud)19.9(ie)19.8(s,)-269.2(an)23.9(d)-277.7(i)0(f)-264.9(a)0(s)16.3(s)0(e)22.7(s)0(s)17.6(o)0(r)17.3(s)-272.6(ar)14.9(e)-273.8(a)0(l)19.8(r)0(e)14.9(a)0(d)23.9(y)-277.7(ex)17.5(p)13.1(e)0(r)14.9(i)15.4(en)17.5(ce)15.1(d)13.1(,)-274.8(th)15.9(er)21.3(e)-273.8(w)0(i)18.9(l)0(l)-266.3(b)0(e)]TJ T* [(no)-334.1(ne)17.5(ed)-336.6(fo)17.3(r)-343.6(f)0(o)17.3(r)0(m)20.1(a)0(l)-340.6(t)15.4(ra)14.9(in)22.2(in)15.9(g)13.1(.)-344.4(Fo)15(r)-343.5(m)0(u)16.4(l)15.4(ti)18.2(-c)14.9(en)23.9(te)19.8(r)-349.9(s)0(t)21.1(u)0(d)19.9(i)0(e)19.8(s)-348.5(in)-338.2(wh)23(ic)13.5(h)-341(t)0(h)15.9(e)]TJ 0 -1.2266 TD [(GO)19.7(SE)-218.7(is)-212.9(a)-229.5(p)13.1(ri)19.6(ma)20.3(ry)-216.6(en)17.5(d)13.1(-)0(p)17.3(o)13.1(in)15.9(t,)-215.1(ma)20.3(xi)22.2(mi)18.7(zi)19.8(ng)-220.3(i)15.4(n)0(t)15.9(e)0(r)21.2(-)0(r)14.7(a)0(t)19.8(e)0(r)-212.7(a)0(g)17.5(r)0(e)21.2(e)0(m)14(e)0(n)23.9(t)-224.8(is)-219.2(a)]TJ 0 -1.2203 TD [(ke)17.5(y)-233.5(i)0(s)14.7(s)0(u)25.1(e)0(.)-232.5(C)14.7(ho)19.9(i)-237.5(a)0(n)17.5(d)-233.5(co)17.5(ll)18.2(ea)21.4(gu)19.9(es)]TJ 6.7246 0 0 5.9768 170.1354 313.2849 Tm (18)Tj 8.9663 0 0 8.9663 178.9228 309.3164 Tm [(sh)18.8(o)13.1(w)0(e)20.5(d)-239.8(th)22.3(at)-226.8(va)17.5(ri)19.6(ab)17.5(il)18.2(it)24.5(y)-239.8(i)0(n)-224.3(o)0(u)19.9(t)0(c)19.8(o)0(m)16.4(e)]TJ -13.0378 -1.2203 TD [(as)16.3(se)22.7(ss)17.6(me)20.3(nt)-218(af)14.9(fe)21.2(ct)19.8(s)-228.3(n)0(o)19.9(t)-231.2(o)13.1(n)0(l)15.9(y)-227.1(th)22.2(e)-229.5(p)0(o)19.9(w)0(e)20.5(r)-229.7(of)-216.6(a)-229.5(s)0(t)14.7(u)13.1(dy)19.9(,)-230.5(b)13.1(ut)-218(al)19.8(so)-221.5(th)22.2(e)-229.5(s)0(i)21.1(z)0(e)-218.8(o)0(f)]TJ T* [(th)22.2(e)-318.1(d)13.1(if)19.6(fe)21.2(re)14.9(n)13.1(c)0(e)15.1(s)-310.5(th)22.3(at)-302.6(ar)14.9(e)-311.8(f)0(o)17.3(u)13.1(nd)19.9(.)-312.7(T)13.3(hu)19.9(s,)-307.1(re)21.2(du)19.9(ci)19.8(ng)-302.5(v)13.1(a)0(r)14.9(i)0(a)19.8(b)13.1(il)18.2(it)18.2(y)-309.3(i)0(s)-307.7(c)0(r)21.3(i)0(t)18.2(i)0(c)19.8(a)0(l)]TJ 0 -1.2266 TD [(an)17.5(d)-227.1(p)0(a)17.5(r)0(t)19.6(i)0(c)19.8(u)0(l)15.9(a)0(r)21.2(l)0(y)-224.3(i)15.4(mp)16.4(o)13.1(r)0(t)19.6(a)0(n)17.5(t)-231.2(fo)17.3(r)-229.7(p)0(h)19.9(a)0(r)21.2(m)0(a)14(c)0(e)21.4(u)0(t)22.3(i)0(c)13.5(a)0(l)-220.4(t)0(r)19.6(i)0(a)19.8(l)0(s)21.1(,)-230.5(wh)16.6(er)21.2(e)-235.9(e)0(x)23.9(p)0(e)17.5(c)0(t)19.8(e)0(d)]TJ 0 -1.2203 TD [(ef)21.2(fe)14.9(ct)-353.2(si)21.1(ze)21.4(s)-361.1(a)0(r)14.9(e)-362.3(sm)21.6(al)19.8(l.)-354.2(E)13.3(x)0(p)19.9(e)0(r)14.9(i)0(e)19.8(n)13.1(ce)-357.9(i)15.4(n)-366.2(mu)22.7(lt)18.2(i-)19.6(ce)21.4(nt)15.9(er)-351.8(st)21.1(ud)19.9(ie)19.8(s)-361.1(s)0(u)18.8(p)0(p)19.9(o)0(r)17.3(t)0(s)]TJ T* [(fo)17.3(u)13.1(r)-274(cr)21.2(it)18.2(ic)19.8(al)-258.4(st)14.7(ep)23.9(s)-272.6(f)0(o)17.3(r)-267.7(d)13.1(a)0(t)13.5(a)0(-)21.2(q)13.1(ua)17.5(li)18.2(ty)-262.3(en)23.9(ha)17.5(nc)17.5(em)20.3(en)17.5(t:)]TJ .999 -1.8336 TD [(1.)-501.9(Specication)-297.6(in)-293.9(advance)-297.1(as)-299.8(to)-293.9(whether)-295.9(ratings)-295.4(should)-299.5(reect)]TJ 1.2519 -1.2267 TD [(disability)-442.5(caused)-448.1(by)-441.6(the)-447.6(consequences)-444.9(of)-444.2(all)-445.3(injuries)-444.3(\(i.e.,)]TJ 0 -1.2203 TD [(brain)-329.1(and)-329.7(peripheral)-338.1(body)-326.8(parts\))-332.4(or)-330.4(only)-330.9(the)-333.8(specic)-330.1(effects)]TJ T* [(of)-330.4(the)-333.8(brain)-335.4(injury.)]TJ -1.2519 -1.2266 TD [(2.)-501.9(Initial)-276.9(training)-278.7(that)-280.4(covers)-283.9(the)-276.9(procedures)-280.7(for)-275.6(completing)-281.1(the)]TJ 1.2519 -1.2203 TD [(assessment)-375.1(and)-374(includes)-376.9(consideration)-377.2(of)-368.4(how)-374.9(to)-376.1(deal)-373.6(with)]TJ T* [(cases)-336(that)-337.3(are)-334.8(borderline)-335.7(or)-330.4(hard)-331.9(to)-338.2(classify.)]TJ -1.2519 -1.2266 TD [(3.)-501.9(A)-426.4(process)-436.4(for)-427.4(accreditation)-435.4(involving)-431.3(satisfactory)-432(comple-)]TJ 1.2519 -1.2203 TD [(tion)-334.9(of)-330.4(assessments,)-340.8(either)-335(case)-335.3(vignettes)-336.2(or)-330.4()54.8(live)50.5()-330.9(cases.)]TJ -1.2519 -1.2203 TD [(4.)-501.9(Central)-554.2(monitoring)-557.1(of)-551.7(assessments)-552.8(for)-553.8(completeness)-561.5(and)]TJ 1.2519 -1.2203 TD [(consistency,)-419.9(including)-414.8(feedback)-419.4(to)-414(assessors)-420(of)-418.9(issues)-418.1(that)]TJ 0 -1.2267 TD [(arise)-288.4(and)-285.5(the)-289.5(opportunity)-281.2(to)-287.6(review)-290(and)-285.5(change)-288.9(assessments.)]TJ -1.1381 -1.8336 TD [(It)-321.8(is)-320.4(important)-326(to)-325.5(decide)-324.5(whether)-327.5(the)-321.1(GOSE-All)-324.9(or)-324.1(GOSE-TBI)]TJ -1.1128 -1.2203 TD [(approach)-296.8(is)-288.8(being)-294.9(used)-292.5(and)-291.8(to)-293.9(communicate)-297.6(this)-291.8(to)-293.9(assessors.)-290.1(The)]TJ T* [(contrast)-328.9(between)-327.3(the)-321.1(two)-322(approaches)-331.1(emerged)-326.1(during)-319.8(harmoniza-)]TJ 0 -1.2266 TD [(tion)-214.7(of)-222.9(the)-213.6(CENTER-TBI)-225.7(and)-215.9(TRACK-TBI)-223.5(projects)-215.1(and)-222.3(appears)-216.3(to)]TJ 0 -1.2203 TD [(reect)-319.4(different)-313.5(practices)-320.6(in)-312.9(Europe)-318.1(and)-317.1(North)-311(America.)-317.4(Anecdo-)]TJ 27.9978 74.5598 TD [(tally,)-236.3(it)-234.7(was)-233.1(known)-234.8(that)-236.1(the)-232.6()54.8(GOSE-All)56.6()-236.1(approach)-233.6(was)-233.1(commonly)]TJ 0 -1.2203 TD [(used)-355.7(in)-350.8(European)-351.1(studies,)-347.5(whereas)-358.7(the)-346.4()54.8(GOSE-TBI)48.2()-349.9(assessment)]TJ 0 -1.2266 TD [(was)-334.2(typical)-335.9(for)-332.5(trials)-331.5(in)-331.8(the)-333.8(United)-333.3(States.)-335.1(However,)-336(past)-334.5(clinical)]TJ 0 -1.2203 TD [(trials)-318.8(have)-306.4(rarely)-314.6(specied)-317(which)-310.8(approach)-315.8(was)-308.9(being)-313.8(used)-311.5(in)-312.9(the)]TJ T* [(formal)-347.4(report.)]TJ 6.7246 0 0 5.9768 363.855 685.9274 Tm (19)Tj 8.9663 0 0 8.9663 373.6629 681.9589 Tm [(This)-344.5(is)-345.7(an)-342.9(important)-345(omission.)-341.8(Studies)-348.3(using)-344.2(the)]TJ -6.7592 -1.2266 TD [(GOSE-All)-236.4(approach)-227.3(may)-225.8(wish)-227.9(to)-230.7(include)-230.8(a)-223.2(measure)-232.5(of)-229.3(extracranial)]TJ 0 -1.2203 TD [(injury)-285.9(as)-280.8(a)-280.1(covariate)-281.5(in)-281.3(the)-283.2(analysis.)]TJ 1.1128 -1.2203 TD [(Steps)-383.1(for)-376.8(improving)-376.5(data)-380(quality)-384.1(are)-379(particularly)-383.1(important)-376.6(in)]TJ -1.1128 -1.2266 TD [(studies)-243.4(in)-237(which)-241.2(the)-245.2(GOSE)-237(is)-238.2(a)-242.2(primary)-239.4(end-point,)-239.2(where)-242.3(there)-243(is)-238.2(a)]TJ 0 -1.2203 TD [(desire)-243.7(to)-230.7(maximize)-239.8(rigor)-234.4(and)-241.2(minimize)-235(variability.)