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1 Tf 8.9343 0 TD [(Data)-307.4(were)-299.6(analyzed)-307(in)-300.2(R)-301.4(version)-304(3.6.1.)]TJ 6.7246 0 0 5.9768 294.4062 713.3101 Tm (19)Tj 8.9663 0 0 8.9663 62.022 699.3636 Tm [(The)-260(outcome)-261.9(was)-264.7(modeled)-261.9(as)-261.9()54.8(logit)-258.3(of)-260.9(patients)-267.1(lost)-260.2(to)-262.3(follow-up)55.3()]TJ 0 -1.1065 TD [(\(i.e.,)-206(the)-201(log)-204.9(odds)-207.9(of)-197.6(patient)-209.5(attrition)-204.1(by)-201.4(the)-207.3(end)-203.3(of)-204(the)-207.3(study\))-200.9(using)-205.1(a)]TJ 0 -1.1128 TD [(logistic)-313(regression)-315.1(model.)-314(The)-310.6(rationale)-314.7(for)-313.6(modeling)-313.6(proportions)]TJ T* [(in)-192.7(that)-191.9(manner)-197.7(has)-191.8(been)-192.6(described)-200.4(elsewhere.)]TJ 6.7246 0 0 5.9768 221.4991 673.455 Tm (20)Tj 8.9663 0 0 8.9663 230.0031 669.4865 Tm [(Notably,)-190.3(it)-196.7(accounts)]TJ -18.7348 -1.1128 TD 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-1.1128 TD [(number)-220.6(of)-216.6(degrees)-222.6(of)-216.6(freedom)-225.1(with)-218(a)-216.9(cut-off)-219.5(of)-216.6(two)-220.8(\(analogous)-222.7(to)-218(a)]TJ T* [(conventional)-291.7(variance-ination)-295.5(factor)-289.3(of)-292.5(four\),)]TJ 6.7246 0 0 5.9768 231.0802 583.8235 Tm (21)Tj 8.9663 0 0 8.9663 240.3779 579.7983 Tm [(none)-291.3(of)-292.5(the)-289.5(vari-)]TJ -19.8919 -1.1065 TD [(ables)-412.3(raised)-408.1(concern)-411.1(for)-402.1(multi-collinearity.)-415.3(Missing)-406(values)-411.8(were)]TJ 0 -1.1128 TD [(imputed)-301.4(using)-306.3(multiple)-302.7(imputation)-308(\(see)-303.8(below\))-300.3(to)-306.5(allow)-302.2(inclusion)]TJ T* [(of)-425.3(all)-426.3(148)-422.2(studies.)-423.3(Model)-422(t)-425.3(was)-422.8(assessed)-431.7(using)-420.1(the)-428.6(McFadden)]TJ 0 -1.1065 TD [(Pseudo-R-squared)-348.1(on)-340.5(each)-346.7(of)-343.1(the)-346.4(20)-340.5(imputed)-345.7(datasets.)-345.5(Statistical)]TJ 0 -1.1128 TD [(signicance)-227.1(was)-220.4(determined)-225.2(by)-220.3(95%)-222(condence)-218.8(intervals)-225(\(CIs\).)-222.9(As)]TJ T* [(a)-324.4(sensitivity)-329.3(analysis,)-324.1(the)-327.4(model)-323.7(was)-327.9(repeated)-328.5(using)-325.2(only)-324.5(the)-321.1(104)]TJ T* [(studies)-281.3(with)-281.3(complete)-280.5(reporting.)]TJ /F2 1 Tf 29.1107 24.0587 TD [(Multiple)-243.3(imputation.)]TJ /F4 1 Tf 9.5413 0 TD -.0131 Tc [(T)-13.1(h)7(e)-192.1(m)2.8(a)-13.1(j)6.7(or)-13.1(i)6.5(t)-13.1(y)-180.5(o)0(f)-192.3(s)-13.1(t)8(udi)-13.1(e)6.7(s)-190.8(ha)-13.1(d)-178.9(s)-13.1(o)5.7(m)2.8(e)-192.1(m)-13.1(i)5.6(s)-13.1(s)10.8(i)-13.1(n)9.1(g)]TJ -10.6541 -1.1128 TD 0 Tc [(da)17.5(ta)-416.5(be)17.5(ca)21.4(u)13.1(s)0(e)-419.9(o)13.1(f)-432.1(i)0(n)22.2(c)0(o)17.5(m)15.9(pl)22.2(et)19.8(e)-431.9(r)0(e)21.2(p)13.1(or)17.3(t)15.4(i)0(n)22.2(g)0(.)-419.7(O)0(f)-422.2(1)13.1(4)13.1(8)-429.5(st)21.1(ud)19.9(ie)19.8(s,)-414.6(da)17.5(t)15.4(a)-431.9(we)20.5(re)]TJ T* [(co)17.5(mp)22.7(le)19.8(t)15.4(e)-286.5(f)16.9(o)0(r)-273.5(3)13.1(3)-277.7(s)0(t)21.1(u)0(d)19.9(i)0(e)19.8(s)0(.)-269.2(A)0(l)25.3(l)-281.7(o)13.1(t)0(h)22.3(e)0(r)-269.6(s)0(t)21.1(u)0(d)20(i)0(e)19.8(s)-278.9(we)20.5(re)-269.6(mi)25(ss)17.6(i)15.4(n)0(g)-270.9(a)0(t)-271(l)15.4(ea)15.1(st)-269.8(o)13.1(n)13.1(e)]TJ 0 -1.1065 TD [(va)17.5(lu)22.2(e)-292.8(\()0(m)20.1(a)0(x)23.9(i)0(m)18.7(u)13.1(m)-293.9()0(v)21.4(e)-292.8(v)13.1(a)0(l)19.8(u)0(e)17.5(s)-291.5(mi)18.7(ss)23.9(in)22.2(g)-290.4(p)0(e)17.5(r)-293(st)21.1(u)13.1(d)0(y)20(\))-293(wi)18.9(t)15.4(h)-296.7(a)-292.8(t)0(o)22.2(t)0(a)19.8(l)-294.4(o)13.1(f)-293(19)20(1)]TJ 0 -1.1128 TD [(mi)18.7(ss)23.9(in)22.2(g)-442.1(v)13.1(al)19.8(u)13.1(e)0(s)-426.3(\()0(s)22.5(e)0(e)-433.8(R)14.7(es)22.7(ul)22.2(ts)21.1(\).)-428.7(We)-427(ha)17.5(n)13.1(d)13.1(l)0(e)19.8(d)-435.8(mi)18.7(ss)23.9(in)22.2(g)-435.8(d)0(a)17.5(t)0(a)-429.1(a)0(s)-426.3(p)13.1(er)-427.7(a)]TJ T* [(pr)17.3(ev)23.9(io)22.2(u)13.1(s)0(l)21.1(y)-227.1(pu)19.9(b)13.1(l)0(i)18.2(s)0(h)25.1(e)0(d)-216.4(f)0(r)21.1(a)0(m)20.3(e)0(w)20.5(o)13.1(rk)17.3(.)]TJ 6.7246 0 0 5.9768 428.9384 679.9746 Tm (8)Tj 8.9663 0 0 8.9663 434.381 675.9495 Tm [(A)-224.1(c)0(o)17.5(m)0(p)22.7(a)0(r)21.2(i)0(s)21.1(o)13.1(n)-227.1(o)13.1(f)-229.7(s)0(t)21.1(u)13.1(di)22.2(es)-217.6(wi)18.9(th)-218(an)23.9(d)]TJ -13.531 -1.1065 TD [(wi)18.9(th)22.2(o)13.1(u)0(t)-344.5(c)0(o)17.5(m)15.9(pl)15.9(et)26.2(e)-356(r)0(e)21.2(p)0(o)19.9(r)0(t)19.6(i)15.4(ng)-346.8(su)25.1(gg)19.9(es)22.7(te)19.8(d)-353.6(n)13.1(o)-359.9(e)0(v)23.9(i)0(d)22.3(e)0(n)23.9(c)0(e)-345.3(a)0(g)17.5(a)0(i)19.8(n)13.1(st)-345.7(t)15.4(h)0(e)-349.2(h)13.1(y)13.1(-)]TJ 0 -1.1128 TD [(po)19.9(th)22.2(es)22.7(is)-446.8(th)22.3(at)-441.7(da)17.5(t)15.4(a)-457.2(o)13.1(n)-454.8(d)13.1(e)0(s)16.3(i)15.4(gn)-448(fa)21.2(ct)26.2(or)17.3(s)-449.6(w)0(e)20.5(r)0(e)-446.7(m)0(i)18.7(s)0(s)23.9(i)0(n)22.2(g)-454.8(co)23.8(mp)22.7(le)19.8(te)19.8(ly)-439.3(at)]TJ T* -.0139 Tc [(r)-13.9(a)1(ndom)-377.3(\()-13.9(L)9.9(i)-13.9(t)4.3(tl)-13.9(e)-367.1(M)-1.5(C)-13.9(A)10.7(R)-378.5(t)1.5(e)-13.9(s)2.4(t)]TJ /F9 1 Tf 11.1663 0 TD 0 Tc (p)Tj /F7 1 Tf .6576 0 TD (=)Tj /F4 1 Tf .7082 0 TD -.0146 Tc [(0.)-14.6(7)8.3(4)-1.5(,)-377.9(p)-1.5(a)-14.6(c)6.8(ka)-14.6(ge)-370.6(B)-14.6(a)4.5(yl)-14.6(o)7.6(r)-14.6(EdP)-14.6(s)5.6(yc)-14.6(h)-363.8(0)-1.5(.)-14.6(5)1.9(\).)]TJ -12.532 -1.1128 TD 0 Tc [(Th)20.1(er)21.2(e)-216.9(w)0(e)20.5(r)0(e)-200.1(n)0(o)-201.4(r)0(e)21.2(d)-214.5(a)18.9(g)13.1(s)-215.7(su)25.1(gg)19.9(es)22.7(ti)18.2(n)13.1(g)-214.5(d)13.1(a)0(t)19.8(a)-210.6(we)20.5(re)-206.4(mi)25(ss)17.6(in)22.3(g)-214.5(n)13.1(o)13.1(t)-212.2(at)-207.8(ra)21.2(n)13.1(d)13.1(o)0(m)16.4(.)]TJ 1.1128 -1.1065 TD [(We)-294.2(used)-292.5(multiple)-290(imputation)-295.4(to)-293.9(create)-291.6(and)-291.8(analyze)-294.8(20)-289.9(imputed)]TJ -1.1128 -1.1128 TD [(datasets)-285.6(\(package)-280.3(mice)-276(3.1.0\).)-281.3(Incomplete)-282.1(variables)-280.3(were)-280.7(imputed)]TJ T* [(using)-198.8(the)-188.3(package)-195.9(default)-195.4(settings,)-199.2(with)-192.8(the)-194.7(exception)-194.3(of)-191.3(continuous)]TJ T* [(variables)-362.5(for)-357.8(which)-361.4(we)-358.8(used)-355.7(predictive)-358.5(mean)-360.5(matching)-360.3(with)-357.2(dis-)]TJ 0 -1.1065 TD [(tance)-483(aided)-474.3(selection)-477.7(of)-482.2(donors.)-471.7(Adequacy)-480.9(of)-475.8(imputations)-479.4(was)]TJ 0 -1.1128 TD [(conrmed)-252.2(by)-245.6(the)-245.2(presence)-249.8(of)-248.2(convergence)-249.6(and)-247.5(plausibility)-243.2(on)-245.6(strip)]TJ T* [(and)-285.5(density)-280.1(plots.)]TJ /F1 1 Tf 0 -3.2816 TD (Results)Tj /F4 1 Tf 1.1128 -1.8336 TD [(A)-344.3(total)-347.1(of)-343.1(148)-346.3(studies)-344.5(from)-348.2(the)-346.4(original)-342(195)-346.3(TBI)-347.1(studies)-344.5(were)]TJ -1.1128 -1.2203 TD [(included)-186(\(Fig.)-183.2(1\).)-181.6(Studies)-183.9(followed)-189.5(patients)-184.9(for)-180.8(a)-185.3(median)-186.5(duration)-179.9(of)]TJ ET 0 0 0 .025 k 62.022 399.685 224.334 9.9779 re f 305.575 399.685 78.916 9.9779 re f 403.767 399.685 79.313 9.9779 re f 502.299 399.685 49.89 9.9779 re f 62.022 379.786 224.334 9.9213 re f 305.575 379.786 78.916 9.9213 re f 403.767 379.786 79.313 9.9213 re f 502.299 379.786 49.89 9.9213 re f 62.022 359.83 224.334 9.978 re f 305.575 359.83 78.916 9.978 re f 403.767 359.83 79.313 9.978 re f 502.299 359.83 49.89 9.978 re f 62.022 339.931 224.334 9.9212 re f 305.575 339.931 78.916 9.9212 re f 403.767 339.931 79.313 9.9212 re f 502.299 339.931 49.89 9.9212 re f 62.022 319.975 224.334 9.978 re f 305.575 319.975 78.916 9.978 re f 403.767 319.975 79.313 9.978 re f 502.299 319.975 49.89 9.978 re f 62.022 300.075 224.334 9.978 re f 305.575 300.075 78.916 9.978 re f 403.767 300.075 79.313 9.978 re f 502.299 300.075 49.89 9.978 re f 62.022 280.12 224.334 9.9779 re f 305.575 280.12 78.916 9.9779 re f 403.767 280.12 79.313 9.9779 re f 502.299 280.12 49.89 9.9779 re f 62.022 260.22 224.334 9.978 re f 305.575 260.22 78.916 9.978 re f 403.767 260.22 79.313 9.978 re f 502.299 260.22 49.89 9.978 re f 62.022 240.264 224.334 9.9779 re f 305.575 240.264 78.916 9.9779 re f 403.767 240.264 79.313 9.9779 re f 502.299 240.264 49.89 9.9779 re f 62.022 220.365 224.334 9.9779 re f 305.575 220.365 78.916 9.9779 re f 403.767 220.365 79.313 9.9779 re f 502.299 220.365 49.89 9.9779 re f 62.022 200.466 224.334 9.9213 re f 305.575 200.466 78.916 9.9213 re f 403.767 200.466 79.313 9.9213 re f 502.299 200.466 49.89 9.9213 re f 62.022 180.51 224.334 9.9779 re f 305.575 180.51 78.916 9.9779 re f 403.767 180.51 79.313 9.9779 re f 502.299 180.51 49.89 9.9779 re f 62.022 