-240.1(For)-233.7(example,)-235.6(in)]TJ T* [(a)-501.4(multi-center)-506.8(trial)-501.5(of)-494.8(dexanabinol)-503.1(in)-502.6(severe)-501.3(brain)-499.8(injury,)-497.5(im-)]TJ T* [(plementation)-482.6(of)-475.8(training)-481.1(and)-475.2(monitoring)-481.2(were)-476.7(found)-480.7(to)-477.3(reduce)]TJ 0 -1.2266 TD [(queries)-458.2(concerning)-451.6(inconsistencies)-452(in)-452(assessment)-451(from)-455.7(30%)-449.6(or,)]TJ 0 -1.2203 TD [(more)-316.4(initially,)-309.6(to)]TJ /F7 1 Tf 7.1639 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(10%)-310.5(later)-316.5(in)-306.5(the)-314.8(study.)]TJ 6.7246 0 0 5.9768 465.5621 587.2817 Tm (20)Tj 8.9663 0 0 8.9663 475.0865 583.3132 Tm [(Similar)-313(experience)-317.3(is)]TJ -18.0709 -1.2203 TD [(reported)-282(by)-277.2(Boase)-280.2(and)-279.2(colleagues,)]TJ 6.7246 0 0 5.9768 437.1589 576.34 Tm (13)Tj 8.9663 0 0 8.9663 446.3999 572.3715 Tm [(who)-280(describe)-283.1(in)-274.9(detail)-279.5(GOSE)]TJ -14.8715 -1.2266 TD [(curation)-283.5(in)-281.3(the)-283.2(TRACK-TBI)-280.4(study.)]TJ 1.1128 -1.2203 TD [(The)-297.9(ini)18.7(tial)-290.7(tra)11.4(ini)12.4(ng)-296.2(sho)12.9(uld)-293.4(inc)14(lud)16.4(e)-305.4(ins)15.2(tru)13.8(cti)16.3(ons)-296.9(as)-299.8(to)-300.2(ho)13.6(w)-306.3(t)0(o)-300.2(ad-)]TJ -1.1128 -1.2203 TD [(min)12.9(iste)15.6(r)-280.3(the)-264.2(GOSE)-268.6(and)-266.5(deri)18.2(ve)-279.6(an)-273.3(ov)13.6(era)13(ll)-279(sco)16.8(re.)-272.5(It)-271.2(is)-276.1(wor)14.5(th)-274.9(emp)14.5(ha-)]TJ 0 -1.2266 TD [(siz)12.8(ing)-192.2(the)-194.7(iss)14(ue)-197.4(of)-197.6(sco)16.8(rin)13.8(g,)-198.4(giv)16.4(en)-197.4(tha)14(t)-199.5(i)0(t)-196.8(wil)15.4(l)-205.9(b)0(e)-197.5(u)0(n)13.6(fam)11.9(ili)14.7(ar)-200(to)-192.7(per)15.4(son)12.9(s)]TJ 0 -1.2203 TD [(accu)13.7(sto)15.2(med)-289(to)-287.6(asse)13.7(ssi)14(ng)-289.9(a)-299.1(GOS)-288.3(in)-293.9(the)-283.2(cla)11.6(ssi)14(c)-299.1(for)15.2(mat)-286.7(of)-292.5(an)-292.3(over)15.9(al)13.5(l)]TJ T* [(judg)16.9(men)14.5(t)-319.7(mad)14.5(e)-318.1(b)0(y)-315.2(the)-308.5(clin)16.8(ici)16.3(an.)-307.9(One)-314.1(of)-311.4(the)-308.5(aspe)14.9(cts)-309.7(of)-311.5(the)-314.8(ass)15.6(ess)15.6(-)]TJ T* [(ment)-273.6(tha)14(t)-281.7(oft)13.8(en)-279.6(su)12.4(rpr)15.2(ise)12.8(s)-285.2(per)15.4(son)12.9(s)-285.2(i)0(s)-276.1(the)-276.9(amo)14.5(un)13.6(t)-288.1(o)0(f)-273.5(disa)13.3(gre)15.4(eme)12.1(nt)-274.9(in)]TJ 0 -1.2266 TD [(scor)14.7(ing)-185.9(dis)15.2(cove)16.1(red)-186.9(bet)14(wee)12.3(n)-195.5(ass)15.6(esso)16.1(rs.)-189.1(It)-189(can)-193.1(be)-191.1(us)12.4(eful)-184.1(to)-192.7(not)16.4(e)-197.9(thi)12.4(s)-196.7(a)0(s)]TJ 0 -1.2203 TD [(a)-311.8(dem)14.5(ons)12.9(tra)11.4(tio)18.7(n)-309.3(vign)16.9(ett)16.3(e)-311.7(ear)13(ly)-306.5(in)-300.2(tra)11.4(ini)12.4(ng)-302.5(to)-306.5(mot)19.2(iva)14(te)-309(the)-302.2(pro)17.8(ces)14.4(s.)]TJ T* [(A)-325.3(m)0(i)12.4(sta)12.8(ke)-317.6(tha)14(t)-319.7(ine)14(xp)13.6(eri)11.4(enc)15.6(ed)-317.6(ass)15.6(ess)15.6(ors)-312.1(oft)13.8(en)-317.6(ma)14(ke)-317.6(is)-314.1(to)-312.9(com)14.5(ple)14(te)]TJ 0 -1.2266 TD [(the)-264.2(int)18.7(ervi)18.2(ew)-264(mec)12.1(hani)14.5(cal)17.9(ly)-262.3(with)15.9(out)-255.5(usin)15.7(g)-265.1(fol)13.8(low)13.1(-up)-260.4(qu)13.6(est)12.8(ion)16.4(s,)-269.2(and)]TJ 0 -1.2203 TD [(in)-243.3(grou)18.3(p)-246.1(tra)11.4(ini)12.4(ng)13.6(,)-249.5(i)0(t)-241(i)0(s)-244.5(u)0(s)12.4(eful)-234.7(to)-243.3(us)12.4(e)-248.5(case)-240.4(st)14.7(udie)14.5(s)-247.3(tha)14(t)-243.8(are)-239.9(amb)14.5(iguo)16.9(us)]TJ T* [(and)-190.6(requ)15.9(ir)13.3(e)-204.3(t)0(r)13.3(ain)14(ees)-194.2(to)-192.7(ide)14(nti)12.4(fy)-191.3(sec)14.4(tio)12.4(ns)-196.2(whe)14.7(re)-193.7(fur)15.2(the)14(r)-198.1(inf)13.8(orm)14.3(atio)16.8(n)-195.5(i)0(s)]TJ 0 -1.2266 TD [(need)16.1(ed)-273.3(to)-274.9(arr)12.8(ive)-270.5(at)-271(a)-280.1(rat)17.7(ing.)-264.7(Oth)13.1(er)-275.9(us)12.4(efu)15.4(l)-281.7(t)0(r)13.3(ain)14(ing)-268.1(ele)11.6(men)14.5(ts)-276.1(inc)14(lud)16.4(e)]TJ 0 -1.2203 TD [(obs)12.9(erv)15.4(atio)16.8(n)-284(o)0(f)-279.8()61.1(li)16.1(ve)66()-280.3(int)12.4(erv)15.4(iews)-274.5(and)-272.8(rec)13(ord)17.8(ing)-274.4(the)-276.9(ass)15.6(esso)16.1(rs)-276.8(own)]TJ T* [(int)12.4(erv)15.4(iews)-186(for)-180.8(dir)13.8(ect)-190.8(fee)13(db)13.6(ack.)-183.3(As)-193.2(the)-182(stu)15.2(dy)-195(pro)17.8(gre)15.4(sses)14.9(,)-192.6(i)0(t)-190.4(i)0(s)-193.9(u)0(s)12.4(efu)15.4(l)-199.5(i)0(f)]TJ 0 -1.2266 TD [(asse)13.7(sso)18.1(rs)-394.8(fro)15.2(m)-395.1(mul)12.9(tip)12.4(le)-391.2(cen)15.6(ter)11.4(s)-399(hav)18(e)-400.3(the)-384.3(opp)14.1(ort)13.8(un)13.6(ity)-392.3(to)-388.7(conv)18.5(ene)]TJ 0 -1.2203 TD [(regu)15.9(lar)11.4(ly)-357.1(wi)12.6(th)-357.1(su)12.4(perv)15.9(iso)15.2(rs/)12.6(pri)13.8(nci)14(pal)-352.7(inv)16.4(est)12.8(iga)14(tor)13.8(s)-361.1(t)0(o)-357.1(dis)15.2(cus)16.8(s)-367.4(pro)17.8(b-)]TJ T* [(lema)14.9(tic)-268.2(cas)14.4(es)-268.2(and)-266.5(oth)16.4(er)-275.9(iss)14(ues)-261.4(ari)11.4(sin)15.2(g)-277.7(w)0(i)12.6(t)0(h)-274.9(ass)15.6(ess)15.6(men)14.5(t.)]TJ 6.7246 0 0 5.9768 509.4991 368.107 Tm (13)Tj /F10 1 Tf 8.9663 0 0 8.9663 313.0582 336.6991 Tm [(Strengths)-340.4(and)-329.4(limitations)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-310.6(GOSE)-312.9(is)-307.7(often)-310.1(criticized)-314.3(for)-307.2(being)-313.8(a)-305.4(relatively)-318.2(coarse)-311.6(out-)]TJ -1.1128 -1.2203 TD [(come.)-211.7(Nonetheless,)-214.5(major)-212.5(strengths)-207.1(of)-210.3(the)-207.3(assessment)-217(are)-208.3(its)-210.1(ability)]TJ T* [(to)-287.6(assign)-290.4(an)-286(outcome)-287.2(in)-287.6(all)-287.2(cases,)-288.3(the)-283.2(fact)-294(that)-286.7(categories)-288.5(are)-284.2(clin-)]TJ 0 -1.2267 TD [(ically)-298.5(meaningful,)-295.3(and)-298.1(that)-293(it)-297.9(focuses)-297.3(on)-296.2(changes)-295.9(post-injury.)-294.2(The)]TJ 0 -1.2203 TD [(latter)-250.5(lends)-245.5(it)-247.3(particular)-253.6(sensitivity)-247.2(to)-243.3(brain)-246.9(injury)-248(severity.)-249.6(Despite)]TJ T* [(the)-390.7(simplicity)-395.4(of)-387.3(the)-390.7(scale,)-392.3(it)-392.8(has)-387.8(proven)-394.1(to)-388.7(be)-393.5(useful)-386.7(in)-388.7(a)-394(wide)]TJ T* [(variety)-233.4(of)-229.3(contexts.)