160.611 224.334 9.9213 re f 305.575 160.611 78.916 9.9213 re f 403.767 160.611 79.313 9.9213 re f 502.299 160.611 49.89 9.9213 re f 62.022 140.655 224.334 9.978 re f 305.575 140.655 78.916 9.978 re f 403.767 140.655 79.313 9.978 re f 502.299 140.655 49.89 9.978 re f 62.022 120.756 224.334 9.9213 re f 305.575 120.756 78.916 9.9213 re f 403.767 120.756 79.313 9.9213 re f 502.299 120.756 49.89 9.9213 re f 62.022 100.8 224.334 9.978 re f 305.575 100.8 78.916 9.978 re f 403.767 100.8 79.313 9.978 re f 502.299 100.8 49.89 9.978 re f 0 0 0 rg 62.022 471.515 490.167 .28348 re f 62.022 87.024 490.167 .22675 re f 305.575 442.205 246.614 .22675 re f 62.022 414.425 490.167 .28348 re f BT /F6 1 Tf 8.9663 0 0 8.9663 212.8818 477.1841 Tm (Table)Tj /F4 1 Tf 2.9971 0 TD (1.)Tj /F6 1 Tf 1.2519 0 TD [(Characteristics)-333.6(of)-335.1(Included)-336.9(Studies)]TJ /F9 1 Tf 6.089 -3.4397 TD [(Interventional)-336.4(studies)-2152.9(Observational)-338.7(studies)]TJ 21.9405 1.1065 TD [(Design)-336.8(factor)]TJ .2529 -1.1065 TD [(not)-331.4(reported)]TJ -49.3566 -2.8327 TD [(Design)-336.8(factor)]TJ 28.6491 1.1128 TD [(Median)-334.4([IQR])]TJ -.7524 -1.1128 TD [(or)-329(Frequency)-341.4(\(%\))]TJ 11.7227 1.1128 TD [(Median)-334.4([IQR])]TJ -.7524 -1.1128 TD [(or)-329(Frequency)-341.4(\(%\))]TJ 10.9007 1.1128 TD [(Percent)-337.6(of)]TJ -.1897 -1.1128 TD [(148)-333.7(studies)]TJ -49.5779 -2.0929 TD (n)Tj /F4 1 Tf 31.0645 0 TD [(18)-9723.7(130)]TJ -31.0645 -1.1128 TD [(Percentage)-341.2(attrition)-330.6(by)-334.1(end)-336.1(of)-330.4(study)-15323.2(6)-328.3([2,)-333.3(9])-7386.8(12)-334.1([4,)-333.3(29])-6810.9(10)]TJ 0 -1.1065 TD [(Number)-337.7(of)-330.4(patients)-336.6(initially)-338.3(enrolled)-13523.6(336)-333.6([170,)-332.4(403])-4888.3(292)-333.6([160,)-332.4(687])-5811.4(10)]TJ 0 -1.1128 TD [(Study)-335.3(duration)-331.6(\(months\))-20072.6(6)-328.3([4,)-333.3(6])-7639.7(6)-334.6([6,)-333.3(12])-7557(0)]TJ T* [(Number)-337.7(of)-330.4(follow-up)-334.6(time)-334.5(points)-16395.3(1)-328.3([1,)-333.3(2])-7892.6(1)-328.3([1,)-333.3(2])-7810.4(0)]TJ T* [(Male)-336.4(sex)-25546.7(77)-334.1([71,)-332.8(83\))-6387.3(75)-334.1([71,)-332.8(80])-7057.5(5)]TJ 0 -1.1065 TD [(Age)-27610.1(38)-334.1([34,)-332.8(43])-6387.3(40)-334.1([35,)-332.8(46])-7057.5(3)]TJ 0 -1.1128 TD [(Injury)-335.1(severity)-335.2(based)-332.4(on)-334.1(GCS)]TJ 51.8858 0 TD (1)Tj -50.8868 -1.1128 TD [(Mixed)-26706.4(5)-328.3(\(28\))-8223(57)-334.1(\(44\))]TJ T* [(Mild)-27372.3(0)-328.3(\(0\))-9222.5(7)-334.6(\(5\))]TJ 0 -1.1065 TD [(Moderate)-339.5(to)-331.8(severe)-21468.1(6)-328.3(\(33\))-8223(22)-334.1(\(17\))]TJ 0 -1.1128 TD [(Severe)-334.3(only)-24478.1(7)-328.3(\(39\))-8223(43)-334.1(\(33\))]TJ -.999 -1.1128 TD [(Military)-334(population)-22405.4(0)-328.3(\(0\))-9222.5(2)-334.6(\(2\))-8350(0)]TJ 0 -1.1065 TD [(Single-center)-335.3(\(vs.)-334(multi-center\))-17587.1(4)-328.3(\(22\))-8223(85)-334.1(\(65\))-7850(0)]TJ 0 -1.1128 TD [(Human)-335.6(development)-335.9(index)-332.8(of)-336.7(recruiting)-333.4(country)-8320.3(0.78)-336.6([0.75,)-329(0.92])-4138.8(0.92)-336.6([0.80,)-329(0.92])-5934.5(0)]TJ T* [(Recruitment)-334.6(setting)]TJ 51.8858 0 TD (1)Tj -50.8868 -1.1128 TD [(Hyper-acute)-24366.4(4)-328.3(\(22\))-8223(23)-334.1(\(18\))]TJ 0 -1.1065 TD [(Acute)-26426.8(14)-327.8(\(78\))-8223(92)-334.1(\(71\))]TJ 0 -1.1128 TD [(Subacute)-25645.4(0)-328.3(\(0\))-8723(14)-334.1(\(11\))]TJ -.999 -1.1128 TD [(Non-routine)-336.1(clinical)-335.6(engagement)]TJ 51.8858 0 TD (0)Tj -50.8868 -1.1128 TD [(None)-27154.3(1)-328.3(\(6\))-8723(68)-334.1(\(52\))]TJ 0 -1.1065 TD [(Baseline)-339.8(only)-23744.6(9)-328.3(\(50\))-8223(23)-334.1(\(18\))]TJ 0 -1.1128 TD [(Follow-up)-336.9(only)-23036.4(0)-328.3(\(0\))-8723(22)-334.1(\(17\))]TJ T* [(Baseline)-339.8(and)-329.7(follow-up)-19802.9(8)-328.3(\(44\))-8223(17)-334.1(\(13\))]TJ -.999 -1.1065 TD [(GOS/GOSE)-339.1(as)-331.4(secondary)-335.4(\(vs.)-334(primary\))-336.3(outcome)-10448.1(1)-328.3(\(6\))-8723(24)-334.1(\(18\))-7850(0)]TJ 0 -1.1128 TD [(Prospective)-334.8(\(versus)-335.4(retrospective\))-340(collection)-334.6(of)-336.7(outcome)-331.4(data)-4806(18)-327.8(\(100\))-7723(85)-334.1(\(65\))-7850(0)]TJ T* [(Follow)-335.8(up)-334.1(at)-334.3(time)-334.5(window)-19412.7(0)-328.3(\(0\))-8723(21)-334.1(\(16\))-7850(0)]TJ T* [(Method)-333(for)-332.5(collecting)-340.9(GOS/GOSE)-332.8(outcome)]TJ 51.3863 0 TD (16)Tj -50.3873 -1.1065 TD [(Exclusively)-335(in)-338.2(person)-20464.2(6)-328.3(\(38\))-8223(36)-334.1(\(33\))]TJ 0 -1.1128 TD [(Partially)-340.2(in)-331.8(person)-21798.4(3)-328.3(\(19\))-8223(42)-334.1(\(39\))]TJ T* [(Not)-334.7(in)-331.8(person)-23707.9(7)-328.3(\(44\))-8223(31)-334.1(\(28\))]TJ -.999 -1.1128 TD [(Proxy)-333.9(report)-337.5(of)-330.4(outcome)-337.8(was)-334.2(accepted)-14510.6(6)-328.3(\(100\))-7723(30)-334.1(\(88\))-7350.5(73)]TJ 7.9702 0 0 7.9702 70.0157 75.2314 Tm [(IQR,)-330.6(interquart)12.1(ile)-335.4(range;)-323(GOSE,)-327.6(Glasgow)-327.7(Outcome)-323.6(Scale)-329.8(Extended.)]TJ 0 -1.131 TD [(The)-366.7(percentage)10(s)-376.1(describe)-366(the)-365.3(proportion)-367.1(of)-369.1(studies)-365(within)-362.5(a)-378.1(catego)11.5(ry)-376.2(when)-367.3(the)-365.3(variable)-370.4(was)-370.6(reported)-365(on.)-364.7(IQR)]TJ /F7 1 Tf 45.6877 0 TD (=)Tj /F4 1 Tf .7184 0 TD [(Interquartile)-363.8(range.)-368.3(Design)-362.8(factors)]TJ -47.409 -1.1239 TD [(which)-328.1(were)-331.2(not)-326.6(reported)-329.4(were)-331.2(subsequent)13.5(ly)-335.8(imputed)-323.5(for)-334.9(the)-329.8(purposes)-319.6(of)-333.6(the)-329.8(model.)]TJ /F1 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (1848)Tj 46.6694 0 TD [(RICHTER)-334.5(ET)-338.7(AL.)]TJ ET endstream endobj 57 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(si)21.1(x)-290.4(m)15.9(on)19.9(th)22.2(s)-285.2(f)0(r)21.1(o)0(m)-274.4(i)0(n)15.9(j)15.4(ur)23.7(y)-290.4(\()0(r)21.1(a)0(n)23.9(g)13.1(e)-292.8(3)13.1()13.1(1)0(2)19.9(0)-284(mo)22.7(nt)22.2(hs)18.8(\))-286.6(a)0(n)23.9(d)-290.4(sc)22.7(h)13.1(e)0(d)17.5(u)13.1(le)19.8(d)-284(a)-286.5(me)20.3(-)]TJ 0 -1.2203 TD [(di)22.2(an)-172.2(o)13.1(f)-179.2(o)13.1(n)13.1(e)-179(fo)23.7(ll)18.2(o)13.1(w)0(-)20.4(u)13.1(p)-182.9(t)15.4(im)18.7(e)-179(p)13.1(o)13.1(i)0(n)22.2(t)-180.6(\(r)21.1(an)23.9(g)13.1(e)-179(1)19.9(5)-176.6(t)0(i)24.5(m)0(e)-169.4(p)13.1(oi)15.9(n)13.1(t)0(s)21.1(\))0(.)-163.1(T)0(h)20.1(e)-179(me)20.3(d)13.1(i)0(a)19.8(n)]TJ 0 -1.2266 TD [(pa)17.5(t)15.4(i)0(e)19.8(n)0(t)-312.9(a)0(t)19.8(t)0(r)19.6(i)15.4(ti)18.2(o)13.1(n)-322(by)-315.2(th)22.2(e)-324.4(e)0(n)17.5(d)-322(o)13.1(f)-324.6(th)22.2(e)-324.4(s)0(t)21.1(u)13.1(dy)-315.2(wa)20.6(s)-323.2(9)13.1(%)-324.1(b)0(u)19.9(t)-326(v)13.1(a)0(r)21.2(i)0(e)19.8(d)-322(wi)18.9(d)13.1(e)0(l)19.8(y)]TJ 0 -1.2203 TD [(fr)21.1(om)-236.5(0)-239.8(t)0(o)-237(8)13.1(8)13.1(%)0(.)-232.2(A)-243.1(su)18.8(mm)25.5(ar)21.2(y)-246.1(o)13.1(f)-248.7(i)15.4(nc)17.5(l)15.4(u)0(d)19.9(e)0(d)-235.4(s)0(t)21.1(u)13.1(d)13.1(i)0(e)19.8(s)-241(is)-238.2(sh)25.1(o)13.1(w)0(n)-236.3(i)0(n)-230.7(T)0(a)17.7(b)13.1(le)-233.1(1)13.1(.)]TJ 1.1128 -1.2203 TD [(The)-310.6(association)-313.5(between)-314.7(patient)-317(attrition)-311.6(and)-310.8(study)-312.6(design)-308.2(was)]TJ -1.1128 -1.2266 TD [(modeled)-299.8(using)-293.6(logistic)-300.3(regression.)-299(The)-291.6(model)-298.4(t)-292.5(the)-302.1(data)-291.4(well)-302.7(ac-)]TJ 0 -1.2203 TD [(cording)-359.7(to)-363.4(the)-359.1(McFadden)-363(Pseudo-R-squared)-360.7(\(median)-365.7(0.52,)-358.5(inter-)]TJ T* [(quartile)-426.6(range)-422.3(0.480.50)-413.4(across)-424.2(20)-422.7(imputed)-421.6(datasets\).)-423.5(Note)-418.8(that)]TJ 0 -1.2266 TD [(values)-342.2(of)-343.1(pseudo-R2)-341.7(tend)-339.6(to)-338.2(be)-342.9(considerably)-342(lower)-345(than)-339.6(those)-340.3(of)]TJ 0 -1.2203 TD [(ordinary)-374.5(R-squared,)-381.2(such)-374.7(that)-368.9(values)-380.2(of)-374.7(0.200.40)-369.2(already)-377.2()54.8(rep-)]TJ T* [(resent)-287.9(an)-279.6(excellent)-282.9(t.)56.6()]TJ 6.7246 0 0 5.9768 145.0771 620.1636 Tm (22)Tj 8.9663 0 0 8.9663 69.7323 605.2534 Tm [(Results)-342.9(of)-343.1(the)-340.1(regression)-340.3(pooled)-338.6(from)-341.9(20)-340.5(imputed)-339.4(datasets)-348.9(are)]TJ -1.1128 -1.2266 TD [(summarized)-213.3(in)-205.4(Table)-202.2(2)-208.2(and)-203.3(illustrated)-213(in)-205.4(Figures)-207.7(2)-201.8(and)-203.3(3.)