-228.1(In)-229.3(TRACK-TBI,)-232.8(the)-226.3(scale)-231.3(has)-229.8(been)-230.5(found)-227.8(to)-224.3(be)]TJ 0 -1.2266 TD [(useful)-241.3(in)-230.7(mild)-237.2(TBI.)]TJ 6.7246 0 0 5.9768 381.5432 247.5779 Tm (21)Tj 8.9663 0 0 8.9663 390.3873 243.5527 Tm [(In)-235.6(this)-234.9(study,)-233.3(in)-237(addition)-231.9(to)-237(the)-232.6(overall)-233.4(GOSE)]TJ -8.6245 -1.2203 TD [(rating,)-462(responses)-461.9(recorded)-457.5(in)-458.3(the)-453.9()54.8(Relationships)50()-457.4(section)-459.6(were)]TJ T* [(informative)-330.1(as)-325.1(individual)-329.8(outcomes,)-322.4(demonstrating)-327.7(that)-331(more)-322.7(can)]TJ 0 -1.2266 TD [(be)-286(extracted)-281.5(from)-278.7(the)-283.2(assessment)-286.6(than)-276.4(simply)-281.7(a)-280.1(single)-280.6(score.)]TJ 1.1128 -1.2203 TD [(The)-304.3(GOSE)-306.6(is)-301.4(intended)-299.8(for)-307.2(assessing)-300.1(groups)-304.4(of)-298.8(cases)-310.7(in)-300.2(an)-298.6(ef-)]TJ -1.1128 -1.2203 TD [(cient)-282.3(manner,)-276.5(and)-279.2(there)-274.6(are)-277.9(limits)-277.1(to)-274.9(the)-276.9(precision)-284.2(that)-274.1(is)-276.1(achieved)]TJ 0 -1.2266 TD [(on)-403.7(the)-403.3(basis)-398.4(of)-400(a)-406.6(short)-397.4(interview.)-407(Some)-400.9(of)-400(the)-397(criticisms)-403.9(of)-406.3(the)]TJ 0 -1.2203 TD [(GOSE)-281.3(are)-284.2(based)-281.8(on)-277.2(a)-280.1(misunderstanding)-283.2(of)-273.5(the)-283.2(intended)-280.9(use)-280.3(of)-279.8(the)]TJ T* [(scale)-452.6(and)-449.9(unrealistic)-451.7(expectations)-453.3(of)-450.6(precision)-448.6(from)-449.4(a)-450.9(brief)-451.8(as-)]TJ T* [(sessment.)-369(As)-363.9(already)-370.9(described,)-367.7(some)-359.3(cases)-367.6(fall)-365.2(readily)-366.1(into)-366.5(one)]TJ 0 -1.2266 TD [(category)-199.7(or)-197.6(another.)-194.3(Borderline)-201.3(cases)-196.9(give)-194.2(rise)-198(to)-199.1(uncertainty)-193.6(of)-197.6(one)]TJ 0 -1.2203 TD [(category,)-297.4(and)-291.8(differences)-289.2(of)-292.5(one)-291.8(category)-294.5(can)-287.9(be)-292.3(considered)-294.7(to)-287.6(be)]TJ T* [(within)-278(the)-276.9(normal)-275.2(measurement)-278.4(error)-279.7(of)-273.5(the)-276.9(assessment.)-276.8(For)-277.9(some)]TJ 0 -1.2266 TD [(studies,)-315.8(this)-310.8(level)-307.6(of)-311.5(accuracy)-314.3(will)-310.6(be)-311.3(sufcient,)-311(while)-314.8(others)-310.8(will)]TJ 0 -1.2203 TD [(seek)-231.7(to)-224.3(maximize)-227.1(precision.)-223.9(Sharpening)-226.5(the)-226.3(assessment)-229.7(takes)-228.9(some)]TJ T* [(effort,)-387.3(including)-376.8(the)-384.3(data-quality)-380.5(management)-382.6(steps)-385.7(already)-383.5(out-)]TJ 0 -1.2266 TD [(lined.)-308.1(There)-302(will)-304.3(nonetheless)-303.2(be)-298.6(limits)-308.7(to)-300.2(how)-299(accurate)-305.7(an)-304.9(assess-)]TJ 0 -1.2203 TD [(ment)-248.3(based)-250.2(predominantly)-244.3(on)-251.9(patient)-247.4(and)-241.2(collateral)-251.1(reports)-249.7(can)-250(be.)]TJ /F3 1 Tf -27.9978 77.2217 TD (2444)Tj 47.093 0 TD [(WILSON)-336.9(ET)-338.7(AL.)]TJ ET endstream endobj 92 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 69.7323 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(In)-191.3(principle,)-188.7(it)-184.1(is)-187.6(possible)-192.3(to)-186.4(extend)-189.3(the)-188.3(rigor)-183.8(of)-191.3(the)-188.3(assessment)-191.7(by)]TJ -1.1128 -1.2203 TD [(using)-344.2(the)-346.4(GOSE)-344.5(as)-344.1(a)-343.4(framework)-343.9(within)-347.6(which)-342.4(other)-348(assessments)]TJ 0 -1.2266 TD [(can)-186.7(contribute)-191.7(greater)-190.1(condence)-187.2(in)-186.4(the)-188.3(nal)-186.4(rating.)-183.8(For)-189.4(example,)-185(in)]TJ 0 -1.2203 TD [(the)-498.2(province)-500.7(of)-494.8(Ontario,)-496.4(Canada,)-498.8(the)-498.2(GOSE)-502.6(is)-491.1(used)-501.2(to)-496.2(dene)]TJ T* [()54.8(catastrophic)-268.4(impairment)52.1()-267.7(after)-264.5(TBI)-264.9(for)-263(no-fault)-264.7(compensation.)]TJ 6.7246 0 0 5.9768 292.1385 685.9274 Tm (22)Tj 8.9663 0 0 8.9663 59.7543 670.9604 Tm [(As)-250.1(codied)-250.6(in)-243.3(legislation,)-251.3(a)-248.5(rating)-250.4(of)-248.2(Upper)-246.2(SD)-247.5(or)-248.2(less)-247.1(at)-252.1(6)-246.1(months)]TJ T* [(or)-400(Lower)-391.4(MD)-401.4(or)-393.6(less)-392.6(at)-397.5(12)-397.4(months)-391.5(are)-398(considered)-395.9(to)-395.1(be)-399.8()54.8(cata-)]TJ T* [(strophic.)54.2()-267.7(That)-257.2(is,)-266.4(these)-260.5(indicate)-268.3(long-lasting,)-259.6(life-changing)-264.8(levels)]TJ 0 -1.2266 TD [(of)-482.2(disability.)-483.3(Clearly,)-481.3(the)-485.5(award)-482.5(of)-482.2(compensation)-482.1(is)-478.4(not)-483.1(based)]TJ 0 -1.2203 TD [(simply)-313.3(on)-315.2(interviewing)-311.8(the)-314.8(patient,)-313.6(no)-308.8(matter)-319.6(how)-311.7(skillful)-313.1(the)-308.5(as-)]TJ T* [(sessor.)-267.8(In)-260.9(these)-260.5(cases,)-269.3(a)-261.2(wide)-260.7(variety)-265(of)-260.9(information)-264.4(is)-263.5(collected)-263.9(in)]TJ T* [(evidence,)-215(and)-203.3(medico-legal)-211.7(expertise)-210.7(has)-204.5(been)-211.5(developed)-209.2(locally)-203.2(in)]TJ 0 -1.2266 TD [(using)-325.2(the)-321.1(GOSE)-325.5(as)-325.1(a)-324.4(framework)-324.9(for)-319.9(deciding)-325.1(eligibility)-322.4(for)-326.2(com-)]TJ 0 -1.2203 TD (pensation.)Tj 6.7246 0 0 5.9768 96.4913 587.2817 Tm (23)Tj 8.9663 0 0 8.9663 104.8819 583.3132 Tm [(Such)-195.1(an)-184.8(exhaustive)-195(process)-189.8(is)-193.9(impractical)-190.9(in)-186.4(the)-194.7(setting)]TJ -5.033 -1.2203 TD [(of)-349.4(a)-349.7(multi-center)-348.7(study,)-347.1(but)-350.3(it)-342.2(serves)-354.6(to)-344.5(suggest)-346.8(possible)-350.4(ways)-346.4(in)]TJ 0 -1.2266 TD [(which)-355.1(global)-355.3(outcome)-356.7(assessment)-356.1(could)-358.1(be)-349.2(rened)-357.2(by)-353.1(additional)]TJ 0 -1.2203 TD (assessments.)Tj 1.1128 -1.2203 TD [(At)-221.3(the)-213.6(other)-221.6(end)-215.9(of)-216.6(the)-219.9(spectrum,)-217.5(the)-220(GOSE)-218(can)-218.3(be)-216.4(assessed)-223.1(by)-214(a)]TJ -1.1128 -1.2266 TD [(questionnaire)-351.9(that)-349.9(is)-345.7(completed)-349.5(by)-346.8(the)-346.4(patient)-348.6(or)-343.1(a)-349.7(caregiver)-349.6(and)]TJ 0 -1.2203 TD [(then)-200.5(scored)-195.4(centrally.)