-211.1(Results)-203.8(of)]TJ 0 -1.2203 TD [(the)-352.7(sensitivity)-354.6(analysis)-352.8(using)-350.5(only)-356.2(the)-352.7(104)-346.3(studies)-357.2(with)-350.8(complete)]TJ T* [(reporting)-314.8(are)-315.8(similar)-315.6(to)-306.5(those)-315(of)-311.4(the)-314.8(primary)-315.3(analysis,)-311.4(bar)-313.4(smaller)]TJ 0 -1.2266 TD [(CIs,)-262.9(and)-253.9(therefore)-261.3(more)-259.5(results)-258.6(that)-261.4(reached)-255.4(statistical)-262.3(signicance)]TJ 0 -1.2203 TD [(\(Supplementary)-287.7(Table)-278.1(S1\).)]TJ 1.1128 -1.2203 TD [(Four)-543(factors)-543(signicantly)-546(increased)-544.2(the)-542.4(odds)-543(of)-539.1(attrition:)-542.7(a)]TJ -1.1128 -1.2266 TD [(greater)-310.2(follow-up)-303(frequency)-305.2(\(odds)-304.9(ratio)-301.5([OR])-302.1(1.16,)-301.5(95%)-304.1(CI)-303.5(1.04)]TJ 0 -1.2203 TD [(1.29\),)-278.4(a)-280.1(single-center)-287.3(as)-274.5(opposed)-278.4(to)-281.3(multi-center)-279.1(design)-282.9(\(OR)-281(1.61,)]TJ T* [(CI)-436.3(1.182.2\),)-431.6(studying)-429(exclusively)-438.8(mild)-433.3(TBI)-429.3(patients)-437.8(compared)]TJ T* [(with)-312.9(all)-306.2(severities)-310.3(\(OR)-312.7(2.78,)-301.5(CI)-309.8(1.584.91\),)-304.6(and)-310.8(collecting)-309.3(GOSE)]TJ 0 -1.2266 TD [(data)-190.3(by)-188.7(mail)-189.1(or)-191.3(telephone)-187.9(but)-185.9(not)-192.2(in)-186.4(person,)-189.6(compared)-192.8(with)-186.4(methods)]TJ 0 -1.2203 TD [(that)-286.7(included)-280.9(a)-280.1(face-to-face)-282.3(assessment)-286.6(\(OR)-281(1.61,)-282.6(CI)-278.2(1.12.38\).)]TJ 1.1128 -1.2203 TD [(Two)-526.5(factors)-530.3(signicantly)-533.3(decreased)-530(the)-529.8(odds)-524(of)-526.4(attrition:)-530.1(a)]TJ -1.1128 -1.2266 TD [(greater)-462(study)-458(duration)-458.1(between)-460.1(injury)-463(and)-456.2(nal)-458.3(follow-up)-461.1(time)]TJ 0 -1.2203 TD [(point)-467.2(\(OR)-470.7(0.93)-463(per)-465.1(six-months)-466.9(interval,)-467.4(CI)-467.9(0.880.99\))-466.1(and)-468.8(re-)]TJ T* [(cruiting)-360.9(among)-357.6(hospital)-359.5(inpatients)-358.7(rather)-358.9(than)-358.6(in)-357.1(the)-359.1(pre-hospital)]TJ 0 -1.2266 TD [(setting)-284.1(or)-279.8(emergency)-283.3(department)-282.1(\(OR)-281(0.58,)-282.6(CI)-278.2(0.470.72\).)]TJ /F1 1 Tf 0 -3.054 TD (Discussion)Tj /F4 1 Tf 1.1128 -1.8336 TD [(Building)-297.4(on)-302.5(a)-292.8(previously)-300.2(published)-298.1(dataset)-303.9(of)-298.8(longitudinal)-301.2(TBI)]TJ -1.1128 -1.2203 TD (studies,)Tj 6.7246 0 0 5.9768 86.9669 368.107 Tm (8)Tj 8.9663 0 0 8.9663 93.5433 364.1385 Tm [(this)-355(review)-365.9(explored)-355.3(which)-361.4(study)-356.8(design)-358.8(factors)-359.6(are)-360.1(as-)]TJ -3.7685 -1.2266 TD [(sociated)-265.5(with)-256(attrition)-261(in)-262.3(longitudinal)-256.9(studies)-262.3(of)-260.9(patients)-260.8(after)-258.2(TBI.)]TJ 0 -1.2203 TD [(The)-367.5(features)-374.2(investigated)-366.4(were)-369.2(based)-370.3(on)-365.7(frequently)-367.3(reported)-370.6(and)]TJ T* [(modiable)-307.8(variables)-305.5(that)-299.4(were)-306(hypothesized)-301.5(to)-300.2(inuence)-303.1(attrition.)]TJ 0 -1.2266 TD [(Patient)-517.9(related)-514(factors)-517.7(affecting)-515.6(follow-up)-511.7(have)-515(been)-515(explored)]TJ 0 -1.2203 TD [(previously)-300.2(in)-300.2(other)-297.5(chronic)-298.9(disease)-301.1(areas)-299.5(including)-300.9(infectious)-300.3(dis-)]TJ T* (eases,)Tj 6.7246 0 0 5.9768 80.9575 302.3432 Tm (23)Tj 8.9663 0 0 8.9663 90.822 298.3748 Tm [(genetic)-347(counseling,)]TJ 6.7246 0 0 5.9768 161.1212 302.3432 Tm (24)Tj 8.9663 0 0 8.9663 170.9858 298.3748 Tm [(and)-342.4(psychiatric)-352.8(conditions)]TJ 6.7246 0 0 5.9768 267.0802 302.3432 Tm (25)Tj 8.9663 0 0 8.9663 276.9448 298.3748 Tm (where)Tj -24.2231 -1.2267 TD [(loss)-371.2(to)-369.8(follow-up)-366.2(is)-364.6(common.)-369.9(For)-366.5(example,)-374.7(study)-363.2(site,)-373(treatment)]TJ 0 -1.2203 TD [(setting,)-293.4(living)-287.3(situation,)-290.1(and)-285.5(employment)-287(status)-294.4(are)-290.5(just)-285.5(some)-289.7(fac-)]TJ T* [(tors)-284.1(associated)-280.8(with)-281.3(follow-up)-284(in)-281.2(psychiatric)-283.3(research.)]TJ 6.7246 0 0 5.9768 255.3448 269.4614 Tm (25)Tj 8.9663 0 0 8.9663 69.7323 254.5511 Tm [(Unsurprisingly,)-569.1(increasing)-564.3(frequency)-564.5(of)-564.4(follow-up)-568.6(within)-562.5(a)]TJ -1.1128 -1.2266 TD [(study)-527.6(was)-523.9(associated)-533.7(with)-521.5(greater)-531.5(odds)-524(of)-526.4(attrition)-526.6(or)-520.1(overall)]TJ 0 -1.2203 TD [(dropout.)-259(Asking)-258.5(patients)-260.8(to)-262.3(participate)-263.3(in)-256(multiple)-258.4(follow-up)-265.1(visits)]TJ T* [(was)-207.8(associated)-204.9(with)-205.4(an)-203.8(increased)-209.1(likelihood)-203.3(of)-204(their)-206.6(missing)-206.5(at)-201.5(least)]TJ 0 -1.2266 TD [(one.)-383.2(The)-386.5(reasons)-385.8(for)-383.1(dropping)-382.1(out)-381.9(or)-381(missing)-383.6(a)-387.6(follow-up)-385.2(event)]TJ 0 -1.2203 TD [(were)-337.6(not)-331.3(explored)-330(but)-331.3(may)-333.3(be)-330.2(related)-336.9(to)-331.8(patients)-330.3(tiring)-334.2(of)-330.4(the)-333.8(re-)]TJ T* [(peated)-286.5(demands)-278(on)-283.6(their)-282.5(time.)]TJ 1.1128 -1.2266 TD [(The)-190.5(use)-185.5(of)-185(multiple)-188.8(follow-up)-189.2(points,)-186.3(however,)-187.3(is)-187.6(not)-185.9(uncommon)]TJ -1.1128 -1.2203 TD [(in)-237(TBI)-239.6(research)-233.5(because)-241.4(of)-235.6(the)-232.6(chronicity)-242.2(of)-229.2(the)-238.9(disease.)-240.8(Outcomes)]TJ T* [(can)-427(change)-428(for)-427.4(both)-419.4(better)-429.9(or)-425.3(worse,)-427.3(sometimes)-422.6(years)-429.8(after)-422.6(the)]TJ T* [(initial)-240.4(injury,)-238.3(and)-241.2(there)-236.6(is)-238.2(no)-233(clear)-245.4(consensus)-238(on)-239.3(the)-232.6(optimal)-242.2(timing)]TJ 0 -1.2266 TD [(of)-191.3(outcome)-198.7(assessment.)]TJ 6.7246 0 0 5.9768 143.8299 137.9905 Tm (26)Tj 8.9663 0 0 8.9663 152.2771 133.9653 Tm [(In)-191.3(studies)-192.8(with)-192.8(multiple)-195.2(follow-up)-189.2(points,)]TJ -10.319 -1.2203 TD [(the)-365.4(missing)-364.6(data)-361(handling)-360.6(technique)-365(of)-362(last)-363.8(outcome)-363.1(carried)-367.1(for-)]TJ T* [(ward)-404.7(is)-402.6(used)-400(frequently)-398.9(to)-401.4(minimize)-399.4(missing)-402.6(data)-398.9(and)-405.6(therefore)]TJ 0 -1.2266 TD [(optimize)-231.5(total)-227(outcome)-224(data.)-224.8(The)-228.4(limitations)-228.2(of)-222.9(this)-228.6(technique)-225.9(have)]TJ 0 -1.2203 TD [(been)-338(debated)-330.3(previously)-331.8(because)-336.2(it)-335.9(assumes)-331(the)-333.8(absent)-329.6(data)-335.7(have)]TJ T* [(remained)-285.4(unchanged)-281.1(with)-281.3(time.)]TJ 6.7246 0 0 5.9768 174.0472 83.1685 Tm (27)Tj 8.9663 0 0 8.9663 69.7323 68.2015 Tm [(In)-336.7(the)-340.1(case)-341.6(of)-343.1(studies)-338.2(with)-338.2(multiple)-340.6(time)-340.8(points,)-338(the)-340.1(nal)-344.5(time)]TJ -1.1128 -1.2203 TD [(point)-403.9(was)-403.8(used)-400(to)-401.4(calculate)-405.5(overall)-397.8(attrition)-406.4(for)-402.1(that)-400.5(study,)-397.7(with)]TJ 28.0042 13.4552 TD [(attrition)-431.7(often)-430.2(being)-427.6(highest)-431.9(at)-429.1(that)-425.8(time.)-432.3(Therefore,)-430.7(one)-430.9(would)]TJ 0 -1.2203 TD [(assume,)-301.6(the)-295.8(longer)-297(the)-302.1(duration)-300(of)-292.5(a)-299.1(study,)-302.9(the)-295.8(higher)-297(the)-302.1(dropout)]TJ 0 -1.2266 TD [(rate.)-278(Within)-283(our)-279.4(dataset,)-281.5(however,)-282.1(the)-283.2(opposite)-279.6(was)-277.3(found.)-281.3(Across)]TJ 0 -1.2203 TD [(all)-280.9(studies,)-290.5(the)-283.2(longer)-284.3(the)-283.2(duration,)-284(the)-283.2(lower)-288.1(the)-283.2(odds)-283.8(of)-286.2(attrition.)]TJ T* [(To)-315(clarify)-318.2(this)-317.1(relation)-312.8(further,)-317.3(imagine)-322.8(two)-315.7(studies)-312.9(that)-318.3(followed)]TJ 0 -1.2266 TD [(patients)-235.5(for)-237.7(the)-238.9(same)-235.2(periodfor)-242.8(example,)-235.6(one)-234.9(year.)-242.4(It)-233.3(is)-238.2(the)-238.9(study)]TJ 0 -1.2203 TD [(with)-357.2(the)-359.1(lower)-357.7(follow-up)-359.9(frequency)-355.8(during)-357.8(that)-356.3(year)-359.6(that)-362.6(experi-)]TJ T* [(enced)-283(lower)-281.8(patient)-279(attrition.)]TJ 1.1128 -1.2266 TD [(In)-241.9(contrast,)-243.3(take)-240.9(two)-246.1(studies)-243.4(with)-243.3(the)-245.2(same)-241.5(number)-245.9(of)-241.9(follow-up)]TJ -1.1128 -1.2203 TD [(time)-347.1(points.)