-197.5(This)-199.1(approach)-195.6(has)-198.1(been)-192.6(used)-197.7(in)-199.1(several)-195(recent)]TJ T* [(clinical)-291.3(studies)]TJ 6.7246 0 0 5.9768 113.8393 510.5762 Tm [(24)-9.1(26)]TJ 8.9663 0 0 8.9663 133.2283 506.6077 Tm [(and)-285.5(is)-288.8(particularly)-281.9(useful)-285.5(in)-287.6(situations)-281.6(such)-286.2(as)]TJ -8.1945 -1.2203 TD [(surgical)-385.8(treatment)-387.8(trials,)-385(where)-381.4(blinding)-381.2(of)-387.3(assessors)-382(is)-383.6(difcult.)]TJ 0 -1.2266 TD [(Interviewing)-234.5(is)-225.5(thus)-230.9(not)-230.2(essential)-232.3(to)-230.7(the)-226.3(assessment,)-232.6(although,)-230.8(done)]TJ 0 -1.2203 TD [(well,)-286.6(should)-280.5(lend)-276.4(extra)-280.9(precision)-284.2(and)-279.2(robustness.)]TJ 1.1128 -1.2203 TD [(The)-234.7(Manual)-240.6(describes)-233.2(circumstances)-243.6(in)-237(which)-234.9(the)-232.6(GOSE)-237(can)-237.3(be)]TJ -1.1128 -1.2266 TD [(applied)-262.4(to)-256(patients)-254.4(who)-254.8(are)-258.9(in)-256(the)-257.9(hospital,)-255(but)-255.5(some)-258.1(aspects)-256.8(of)-260.9(the)]TJ 0 -1.2203 TD [(scale)-262.9(are)-265.2(only)-261.3(relevant)-260.6(if)-258.6(patients)-260.8(have)-262.1(returned)-263.1(to)-262.3(the)-257.9(community.)]TJ T* [(Nonetheless,)-454.8(potentially)-449.5(useful)-443.6(information)-454.1(concerning)-445.3(function)]TJ 0 -1.2266 TD [(can)-199.4(be)-203.8(collected)-200.7(before)-203.1(discharge)-200.4(from)-196.5(the)-201(hospital)-201.5(in)-192.7(a)-204.3(manner)-197.7(that)]TJ 0 -1.2203 TD [(parallels)-410.7(the)-409.6(GOSE.)]TJ 6.7246 0 0 5.9768 134.1921 411.9306 Tm (27)Tj 8.9663 0 0 8.9663 144.5669 407.9621 Tm [(The)-411.8(information)-409.9(may)-402.8(contribute)-413(to)-407.7(better)]TJ -9.4591 -1.2203 TD [(prediction)-286.5(of)-279.8(outcome)-280.9(on)-277.2(the)-283.2(GOSE.)]TJ /F10 1 Tf 0 -3.0603 TD [(Clinimetric)-341.5(properties)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-316.9(GOSE)-312.9(is)-314.1(an)-317.6(ordinal)-313.1(scale)-319.8(consisting)-315.5(of)-311.4(a)-318.1(hierarchy)-315.6(of)-317.8(dis-)]TJ -1.1128 -1.2203 TD [(crete)-447.7(categories,)-449.5(and)-443.6(each)-447.9(of)-444.2(the)-447.6(steps)-442.7(from)-443.1(death)-449(to)-445.6(complete)]TJ T* [(recovery)-248.8(\(return)-251.1(to)-249.6(pre-injury)-247.3(life\))-247.2(is)-244.5(multi-dimensional)-252.8(and)-247.5(global)]TJ 0 -1.2266 TD [(in)-287.6(nature.)-289.7(Thus,)-286.5(there)-287.2(is)-288.8(not)-280.8(a)-286.5(latent)-292.2(unidimensional)-284.4(ability)-287(under-)]TJ 0 -1.2203 TD [(lying)-328.1(all)-325.1(states)-328.5(described)-326.8(by)-327.8(the)-327.4(scale.)-329.1(For)-322.2(example,)-330.5(although)-329(the)]TJ T* [(construct)-258.9(of)-248.2(disability)-252.8(runs)-254.8(through)-249.8(much)-250.6(of)-254.5(the)-251.6(GOSE,)-252.6(it)-253.7(does)-248.3(not)]TJ 0 -1.2267 TD [(apply)-408.7(to)-407.7(lower)-414.6(parts)-406.1(of)-406.3(the)-409.6(scale)-408.4(such)-412.6(as)-407.3(death)-411.1(versus)-409.1(survival.)]TJ 0 -1.2203 TD (Feinstein)Tj 6.7246 0 0 5.9768 92.7496 280.4031 Tm (28)Tj 8.9663 0 0 8.9663 102.3874 276.4345 Tm [(describes)-328(similar)-328.2(types)-327.7(of)-330.4(scales,)-329.8(including)-326.2(the)-327.4(Apgar)]TJ -4.7548 -1.2203 TD [(assessment)-368.8(of)-368.4(infant)-364.2(health)-364(and)-361.4(indices)-371.1(of)-362(socioeconomic)-370.2(status,)]TJ T* [(that)-457.4(are)-454.9(composites)-456.5(of)-456.9(selected)-457.6(indicators.)-455(The)-456(Glasgow)-453.4(Coma)]TJ 0 -1.2266 TD (Scale)Tj 6.7246 0 0 5.9768 79.3134 247.5779 Tm (29)Tj 8.9663 0 0 8.9663 88.5543 243.5527 Tm [(is)-276.1(another)-286.3(example)-283.3(of)-279.8(such)-279.9(a)-280.1(scale.)]TJ -2.0992 -1.2203 TD -.0152 Tc [(Ke)-15.2(y)-389.7(r)1.7(e)-15.2(q)15(uire)-15.2(m)11.4(e)1.8(nts)-401.6(a)-15.2(r)12.4(e)-402.8(th)4.3(a)-15.2(t)-387.4(the)-402.8(GOSE)-400.2(s)-15.2(h)16.2(ould)-400.4(h)-2.1(ave)-396.5(v)-2.1(al)-15.2(u)13.4(e)-402.8(in)-400.4(de-)]TJ -1.1128 -1.2203 TD -.0147 Tc [(s)-14.7(c)14.3(r)-14.7(i)11.3(bin)4.8(g)-355.6(cli)-14.7(n)13.9(ic)-14.7(a)13.1(lly)-355.6(importa)-14.7(n)15.5(t)-353.3(pheno)4.8(m)-14.7(e)11.9(na)-351.7(and)-355.6(t).7(h)4.8(a)-14.7(t)-342.6(i).7(t)-353.3(c)2.3(a)-14.7(n)-338.6(be)-351.7(a)-14.7(p)15.5(plie)-14.7(d)]TJ 0 -1.2266 TD 0 Tc [(co)23.9(n)19.5(s)0(i)27.4(s)18.3(te)26.2(n)13.1(t)15.4(l)15.4(y)-391.5(b)19.5(y)-391.5(as)29(se)29(ss)30.2(o)13.1(r)16.9(s.)-376.7(It)-378.7(i)15.4(s)-392.7(n)19.5(o)13.1(t)-389.2(n)13.1(e)17(c)0(e)27.8(s)0(s)30.2(a)0(r)27.6(y)-391.5(t)15.4(h)13.1(a)17(t)-389.2(i)15.4(t)0(e)26.2(m)15.9(s)-392.7(s)18.3(h)13.1(o)13.1(u)19.5(ld)-376.1(b)13.1(e)]TJ 0 -1.2203 TD -.0155 Tc [(c)-15.5(o)8.4(rre)-15.5(l)10.7(a)1.5(te)-15.5(d)14.7(.)-536.9(For)-536.1(e)-15.5(x)14.7(a)-15.5(m)11.1(p)-2.4(le,)-536.9(p)-2.4(art)-15.5(i)9.1(cipati)-15.5(o)13.1(n)-539.8(in)-533.5(wor)-15.5(k)-523(and)-533.5(p)-2.4(a)-15.5(r)12.1(tic)-15.5(i)10.7(p)4(a)-15.5(t)10.6(ion)]TJ T* -.0152 Tc [(in)-476.3(s)-15.2(o)9.9(cia)-15.2(l)-463.3(a)-15.2(n)15(d)-476.3(l).2(e)-15.2(i)11(s)-15.2(u)16.2(r)-15.2(e)-461.8(a)-15.2(c)12.6(tivitie)-15.2(s)-466.8(n)-2.1(eed)-476.3(not)-474(be)-478.7(pos)-15.2(i)12.2(tively)-476.3(c)-15.2(o)15(r)-15.2(r)12.2(e)-15.2(l)11(a)1.8(te)-15.2(d)15(.)]TJ 0 -1.2266 TD -.0148 Tc [(N)-14.8(o)14.5(ne)-14.8(t)11.4(h)4.7(e)-14.8(l)11.4(es)-14.8(s)15.4(,)-308.6(th)4.7(e)-14.8(r)12.8(e)-307.6(a)2.2(re)-307.6(expec)-14.8(t)11.4(ations)-300(of)-301.4(logica)-14.8(l)-292.1(r)2.1(e)-14.8(l)11.4(ations)3.5(hips)-300(be)-14.8(t)11.4(w)1.4(ee)-14.8(n)]TJ 0 -1.2203 TD -.0156 Tc [(dif)-15.6(f)11.8(er)-15.6(e)12(n)-2.5(t)-360.6(p)-2.5(ar)-15.6(t)10.4(s)-357.7(of)-365.5(the)-365.3(a)1.4(s)-15.6(s)8.3(es)-15.6(s)14.6(m).3(e)-15.6(n)8.3(t.)-360(For)-359.2(e)-15.6(x)14.6(a)-15.6(m)11(p)-2.5(le,)-360(a)-15.6(s)-353.3(d)3.9(e)-15.6(s)13.4(c)-15.6(r)12(ibed)-362.9(in)-362.9(the)]TJ T* 0 Tc [(M)12.4(a)17(n)13.1(u)13.1(a)17(l)15.4(,)-224.2(i)15.4(t)-224.8(i)15.4(s)-222(i)15.4(n)19.5(co)23.9(n)19.5(s)0(i)27.4(s)18.3(te)26.2(n)13.1(t)-218.5(fo)30(r)-223.4(s)18.3(o)13.1(m)15.9(eo)30.2(n)13.1(e)-223.2(w)16.2(h)13.1(o)-220.8(r)16.9(ep)23.9(o)19.5(r)0(t)26(s)-222(t)15.4(h)19.5(at)-207.8(t)15.4(h)13.1(ey)-210.1(a)17(r)16.9(e)-223.2(b)13.1(a)17(c)0(k)]TJ T* [(at)-416.4(wo)29.3(rk)-418.9(t)15.4(o)-429.5(a)17(l)15.4(so)-417.5(r)16.9(e)0(p)30.2(o)13.1(r)16.9(t)-433.5(t)15.4(h)13.1(a)17(t)-427.2(th)28.6(ey)-418.8(a)17(r)0(e)-415(d)13.1(e)17(p)13.1(en)30.2(d)13.1(e)17(n)13.1(t)-433.5(i)15.4(n)-429.5(d)19.5(a)0(i)26.1(l)15.4(y)-429.5(l)15.4(i)15.4(f)0(e)27.6(.)-432.9(T)19.6(h)13.1(e)]TJ 0 -1.2266 TD [(as)29(se)29(ss)23.9(o)19.5(r)-267.7(i)15.4(s)-266.3(e)17(x)13.1(p)13.1(e)17(ct)26.2(e)17(d)-265.1(t)15.4(o)-265.1(i)15.4(d)13.1(e)17(n)13.1(t)15.4(i)15.4(f)0(y)-254.5(a)17(n)13.1(d)-265.1(r)16.9(e)0(c)27.8(o)13.1(n)19.5(c)0(i)26.2(l)15.4(e)-267.5(s)18.3(u)13.1(c)0(h)-254.4(i)15.4(n)19.5(c)0(o)23.9(n)19.5(si)27.4(s)18.3(t)0(e)26.2(n)13.1(c)17(i)15.4(es)29(.)]TJ 1.1128 -1.2203 TD [(Participation)-262.5(is)-250.8(assessed)-261(in)-256(relation)-255.9(to)-256(pre-injury)-260(status,)-259.4(and)-253.9(this)]TJ -1.1128 -1.2203 TD [(means)-304.3(that)-299.4(some)-302.4(aspects)-307.4(of)-298.8(the)-302.1(assessment)-305.5(reect)-300.4(relative)-302.5(change)]TJ 0 -1.2266 TD [(for)-332.5(the)-327.4(person.)-328.7(For)-328.5(example,)-330.5(someone)-328.6(with)-331.9(high)-324.5(pre-injury)-329.5(voca-)]TJ 0 -1.2203 TD [(tional)-289.8(demands)-290.7(may)-289(nd)-288(reintegration)-287.8(more)-291.1(difcult)-290(than)-289(the)-289.5(per-)]TJ T* [(son)-322.2(with)-325.5(less)-323(exacting)-321.2(work.)-323(Similarly,)-318.9(patients)-324(who)-324.3(were)-324.9(retired)]TJ 0 -1.2266 TD [(before)-260(injury)-260.6(may)-257.4(nd)-256.4(it)-260(easier)-258.7(to)-256(return)-261.6(to)-256(their)-257.2(normal)-262.6(social)-257.7(and)]TJ 0 -1.2203 TD [(leisure)-202.9(activities)-207(and)-203.3(may)-200.5(consequently)-200.3(show)-204.9(better)-202.2(recovery)-204.6(than)-200.5(a)]TJ 28.0042 74.5598 TD [(younger)-279.8(person)-287.8(who)-280(was)-283.7(engaged)-288.4(in)-281.3(full-time)-288.4(work)-282.2(before)-285.3(injury.)]TJ 0 -1.2203 TD [(These)-357.5(relationships)-354.7(have)-357(been)-357(described)-358.4(in)-350.8(mild)-357.4(TBI)-353.4(by)-359.4(van)-355(der)]TJ 0 -1.2266 TD [(Naalt)-285.6(and)-279.2(colleagues,)]TJ 6.7246 0 0 5.9768 388.6298 707.8676 Tm (30)Tj 8.9663 0 0 8.9663 397.9274 703.8423 Tm [(who)-280(showed)-288.5(that)-280.4(in)-287.6(more)-278.5(highly)-283.3(educated)]TJ -9.712 -1.2203 TD [(persons,)-354.7(there)-363.1(may)-358.6(be)-355.5(a)-362.3(U-shaped)-355.8(relationship)-360.3(between)-358.9(outcome)]TJ T* [(and)-430.9(aging.)-436.9(The)-437(principle)-432.4(here)-435.4(is)-440.5(that)-432.1(return)-438.7(to)-433(normal)-433.3(life)-434.7(will)]TJ 0 -1.2266 TD [(depend,)-302(in)-300.2(part,)-300.9(on)-296.2(how)-305.3(demanding)-298.9(participation)-301.8(in)-300.2(activities)-308.2(was)]TJ 0 -1.2203 TD [(before)-361.2(injury.)-358.4(The)-361.2(GOSE)-357.1(differs)-359.8(in)-363.4(this)-355(respect)-365.7(from)-354.5(health)-364(out-)]TJ T* [(comes,)-307.2(such)-298.8(as)-306.1(for)-307.2(example,)-305.2(the)-302.2(36-Item)-308.9(Short)-299.9(Form)-306.3(Survey,)-300.8(that)]TJ 0 -1.2266 TD [(are)-277.9(norm)-282.4(based.)]TJ /F10 1 Tf 0 -2.7505 TD [(Approaches)-335.4(to)-330.4(analysis)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(In)-412.6(clinical)-411.4(trials)-420(the)-409.6(GOS)-414.7(and)-411.9(GOSE)-414(are)-417(often)-417.6(dichotomized)]TJ -1.1128 -1.2203 TD [(in)-388.7(analysis)-397(into)-391.8()54.8(favorable)53.2()-394.1(and)-393()54.8(unfavorable)54.2()-394.1(outcomes.)-398.3(This)]TJ T* [(yields)-350.2(a)-349.7(clear)-352.9(interpretation)-354.5(of)-349.4(ndings,)-344.7(but)-350.3(can)-351.1(be)-349.2(criticized)-358.6(be-)]TJ T* [(cause)-322.1(it)-316.9(reduces)-323.8(the)-321.1(scales)-320.5(to)-319.2(two)-322(outcomes.)-322.4(Ordinal)-316.5(analysis)-321.2(has)]TJ 0 -1.2266 TD [(been)-293.7(shown)-292.9(to)-300.2(have)-293.7(greater)-297.6(statistical)-300.3(power)-296.7(than)-295.3(simple)-296.8(dichoto-)]TJ 0 -1.2203 TD (mization)Tj 6.7246 0 0 5.9768 342.4251 546.1794 Tm (31,32)Tj 8.9663 0 0 8.9663 361.2471 542.2109 Tm [(and)-411.9(therefore)-413(is)-415.2(preferred)-411.6(for)-414.7(many)-415(purposes.)-411.1(Ad-)]TJ -5.6211 -1.2203 TD [(justment)-293.5(for)-294.6(baseline)-297.1(covariates)-294.8(can)-294.2(also)-296.5(improve)-293.7(power)-296.7(to)-293.9(detect)]TJ 0 -1.2266 TD [(effects)-273.5(on)-270.9(the)-270.5(GOS)-269.3(and)-272.8(GOSE,)-271.5(and)-272.8(there)-268.3(is)-269.8(an)-273.3(extensive)-271.3(literature)]TJ 0 -1.2203 TD [(on)-403.7(TBI)-404(outcome)-407.3(prediction)-406.6(that)-406.9(can)-401.7(inform)-408.2(selection)-408.1(of)-406.3(covari-)]TJ T* (ates.)Tj 6.7246 0 0 5.9768 327.0613 502.3558 Tm (33)Tj 8.9663 0 0 8.9663 337.0393 498.3873 Tm [(Cumulative)-361.7(link)-353.8(models,)-358.9(and)-361.4(specically)-357.6(the)-359.1(proportional)]TJ -2.9212 -1.2266 TD [(odds)-207.9(model,)-212.8(a)-210.6(form)-215.4(of)-210.3(ordinal)-212(logistic)-211.8(regression,)-216.8(have)-211.5(been)-211.5(widely)]TJ 0 -1.2203 TD [(used)-343.1(in)-344.5(work)-351.7(on)-340.5(TBI)-347.1(prognosis.)-349(Other)-345(ordinal)-344.8(analysis)-352.8(strategies)]TJ T* [(include)-584.8(the)-586.7(sliding)-585.2(approach)-587.7(to)-584.7(dichotomization)-592.6(proposed)-584(by)]TJ T* [(Murray)-511.2(and)-513.1(colleagues.)]TJ 6.7246 0 0 5.9768 400.1385 458.5322 Tm (34)Tj 8.9663 0 0 8.9663 411.4203 454.5637 Tm [(For)-511.9(a)-514.1(sliding)-509.3(dichotomy,)-512(the)-510.8(binary)]TJ -11.2168 -1.2266 TD [(outcome)-280.9(is)-282.4(tailored)-281.2(to)-281.3(the)-276.9(baseline)-284.5(prognosis)-282.8(of)-279.8(the)-276.9(person.)]TJ 1.1128 -1.2203 TD 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[(dichotomization.)-235.1(This)-237(latter)-244.2(approach)-233.6(to)-237(analysis)-239(is)-238.2(consistent)-242(with)]TJ T* [(conceptualizing)-507.7(the)-510.8(GOSE)-508.9(as)-508.5(consisting)-505.2(of)-507.5(discrete)-508.4(categories)]TJ 0 -1.2266 TD [(which)-253.9(may)-257.4(have)-262.1(their)-257.2(own)-254.8(specic)-260.5(associations)-257.3(with)-262.3(other)-253.2(factors.)]TJ /F3 1 Tf 0 -2.7505 TD (Conclusion)Tj /F4 1 Tf 1.1128 -1.8336 TD [(The)-253.7(GOSE)-249.6(has)-255.1(become)-260.8(the)-251.6(most)-253.4(frequently)-253.5(adopted)-258.4(measure)-257.7(of)]TJ -1.1128 -1.2203 TD [(global)-216.2(outcome)-217.6(in)-218(TBI)-220.6(clinical)-221.8(trials)-217.7(and)-215.9(research)-220.8(studies.)-221(It)-220.6(is)-212.9(used)]TJ T* [(internationally)-222.7(and)-215.9(is)-225.5(the)-220(preferred)-221.9(primary)-220.4(outcome)-217.6(of)-222.9(efcacy)-222.4(for)]TJ T* [(FDA-regulated)-373.4(drug)-367.4(and)-367.7(device)-375.1(trials.)-372.3(Maximizing)-370.3(the)-371.7(ability)-369.2(to)]TJ 0 -1.2267 TD [(assign)-214.5(GOSE)-211.7(scores)-215.5(uniformly)-214.7(within)-208.4(and)-215.9(across)-215.5(single-)-213.2(and)-215.9(multi-)]TJ 0 -1.2203 TD [(center)-244.9(studies)-243.4(is)-244.5(thus)-243.5(of)-248.2(key)-241.2(importance.)-247.1(We)-250(hope)-240.7(that)-248.8(this)-241.2(Manual)]TJ T* [(for)-395.8(the)-390.7(GOSE,)-398(aimed)-395.6(at)-397.5(assessors,)-391.3(will)-399.1(contribute)-394(to)-395.1(facilitating)]TJ 0 -1.2267 TD [(agreement)-281(and)-279.2(support)-282.6(the)-283.2(ongoing)-278.8(use)-280.3(of)-279.8(the)-283.2(scale.)]TJ /F3 1 Tf 0 -2.4406 TD [(Funding)-334.6(Information)]TJ /F4 1 Tf 1.1128 -1.8336 TD .0138 Tc [(The)-241(a)-.8(uth)-4.7(o)1.6(rs)-239.8(ackn)-4.7(o)1.6(wled)-4.7(ge)-234.7(s)-5.9(u)1.6(p)-4.7(port)-236.3(f)-1(r)-7.3(o)1.6(m)-235.8(t)-2.4(he)-234.7(f)-7.3(o)1.6(llowing)-238.6(so)-4.7(urce)-7.1(s:)]TJ -1.1128 -1.2266 TD .0156 Tc [(European)-439.2(Union)-445.5(7)3.4(th)-439.2(Framewor)]TJ 13.4235 0 TD .0153 Tc [(k)-439.5(p)-3.2(rogram)-443(\(CENTER-TBI,)-442.9(EC)]TJ -13.4235 -1.2203 TD .0138 Tc [(gran)-4.7(t)-400.7(6)1.6(0)-4.7(2)1.7(1)-4.7(50\),)-400.1(H)-1.7(a)-7.1(n)1.6(ne)-7.1(lo)-4.7(re)-399.1(Ko)-4.7(hl)-400.7(Stiftu)-4.7(ng)-403(\(Germany)-4.7(\),)-400.1(One)-7.1(M).9(ind)]TJ T* .0143 Tc [(and)-269.7(I)-.5(ntegra)-272.2(Lif)-6.8(e)-.3(Sc)-6.6(ie)-6.6(nces)-270.9(Cor)-6.8(pora)-6.6(t)-1.9(ion;)-273.8(United)-269.7(S)3.6(tate)-6.6(s)-264.6(D)-1.2(oDTBI)]TJ T* -.0153 Tc [(Endpoints)-464.9(De)-15.3(v)14.9(e)-15.3(l)10.9(o)4.2(pme)-15.3(n)14.9(t)-467.8(I)1.6(nitiati)]TJ 12.6676 0 TD [(v)13.2(e)-466.3(\(Gr)-15.4(a)12.2(nt)-461.5(#W81X)-15.4(W)12(H)-15.4(-)11.3(14-)-15.4(2)14.6(-)-15.4(0)14.6(176\))-15.4(,)]TJ -12.6676 -1.2266 TD -.0148 Tc 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[(Scie)-15.5(n)14.7(t)-15.5(i)9.1()-.9(c)-238.7(A).7(dvisory)-242.6(BoardTRACK-)-15.5(T)14.7(B)-15.5(I)-230.5(L)-2.2(ONGI)-15.5(T)8.3(UDIN)-15.5(A)10.5(L)-242.4(\()1.4(Gr)-15.5(a)12.1(n)-2.4(t)]TJ T* -.0151 Tc [(#)4.4(1317)4.4(69A\);)-246.3(Unite)-15.1(d)-231.5(S)-.5(ta)-15.1(t)11.1(e)1.9(s)-249.7(D)1.1(e)-15.1(p)15.1(a)-15.1(r)12.5(tme)-15.1(n)15.1(t)-246.3(o)-2(f)-244.8(E)-1.8(ner)-15.1(g)14.9(y)-248.6(p)-2(rec)-15.1(i)11(s)3.2(i)-15.1(o)13.5(n)-248.6(medic)-15.1(i)11.1(n)4.4(e)]TJ 0 -1.2266 TD .0184 Tc [(collaboration;)-370.8(addition)6.2(al)-377.2(su)6.2(pport)-370.8(f)-2.7(rom)-376.7(N)2.9(FL)-379.3(an)6.2(d)-379.5(N)2.9(euroTrauma)]TJ 0 -1.2203 TD .0186 Tc [(Scie)4(nces)-279.3(LLC.)]TJ /F3 1 Tf -28.0042 77.228 TD 0 Tc [(MANUAL)-341(FOR)-334(THE)-335.2(GOSE)-330.7(INTERVIEW)]TJ 52.4612 0 TD (2445)Tj ET endstream endobj 97 0 obj <>stream /GS1 gs BT /F3 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(Author)-338.7(Disclosure)-330.4(Statement)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(No)-280.5(competing)-277.6(nancial)-288.2(interests)-283(exist.)]TJ /F3 1 Tf -1.1128 -2.6683 TD (References)Tj /F4 1 Tf 7.9702 0 0 7.9702 65.9905 670.5069 Tm [(1.)-494.8(Jennett,)-273.5(B.,)-270.9(and)-267.3(Bond,)-265.7(M.)-273.4(\(1975\).)-263.6(Assessment)-265.2(of)-269.5(outcome)-264.2(after)-271.6(severe)]TJ 1.2448 -1.131 TD [(brain)-329(damage.)-326.8(A)-334.7(practical)-327.3(scale.)-332.2(Lancet)-329.8(305,)-327(480484)14.5(.)]TJ -1.2448 -1.1239 TD [(2.)-494.8(Rankin,)-270.3(J.)-282.6(\(1957\).)-263.6(Cerebral)-273.3(vascular)-273.5(accidents)-269.7(in)-278.9(patients)-271(over)-275.7(the)-272.9(age)]TJ 1.2448 -1.1239 TD [(of)-333.6(60:)-333.7(II.)-328.8(Prognosis.)-323.7(Scott.)-328(Med.)-329.4(J.)-332.4(2,)-331.2(200215)14.5(.)]TJ -1.2448 -1.1239 TD [(3.)-494.8(Karnofsky,)-477.7(D.,)-474.9(Abelmann,)-477(W.,)-473.6(and)-480.7(Craver,)-481(L.)-480.4(\(1948\).)-469.9(The)-480.5(use)-481.9(of)]TJ 1.2448 -1.1239 TD [(nitrogen)-321.3(mustards)-321.6(in)-321.5(the)-329.8(palliativ)12.7(e)-328.3(treatment)-320.5(of)-326.4(carcinoma.)-318.6(Cancer)-318.2(1,)]TJ T* (634656.)Tj -1.2448 -1.1239 TD [(4.)-494.8(Maas,)-395.7(A.I.R.,)-384.3(Menon,)-389.2(D.K.,)-389(Adelson,)-388.1(P.D.,)-391.4(et)-395.9(al.)-394.8(\(2017\).)-384.5(Traumatic)]TJ 1.2448 -1.131 TD [(brain)-485.5(injury:)-482.2(integrated)-485.6(approaches)-473.2(to)-492.3(improve)-477.8(prevention,)-475.8(clinical)]TJ 0 -1.1239 TD [(care,)-330.9(and)-331.3(research.)-330.4(Lancet)-329.8(Neurol.)-328.4(16,)-329.1(987104)14.5(8.)]TJ -1.2448 -1.1239 TD [(5.)-494.8(Jennett,)-323.3(B.,)-327.8(Snoek,)-323.9(J.,)-324.2(Bond,)-322.6(M.R.,)-323.8(and)-324.2(Brooks,)-323(N.)-326.6(\(1981\).)-320.5(Disability)]TJ 1.2448 -1.1239 TD [(after)-513.5(severe)-506.8(head)-503.1(injury:)-503.6(observations)-496.4(on)-508(the)-507.6(use)-510.3(of)-511.4(the)-507.6(Glasgow)]TJ T* [(Outcome)-330.7(Scale.)-328.8(J.)-332.4(Neurol.)-328.4(Neurosurg)12.1(.)-333.3(Psychiatry)-319.3(44,)-336.2(285293)14.5(.)]TJ -1.2448 -1.1239 TD [(6.)-494.8(Maas,)-274.8(A.I.R.,)-263.4(Braakman,)-266.8(R.,)-270.9(Schouten)13.9(,)-276.4(H.J.A.,)-266.1(Minderho)12.4(ud,)-272.2(J.M.,)-270.4(and)]TJ 1.2448 -1.131 TD [(van)-494.9(Zomeren,)-481.3(A.H.)-489.6(\(1983\).)-491.2(Agreemen)11.8(t)-494.3(between)-486.9(physicians)-482.9(on)-493.8(as-)]TJ 0 -1.1239 TD [(sessment)-336.8(of)-340.7(outcome)-328.2(following)-331.2(severe)-343.2(head)-332.4(injury.)-335.4(J.)-339.5(Neurosurg)12.1(.)-340.4(58,)]TJ T* (321325.)Tj -1.2448 -1.1239 TD [(7.)-494.8(Anderson,)-398.1(S.I.,)-406.5(Housley,)-395.3(A.M.,)-399.8(Jones,)-406.7(P.A.,)-398.5(Slattery,)-398(J.,)-409.6(and)-402.4(Miller,)]TJ 1.2448 -1.1239 TD [(J.D.)-353.1(\(1993\).)-341.8(Glasgow)-349(Outcome)-344.9(Scale:)-347.6(an)-347.6(inter-rater)-344.4(reliability)-347.8(study.)]TJ T* [(Brain)-333.7(Inj.)-328.9(7,)-331.2(309317.)]TJ -1.2448 -1.1239 TD [(8.)-494.8(Wilson,)-355.7(J.T.L.,)-353.2(Pettigrew,)-355.7(L.E.L.,)-358.9(and)-352.6(Teasdale,)-357.4(G.M.)-358.2(\(1998\).)-348.9(Struc-)]TJ 1.2448 -1.131 TD [(tured)-627.8(interviews)-621.3(for)-626.5(the)-628.5(Glasgow)-626.4(Outcome)-622.4(Scale)-628.6(and)-622.9(Extended)]TJ 0 -1.1239 TD [(Glasgow)-299.2(Outcome)-302.3(Scale:)-297.8(guidelines)-295.3(for)-306.4(their)-299.1(use.)-303(J.)-303.9(Neurotrau)11.6(ma)-301.3(15,)]TJ T* (573585.)Tj -1.2448 -1.1239 TD [(9.)-494.8(Bagiella,)-383.4(E.,)-386.9(Novack,)-379.5(T.A.,)-386.3(Ansel,)-385.2(B.,)-384.7(et)-388.8(al.)-387.7(\(2010\).)-377.4(Measuring)-381.1(out-)]TJ 1.2448 -1.1239 TD [(come)-243.5(in)-236.2(traumatic)-235.2(brain)-236.6(injury)-236.9(treatment)-235.2(trials:)-236.2(recommenda)11.7(tions)-243.9(from)]TJ T* [(the)-351.1(Traumatic)-336.1(Brain)-348(Injury)-341.4(Clinical)-337(Trials)-347.8(Network)11.5(.)-347.5(J)0(.)-346.6(Head)-349.2(Trauma)]TJ 0 -1.131 TD [(Rehabil.)-326.8(25,)-329.1(375382.)]TJ -1.7427 -1.1239 TD -.0164 Tc [(1)-16.4(0)-16.4(.)-509.1(Wi)-16.4(l)12.1(d)-.1(e,)-342.6(E.A.,)-335.5(W)-1.2(hit)-16.4(e)14.5(ne)-16.4(c)9.8(k)-.1(,)-335.5(G)-2.6(.G.,)-335.4(B)-16.4(o)18.6(gne)-16.4(r)9.6(,)-335.5(J.,)-342.6(e)-16.4(t)-326.9(a)3.8(l)-16.4(.)-324.7(\()-16.4(2)12.8(010\).)-342.6(R)2.3(e)-16.4(c)9.8(omm)-16.4(e)16.6(nda)-16.4(-)]TJ 1.7427 -1.1239 TD 0 Tc [(ti)28.5(o)16.3(n)16.3(s)-255.2(f)20(o)16.3(r)-257.4(t)17.8(h)16.3(e)-250.1(u)16.3(s)15.1(e)-257.2(o)23.4(f)-257.4(c)20.2(o)16.3(m)0(m)32.7(o)16.3(n)-254(o)16.3(u)16.3(t)17.8(co)29.4(m)19.9(e)-257.2(m)19.9(e)0(a)33.3(s)15.1(u)16.3(r)0(e)26(s)-248.1(in)-236.2(tr)30.7(au)29.4(m)19.9(a)0(t)30.9(i)0(c)-239.4(b)16.3(ra)33.1(in)-236.2(in)27(j)17.8(u)16.3(ry)]TJ T* -.017 Tc [(r)-17(e)9(sea)-17(r)9(ch.)-336(A)-3.2(rc)-17(h)12.4(.)-336.1(Phys.)-336.1(M).2(e)-17(d)19.5(.)-336.1(R)-17(e)14.8(h)-.7(a)-17(b)12.4(il)-17(.)-318.2(91,)-336.1(16501660.)]TJ -1.7427 -1.1239 TD 0 Tc [(11.)-492.7(Maas,)-331.7(A.I.,)-332.9(Menon,)-325.2(D.K.,)-332.1(Steyerberg,)-325.2(E.W.,)-328(et)-339(al.)-330.8(\(2015\).)-327.6(Collabora-)]TJ 1.7427 -1.1239 TD [(tive)-560.9(Europea)12(n)-559.9(NeuroTrauma)-547.1(Effectiveness)-546.6(Research)-553.2(in)-556.3(Traumatic)]TJ T* [(Brain)-255.5(Injury)-248.9(\(CENTER-)12.7(TBI\):)-255.5(a)-250.1(prospective)-244.4(longitudinal)-248.1(observatio)12.8(nal)]TJ 0 -1.131 TD [(study.)-329.7(Neurosurg)12.1(ery)-334.7(76,)-329.1(6780.)]TJ -1.7427 -1.1239 TD [(12.)-492.7(Yue,)-403.9(J.K.,)-401.9(Vassar,)-399.5(M.J.,)-398.5(Lingsma,)-403.2(H.F.,)-398.5(et)-403(al.)-402(\(2013\).)-398.7(Transformi)11.5(ng)]TJ 1.7427 -1.1239 TD [(research)-345.6(and)-338.4(clinical)-342.6(knowledg)12.4(e)-349.7(i)0(n)-342.9(traumatic)-334.8(brain)-343.2(injury)-336.5(pilot:)-344.3(mul-)]TJ T* [(ticenter)-397.3(implementat)12.2(ion)-397.7(of)-397.6(the)-400.9(common)-389(data)-402(elements)-393(for)-398.9(traumat)11.3(ic)]TJ T* [(brain)-329(injury.)-328.3(J.)-332.4(Neurotrauma)-325.3(30,)-329.1(183118)14.5(44.)]TJ -1.7427 -1.1239 TD [(13.)-492.7(Boase,)-520.2(K.,)-517.6(Machame)13.3(r,)-519.5(J.,)-516.3(Temkin,)-517.9(N.R.,)-512.1(Dikmen,)-513.5(S.,)-512.9(Wilson,)-512.2(L.,)]TJ 1.7427 -1.131 TD [(Barber,)-431.2(J.,)-438(Bodien,)-426.8(Y.G.,)-431.6(Giacino,)-424.2(J.T.,)-434.7(McCrea,)-430.1(M.,)-428.9(Nelson,)-432.9(L.D.,)]TJ 0 -1.1239 TD [(Satris,)-337.6(G.,)-339.8(Stein,)-335.1(M.B.,)-330.9(Taylor,)-332.8(S.)-343.2(and)-331.3(Manley,)-339.1(G.)-333.7(\(In)-342(press\).)-333.2(Central)]TJ T* [(curation)-516.5(of)-525.6(GOSE)-520.7(data:)-519.4(lessons)-517.1(from)-514.2(TRACK-TBI,)-518(a)-520.4(multicenter)]TJ T* [(observational)-324.1(traumatic)-327.6(brain)-329(injury)-329.3(study.)-322.6(J)-333.4(Neurotrauma.)]TJ -1.7427 -1.1239 TD [(14.)-492.7(Giacino,)-331.8(J.T.,)-328(Kalmar,)-328(K.,)-332.7(and)-331.3(Whyte,)-325.7(J.)-339.5(\(2004\).)-320.5(The)-338.2(JFK)-329.6(Coma)-330.3(Re-)]TJ 1.7427 -1.1239 TD [(covery)-559.3(Scale-Revi)12.2(sed:)-556.5(Measurement)-550.5(characteris)9(tics)-562.1(and)-551.8(diagnostic)]TJ 0 -1.131 TD [(utility.)-332.5(Arch.)-327(Phys.)-323.9(Med.)-329.4(Rehabil.)-326.8(85,)-329.1(20202029.)]TJ -1.7427 -1.1239 TD [(15.)-492.7(Giacino,)-267.7(J.T.,)-264(Katz,)-268.4(D.I.,)-268.9(Schiff,)-270.2(N.D.,)-260.9(et)-275(al.)-266.8(\(2018\).)-263.6(Practice)-264.7(guideline)]TJ 1.7427 -1.1239 TD [(update)-433.5(recommen)10.8(dations)-427.8(summary:)-430.6(disorders)-426.1(of)-433.1(conscious)11.4(ness:)-434.7(Re-)]TJ T* [(port)-342.1(of)-340.7(the)-344(Guideline)-341.4(Develo)12.2(pment,)-342.3(Disseminat)10.5(ion,)-339.8(and)-345.5(Implement)12(a-)]TJ T* [(tion)-557.7(Subcomm)13.6(ittee)-560.5(of)-554.1(the)-557.4(American)-548.6(Academy)-555.9(of)-554.1(Neurology;)-547.3(the)]TJ T* [(American)-342.4(Congress)-331.4(of)-340.7(Rehabilitation)-331.9(Medicine;)-334.1(and)-338.4(the)-344(National)-336.3(In-)]TJ T* [(stitute)-239.9(on)-244.8(Disability,)-233.6(Independe)12.8(nt)-243.3(Living,)-239.4(and)-238.8(Rehabilitation)-232.3(Research.)]TJ 0 -1.131 TD [(Neurology)-323.2(91,)-329.1(450460.)]TJ -1.7427 -1.1239 TD [(16.)-492.7(Kondziella,)-512.2(D.,)-510.5(Bender,)-513.2(A.,)-510.5(Diserens,)-507.7(K.,)-517.6(et)-516.8(al.)-508.6(\(2020\).)-512.5(European)]TJ 1.7427 -1.1239 TD [(Academy)-307(of)-305.1(Neurology)-301.9(guideline)-303.3(on)-301.7(the)-308.4(diagnosis)-304(of)-305.1(coma)-307.5(and)-310(other)]TJ T* [(disorders)-326.5(of)-333.6(conscious)11.4(ness.)-330.6(Eur.)-330.3(J.)-332.4(Neurol.)-328.4(27,)-329.1(741756)14.5(.)]TJ -1.7427 -1.1239 TD [(17.)-492.7(Ercole,)-328.9(A.,)-325.6(Brinck,)-323.5(V.,)-332.7(Huijben,)-321.4(J.,)-331.4(et)-324.7(al.)-330.8(\(2020\).)-320.5(Guidelines)-326.2(for)-327.8(Data)]TJ 1.7427 -1.1239 TD [(Acquisition,)-339.7(Quality)-335.2(&)-342.9(Curation)-340.2(for)-342(Observat)11.7(ional)-338.3(Research)-339.8(Designs)]TJ 0 -1.131 TD [(\(DAQCORD\).)-322(J.)-332.4(Clin.)-333.8(Transl.)-326.9(Sci.)-326.5(4,)-331.2(354359.)]TJ -1.7427 -1.1239 TD [(18.)-492.7(Choi,)-292.6(S.C.,)-294(Clifton,)-293.9(G.L.,)-293.8(and)-288.6(Marmarou,)-289.8(A.)-298.1(\(2002\).)-292(Misclass)10.5(ication)]TJ 1.7427 -1.1239 TD [(and)-281.5(treatment)-277.8(effect)-279.9(on)-280.4(primary)-274.9(outcome)-278.4(measur)12.2(es)-284.8(in)-278.9(clinical)-278.6(trials)-282.4(of)]TJ T* [(severe)-328.9(neurotrauma.)-321.7(J.)-332.4(Neurotrauma)-325.3(19,)-329.1(1722.)]TJ -1.7427 -1.1239 TD [(19.)-492.7(Horton,)-268.3(L.,)-273.1(Rhodes,)-265.9(J.,)-274.4(and)-274.4(Wilson,)-270.3(L.)-267(\(2018\).)-270.7(Randomized)-265.9(controlled)]TJ 1.7427 -1.1239 TD [(trials)-360.7(in)-364.2(adult)-359.7(traumatic)-356.1(brain)-357.5(injury:)-361.3(a)-363.9(systemati)10.9(c)-363.9(review)-361.1(on)-358.6(the)-365.3(use)]TJ 31.5041 78.9842 TD [(and)-452.2(reporting)-457.8(of)-454.5(clinical)-456.4(outcome)-449.1(assessments.)-456.1(J.)-453.3(Neurotrauma)-453.3(35,)]TJ 0 -1.1239 TD [(200520)14.5(14.)]TJ -1.7498 -1.1239 TD [(20.)-499.8(Wilson,)-398.4(J.T.L.,)-403(Slieker,)-401.6(F.J.A.,)-403.7(Legrand,)-399.5(V.,)-403.8(Murray,)-401.1(G.,)-403.8(Stocchetti,)]TJ 1.7498 -1.131 TD [(N.,)-325.6(and)-331.3(Maas,)-331.7(A.I.R.)-328.5(\(2007\).)-320.5(Observer)-327.5(variation)-328(in)-328.7(the)-329.8(assessment)-322.8(of)]TJ 0 -1.1239 TD [(outcome)-484.7(in)-492.3(traumatic)-491.2(brain)-492.6(injury:)-482.2(experience)-488(from)-492.8(a)-491.9(multicenter,)]TJ T* [(internation)12(al)-331.9(randomized)-321.5(clinical)-328.4(trial.)-332.1(Neurosurge)11(ry)-333.6(61,)-329.1(123128.)]TJ -1.7498 -1.1239 TD [(21.)-499.8(Nelson,)-269.3(L.D.,)-279.6(Temkin,)-276.1(N.R.,)-270.2(Dikmen,)-278.8(S.,)-278.2(et)-275(al.)-281(\(2019\).)-270.7(Recovery)-278.5(after)]TJ 1.7498 -1.1239 TD [(mild)-269.6(traumat)11.3(ic)-275(brain)-272.1(injury)-265.3(in)-271.7(patients)-263.9(presenting)-264.6(to)-271.7(US)-273.6(level)-270.4(I)-271.6(trauma)]TJ T* [(centers:)-407.1(a)-413.7(Transformi)11.5(ng)-408.4(Research)-411(and)-409.5(Clinical)-408.2(Knowledge)-403.8(in)-414(Trau-)]TJ T* [(matic)-430.4(Brain)-433.3(Injury)-433.8(\(TRACK-T)10(BI\))-439.2(study.)-429.3(JAMA)-430.9(Neurol.)-435.1(76,)-435.8(1049)]TJ 0 -1.131 TD (1059.)Tj -1.7498 -1.1239 TD [(22.)-499.8(MacDon)11.5(ald,)-513.7(D.F.)-513.3(\(2016\).)-512.5(Catastrophi)11.7(c)-520.4(denitio)13(n)-517.2(changes)-508.4(for)-519.8(auto)]TJ 1.7498 -1.1239 TD [(accidents)-447.5(on)-451.1(or)-454.5(after)-449.4(June)-451.3(1,)-452.1(2016.)-445.9(Thomson)-445.2(Rogers:)-444.6(North)-449.2(York,)]TJ T* -.0168 Tc [(Ont)-16.8(a)14.1(r)-16.8(i)13.9(o.)-855.1(ht)-16.8(t)11.7(p)-.5(s:/)-16.8(/)11.7(www)11.2(.)-1.5(thomsonr)-16.8(o)12.4(g)-.5(e)-16.8(r)16.3(s)12.5(.)-1.5(c)-16.8(o)12.6(m/wp-)-16.8(c)16.3(ont)-16.8(e)14.1(n)-.5(t)-16.8(/)11.7(uploa)-16.8(d)12.6(s)-1.7(/2016/02/)]TJ T* 0 Tc [(20)-10.1(1)-12.1(6)0(-)-13.5(0)0(2)-10.1(-)-8.4(2)-12.1(5)0(-)-13.5(C)0(A)-10.2(T)-12(-)-8.4(d)0(e)-13.3()0(n)-15(i)0(t)-14.2(i)-10.6(on)-10.1(s-)-14.7(c)-8.2(h)-12.1(a)-8.2(n)0(g)-10.1(e)-8.2(s-)-14.7(f)-8.4(o)0(r)-13.5(-)-8.4(a)-8.2(u)0(t)-15.7(o)0(-)-13.5(a)-8.2(c)-8.2(c)-8.3(i)-10.6(d)0(e)-13.3(n)0(t)-15.7(s)0(-)-14.7(o)0(n)-17.2(-)-8.4(or)-13.5(-)-8.4(a)-8.2(f)-8.4(t)0(e)-11.8(r)-8.4(-)]TJ T* .0088 Tc [(j)8.8(u)-6.9(n)8.8(e)-4.5(-1)8.8(-)-4.7(2)8.8(0)-8.4(1)8.8(6.)-11.5(p)8.8(d)-1.3(f)-334(\().4(L)8.8(a)-4.3(s)8.8(t)-342.4(acces)8.8(sed)-330.5(M)-2.5(arch)-330.6(2)8.8(9)-1.3(,)-331.6(2)-3.3(0)8.8(2)-1.3(1)8.8(\))-4.7(.)]TJ -1.7498 -1.131 TD 0 Tc [(23.)-499.8(MacDon)11.5(ald,)-243.4(D.F.)-243(\(2019\).)-235.1(Using)-240.8(medically)-238.9(recognized)-235.8(brain)-243.7(diagnostic)]TJ 1.7498 -1.1239 TD [(technology,)-451(GOSE)-463.8(and)-466.4(clinician)-454.4(documentation)-458.2(to)-463.8(determi)11.3(ne)-468.5(brain)]TJ T* [(inj)16.4(ur)15(y)-275.3(a)0(n)15.2(d)-275.3(cat)15.6(as)14(tro)18.6(phi)14.9(c)-271.4(imp)18.4(air)15.4(men)20.8(t.)-272.8(Ome)18.3(ga)-269.3(Me)16.1(dic)18.8(al)-275(As)14.7(soc)16.1(iat)20.3(es:)-267(No)15.9(rth)]TJ T* [(Yo)15.9(rk,)-702.4(On)15.9(tar)15.4(io.)-704.6(htt)16.4(ps)17.2(://w)17.5(ww)13.4(.)15.3(tho)14.9(ms)13.7(onr)17.1(oge)17.3(rs)13.8(.c)14.1(om)14.9(/wp)19.5(-co)13.9(nte)18.8(nt/)16.4(up)18.4(load)20.8(s/)]TJ T* -.0175 Tc [(2019/11/)-17.5(D)14.1(e)-17.5(t)13.4(e)-17.5(r)8.5(m)2.4(ini)-17.5(n)9.5(g-B)-17.5(r)14.1(a)-17.5(i)6.3(n-I)-17.5(n)11.7(jur)-17.5(y)11.7(-a)-17.5(n)11.9(d)-1.2(-)-17.5(C)14.1(a)-17.5(t)13.4(a)-17.5(s)10.7(tr)-17.5(o)11.7(phic)-17.5(-)8.5(Im)-17.5(p)11.6(a)2.7(i)-17.5(r)13.2(m)-17.5(e)8.4(nt-)-17.5(D)16.3(a)-17.5(v)11.9(id-)]TJ T* -.0168 Tc [(Ma)-16.8(c)16.5(D)-3(ona)-16.8(l)14.1(d)13.7(.pdf)-331.1(\()-16.8(L)12.6(a)-16.8(s)11.4(t)-333.3(a)-16.8(c)16.5(c)-16.8(e)9.4(ssed)-334.8(M).4(a)-16.8(r)9.2(ch)-334.8(29,)-335.9(2021\))-16.8(.)]TJ -1.7498 -1.1239 TD 0 Tc [(24.)-499.8(Andrews,)-601.8(P.J.,)-603.4(Sinclair,)-604.3(H.L.,)-606.8(Rodriguez,)-605(A.,)-603(et)-616.4(al.)-608.2(\(2015\).)-597.9(Hy-)]TJ 1.7498 -1.131 TD [(pothermia)-240.6(for)-249.5(intracranial)-244.7(hypertensi)12.8(on)-251.9(after)-243.2(traumatic)-249.4(brain)-243.7(injury.)-242.9(N.)]TJ 0 -1.1239 TD [(Engl.)-323.3(J.)-332.4(Med.)-329.4(373,)-327(24032412.)]TJ -1.7498 -1.1239 TD [(25.)-499.8(Hutchins)12.7(on,)-350.5(P.J.,)-347.4(Kolias,)-346(A.G.,)-346.3(Timofeev,)-342.5(I.S.,)-349.6(et)-346.1(al.)-352.2(\(2016\).)-341.8(Trial)-348.7(of)]TJ 1.7498 -1.1239 TD [(decompressi)12.5(ve)-240.9(craniectomy)-235.7(for)-242.4(traumat)11.3(ic)-246.5(intracra)10.3(nial)-240.8(hypertension.)-231(N.)]TJ T* [(Engl.)-323.3(J.)-332.4(Med.)-329.4(375,)-327(11191130.)]TJ -1.7498 -1.1239 TD [(26.)-499.8(Mendelow,)-415.7(A.D.,)-424.5(Gregson,)-421.5(B.A.,)-426.7(Rowan,)-425.8(E.N.,)-421.8(et)-431.4(al.)-430.4(\(2015\).)-420.1(Early)]TJ 1.7498 -1.131 TD [(surgery)-252.7(versus)-245.5(initial)-258.5(conservativ)11.7(e)-257.2(treatment)-249.4(in)-257.5(patients)-249.6(with)-254.4(traumatic)]TJ 0 -1.1239 TD .0144 Tc [(intracer)6(ebral)-373.2(h)2.3(emorr)6(h)-4.9(age)-370.8(\()-1.1(S)4.5(T)2.4(ITCH[Traum)5.8(a]\):)-373.2(the)-378()4.5(rst)-373.2(r)6(andomized)]TJ T* .0125 Tc [(tri)-5.3(a)-2.9(l.)-335(J.)-335(Neurot)-5.3(rau)-6.8(m)3.9(a)-337.2(32,)-335(1)-6.8(3121)-6.8(323.)]TJ -1.7498 -1.1239 TD 0 Tc [(27.)-499.8(McMillan,)-323.9(T.M.,)-326(Weir,)-331.2(C.J.,)-333(Ireland,)-323.3(A.,)-332.7(and)-331.3(Stewart,)-325.8(E.)-331(\(2013\).)-327.6(The)]TJ 1.7498 -1.1239 TD [(Glasgow)-505.5(Outcome)-501.4(at)-509.7(Discharge)-508.7(Scale:)-504.1(an)-511.2(inpatient)-508.1(assessment)-500.7(of)]TJ T* [(disability)-324.6(after)-328.5(brain)-329(injury.)-328.3(J.)-332.4(Neurotrau)11.6(ma)-329.8(30,)-336.2(970974)14.5(.)]TJ -1.7498 -1.1239 TD [(28.)-499.8(Feinstein,)-336.8(A.R.)-349.5(\(1983\).)-341.8(An)-339.8(additional)-342.4(basic)-344.2(science)-346.5(for)-349.1(clinical)-342.6(med-)]TJ 1.7498 -1.131 TD [(icine:)-466(IV.)-470.2(The)-473.4(developm)15.3(ent)-472(of)-468.7(clinimetrics.)-467.9(Ann.)-464.7(Intern.)-464.5(Med.)-471.6(99,)]TJ 0 -1.1239 TD [(843848)14.5(.)]TJ -1.7498 -1.1239 TD [(29.)-499.8(Teasdale,)-428.6(G.,)-432.3(Maas,)-431.3(A.,)-439.4(Lecky,)-428.7(F.,)-434.7(Manley,)-431.5(G.,)-432.3(Stocchetti)12.3(,)-440(N.,)-432.3(and)]TJ 1.7498 -1.1239 TD [(Murray,)-244.6(G.)-248.3(\(2014\).)-242.2(The)-245.7(Glasgow)-242.3(Coma)-245(Scale)-251.6(at)-246.5(40)-244.8(years:)-246(standing)-247.9(the)]TJ T* [(test)-327.4(of)-333.6(time.)-328.7(Lancet)-329.8(Neurol.)-328.4(13,)-329.1(844854)14.5(.)]TJ -1.7498 -1.1239 TD [(30.)-499.8(van)-338.4(der)-334.7(Naalt,)-335.9(J.,)-338.5(Timmerma)12.2(n,)-338.3(M.E.,)-340.2(de)-333.4(Koning,)-336(M.E.,)-333.1(et)-339(al.)-337.9(\(2017\).)]TJ 1.7498 -1.131 TD [(Early)-435.5(predictors)-431.6(of)-440.3(outcome)-427.8(after)-442.3(mild)-433.2(traumatic)-434.3(brain)-435.7(injury)-428.9(\(UP-)]TJ 0 -1.1239 TD [(FRONT\):)-286.3(an)-290.7(observatio)12.8(nal)-294.2(cohort)-284.3(study.)-287(Lancet)-287.1(Neurol.)-285.7(16,)-286.4(532540.)]TJ -1.7498 -1.1239 TD [(31.)-499.8(Roozenbeek)10.3(,)-418.6(B.,)-420.2(Lingsma,)-417.4(H.F.,)-412.7(Perel,)-421.5(P.,)-413.3(et)-424.3(al.)-423.3(\(2011\).)-413(The)-416.5(added)]TJ 1.7498 -1.1239 TD 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