-344.3(It)-340.8(is)-345.7(the)-346.4(study)-344.2(with)-344.5(the)-346.4(greater)-348.2(duration)-344.3(between)-346.3(the)]TJ T* 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19.899 re f 407.622 454.45 21.827 19.899 re f 435.458 454.45 43.427 19.899 re f 484.838 454.45 20.636 19.899 re f 511.483 454.45 38.438 19.899 re f 310.847 404.617 239.074 19.956 re f 310.847 384.718 90.765 9.978 re f 407.622 384.718 21.827 9.978 re f 435.458 384.718 43.427 9.978 re f 484.838 384.718 20.636 9.978 re f 511.483 384.718 38.438 9.978 re f 310.847 364.762 239.074 9.9779 re f 310.847 344.863 90.765 9.9779 re f 407.622 344.863 21.827 9.9779 re f 435.458 344.863 43.427 9.9779 re f 484.838 344.863 20.636 9.9779 re f 511.483 344.863 38.438 9.9779 re f 310.847 314.986 90.765 9.9212 re f 407.622 314.986 21.827 9.9212 re f 435.458 314.986 43.427 9.9212 re f 484.838 314.986 20.636 9.9212 re f 511.483 314.986 38.438 9.9212 re f 310.847 295.03 90.765 9.9779 re f 407.622 295.03 21.827 9.9779 re f 435.458 295.03 43.427 9.9779 re f 484.838 295.03 20.636 9.9779 re f 511.483 295.03 38.438 9.9779 re f 310.847 265.153 90.765 9.978 re f 407.622 265.153 21.827 9.978 re f 435.458 265.153 43.427 9.978 re f 484.838 265.153 20.636 9.978 re f 511.483 265.153 38.438 9.978 re f 0 0 0 rg 310.847 690.236 239.074 .22668 re f 310.847 251.376 239.074 .22675 re f 310.847 648.51 239.074 .28345 re f BT /F6 1 Tf 8.9663 0 0 8.9663 336.1889 725.7825 Tm (Table)Tj /F4 1 Tf 2.9971 0 TD (2.)Tj /F6 1 Tf 1.2519 0 TD [(The)-333.3(Effect)-330.5(of)-335.1(Study)-334.6(Design)-332.8(Factors)]TJ -3.212 -1.1128 TD [(on)-332.5(the)-333.5(Odds)-334.8(of)-335.1(Patient)-332.7(Attrition)-334.1(by)-332.7(the)]TJ .3667 -1.1128 TD [(End)-331.9(of)-335.1(the)-333.5(Study)-334.6(Based)-335.8(on)]TJ /F4 1 Tf 12.9873 0 TD (148)Tj /F6 1 Tf 1.8336 0 TD (Studies)Tj -11.8871 -1.1065 TD [(of)-328.8(Traumatic)-336.3(Brain)-333.5(Injury)]TJ /F9 1 Tf 3.7937 -3.446 TD (Odds)Tj .0822 -1.1128 TD (ratio)Tj 4.3628 2.2257 TD (95%)Tj -1.3405 -1.1128 TD (Condence)Tj .6702 -1.1128 TD (Interval)Tj /F4 1 Tf 5.5768 0 TD (p)Tj /F9 1 Tf 2.0676 0 TD (Signicant)Tj /F4 1 Tf -22.3768 -2.0929 TD [(Total)-336.6(no.)-330.7(of)-330.4(follow-up)]TJ .999 -1.1128 TD [(time)-334.5(points)]TJ 10.1356 1.1128 TD [(1.16)-1436.8(1.041.29)-1633.7(0.01)-2562.2(*)]TJ -11.1346 -2.2193 TD [(Study)-329(duration)-337.9(\(per)-334.5(6-)]TJ .999 -1.1128 TD [(month)-333.9(interval\))]TJ 10.1356 1.1128 TD [(0.93)-1436.8(0.880.99)-1633.7(0.03)-2562.2(*)]TJ -11.1346 -2.2257 TD [(Observational)-336.2(study)-331.6(\(vs.)]TJ .999 -1.1128 TD (interventional\))Tj 10.1356 1.1128 TD [(1.41)-1436.8(0.593.32)-1633.7(0.31)]TJ -11.1346 -2.2193 TD [(Prospective)-334.8(study)-331.6(\(vs.)]TJ .999 -1.1128 TD (retrospective\))Tj 10.1356 1.1128 TD [(1.26)-1436.8(0.413.87)-1633.7(0.41)]TJ -11.1346 -2.2257 TD [(GOS)-332.5(as)-337.7(secondary)]TJ .999 -1.1128 TD [(outcome)-331.4(\(vs.)-334(primary\))]TJ 10.1356 1.1128 TD [(1.73)-1436.8(0.525.75)-1633.7(0.16)]TJ -11.1346 -2.2193 TD [(Use)-334.2(of)-330.4(follow-up)-334.6(time)]TJ .999 -1.1128 TD [(window)-336.5(\(vs.)-334(discrete)]TJ T* [(time)-334.5(points\))]TJ 10.1356 2.2257 TD [(1.15)-1436.8(0.642.07)-1633.7(0.52)]TJ -11.1346 -3.3385 TD [(Single-center)-335.3(study)-331.6(\(vs.)]TJ .999 -1.1065 TD (multi-center\))Tj 10.1356 1.1065 TD [(1.61)-1436.8(1.182.2)-2133.7(0.01)-2562.2(*)]TJ -11.1346 -2.2193 TD [(Percentage)-334.9(of)-336.7(male)]TJ .999 -1.1128 TD (patients)Tj 10.1356 1.1128 TD [(0.98)-1436.8(0.961)-2883.7(0.04)]TJ -11.1346 -2.2193 TD [(Mean)-332.4(age)-338.5(of)-330.4(study)]TJ .999 -1.1128 TD (population)Tj 10.1356 1.1128 TD [(0.99)-1436.8(0.931.05)-1633.7(0.45)]TJ -11.1346 -2.2257 TD [(Human)-335.6(development)]TJ .999 -1.1128 TD [(index)-332.8(of)-336.7(recruiting)]TJ 0 -1.1065 TD (country)Tj 10.1356 2.2193 TD [(3.37)-2113.3(0.04)]TJ /F7 1 Tf 5.7791 0 TD (-)Tj /F4 1 Tf -1.9728 -1.1128 TD (308.49)Tj 5.0141 1.1128 TD (0.37)Tj -19.9551 -3.3322 TD [(Injury)-335.1(severity)-335.2(\(compared)-334.1(with)-331.9(using)-337.9(patients)]TJ .999 -1.1128 TD [(of)-330.4(mixed)-336.3(severity\))]TJ T* [(Mild)-8188.6(2.78)-1436.8(1.584.91)-1633.7(0.01)-2562.2(*)]TJ 0 -1.1065 TD [(Moderate)-333.1(to)-338.2(severe)-2284.4(0.66)-1436.8(0.281.53)-1633.7(0.19)]TJ 0 -1.1128 TD [(Severe)-334.3(only)-5294.3(0.74)-1436.8(0.134.12)-1633.7(0.42)]TJ -.999 -1.1128 TD [(Recruitment)-334.6(setting)-334.7(\(compared)-340.4(with)-331.9(the)-333.8(hyperacute)-333.9(setting\))]TJ .999 -1.1065 TD [(Acute)-7742.6(0.58)-1436.8(0.470.72)]TJ /F7 1 Tf 18.406 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(0.01)-2562.2(*)]TJ -18.9561 -1.1128 TD [(Subacute)-6461.6(0.90)-1436.8(0.362.26)-1633.7(0.74)]TJ -.999 -1.1128 TD [(Level)-335(of)-330.4(non-routine)-339.1(engagement)-334.8(\(compared)-334.1(with)-338.2(no)-327.8(such)]TJ .999 -1.1128 TD (engagement\))Tj 0 -1.1065 TD [(Baseline)-333.4(only)-4567.2(0.63)-1436.8(0.351.13)-1633.7(0.09)]TJ 0 -1.1128 TD [(Follow-up)-330.6(only)-3859(1.56)-1936.3(0.83.02)-1634.2(0.12)]TJ T* [(B)14.7(a)17(se)29(li)24.6(n)19.5(e)-267.5(an)30.2(d)-265.1(f)0(o)30(l)15.4(l)15.4(o)13.1(w)16.1(-)0(u)30(p)-1011.2(1.94)-1436.8(0.389.99)-1633.7(0.21)]TJ -.999 -1.1128 TD [(Method)-333(of)-330.4(GOS)-338.8(collection)-334.6(\(compared)-334.1(with)-338.2(collection)]TJ .999 -1.1065 TD [(exclusively)-337.6(in)-331.8(person\))]TJ 0 -1.1128 TD [(Partially)-333.9(in)-331.8(person)-2621(1.33)-1436.8(0.483.67)-1633.7(0.33)]TJ T* [(Not)-334.7(in)-331.8(person)-4524.2(1.61)-1936.3(1.12.38)-1634.2(0.03)-2562.2(*)]TJ 7.9702 0 0 7.9702 318.7841 239.5275 Tm [(GOS,)-329.9(Glasgow)-327.7(Outcome)-323.6(Scale.)]TJ 0 -1.1239 TD [(Attrition)-285.5(was)-292.3(modeled)-285.5(using)-280.9(logistic)-287.6(regression)-284.9(and)-288.6(results)-290.2(were)-288.5(pooled)]TJ -.9958 -1.1239 TD [(across)-284.3(20)-287.5(multiply)-279.6(imputed)-280.8(datasets.)-290.1(The)-281.3(column)-284.4()62.7(Signicant)70.5()-285.9(highlights)]TJ T* [(where)-329.1(the)-329.8(condence)-326.2(interval)11.3(s)-333.4(d)0(o)-330.2(not)-333.7(include)-323.2(1.0.)]TJ /F1 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(STUDY)-335.9(DESIGN)-336.8(FEATURES)-342.3(ASSOCIATED)-333.4(WITH)-335.9(ATTRITION)-23740.1(1849)]TJ ET endstream endobj 61 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 177.9023 Tm 0 0 0 rg 0 Tc 0 Tw [(complete)-242.5(outcome)-236.6(data)-240.8(by)-233(focusing)-240.3(on)-239.3(a)-235.9(single)-236.3(and)-241.2(later)-234.3(follow-up)]TJ 0 -1.2203 TD [(time)-385.1(point.)-375.2(A)-382.2(limitation)-385.6(of)-374.7(this)-380.3(analysis)-384.4(is)-383.6(that)-381.6(few)-379.9(studies)-382.5(con-)]TJ 0 -1.2266 TD [(sidered)-382.3(follow-up)-378.9(beyond)-378.9(two)-378.9(years,)-382.2(and)-380.3(hence)-384.2(attrition)-381.1(at)-378.5(truly)]TJ 0 -1.2203 TD [(long)-280.3(follow-up)-284(time)-277.6(points)-284.5(could)-275.9(not)-280.8(be)-279.6(analyzed.)]TJ 1.1128 -1.2203 TD [(This)-483.6(seemingly)-481.1(paradoxical)-489.2(relation)-483.5(may)-485(be)-482(explained)-485.1(by)-485.9(a)]TJ -1.1128 -1.2266 TD [(number)-283.8(of)-279.8(putative)-278.6(reasons)-283.6(for)-282(example,)-286.2(the)-276.9(increasing)-286.1(prepon-)]TJ 0 -1.2203 TD [(derance)-274.4(of)-273.5(patients)-273.4(who)-273.7(have)-274.8(died)-270(during)-275.6(the)-270.5(study)-274.7(period)-271.7(and)-272.8(are)]TJ T* [(therefore)-292.9(known)-285.4(to)-287.6(be)-286(GOS)-288.3(1.)-287(Patients)-291(with)-287.6(TBI)-290.2(have)-287.4(chronically)]TJ 0 -1.2266 TD [(increased)-398.8(death)-392.1(from)-398.8(all)-394.7(causes)-398.7(compared)-395.2(with)-395.1(non-TBI)-392(trauma)]TJ 0 -1.2203 TD [(matched)-314.9(controls,)-310.4(and)-310.8(it)-310.6(is)-314.1(often)-310.1(easier)-309.3(to)-312.9(establish)-312.1(the)-314.8(death)-309.9(of)-311.5(a)]TJ T* [(patient)-215.8(from)-215.4(death)-221.4(registries)-215.6(than)-219.5(the)-213.6(functional)-217(status)-218.6(of)-210.3(those)-220.2(who)]TJ 0 -1.2266 TD [(are)-284.2(still)-280.4(alive.)]TJ 6.7246 0 0 5.9768 111.4015 61.3417 Tm (28)Tj 8.9663 0 0 8.9663 323.0361 177.9023 Tm [(Alternatively,)-459.8(early)-457.9(follow-up)-454.8(runs)-457.1(the)-460.2(risk)-454.8(of)-456.9(clashing)-452.8(with)]TJ -1.1128 -1.2203 TD [(clinical)-215.4(commitments)-213(from)-215.4(other)-208.9(injuries)-216.7(or)-210.3(patients)-216.5(may)-206.8(be)-216.4(unable)]TJ 0 -1.2266 TD [(to)-376.1(attend)-370.3(early)-375.7(on)-365.8(because)-374.2(of)-374.7(on-going)-369.4(TBI)-372.4(rehabilitation.)-371.5(Simi-)]TJ 0 -1.2203 TD [(larly,)-443.5(most)-436.7(patients)-444.1(improve)-439.1(functionally)-435(with)-439.4(time)-442(and)-437.2(have)-439.2(a)]TJ T* [(greater)-316.6(capacity)-317.3(to)-306.5(engage)-314.2(with)-312.9(follow-up)-309.3(after)-315.1(an)-311.3(increased)-316.6(time)]TJ 0 -1.2266 TD [(after)-264.5(injury.)-257.2(Further,)-256.3(patients)-260.8(are)-258.9(often)-259.5(advised)-259.5(that)-261.4(symptoms)-256.2(will)]TJ 0 -1.2203 TD [(continue)-363.1(to)-363.4(change)-364.7(and)-361.4(often)-360.7(improve)-363.2(for)-364.1(at)-359.5(least)-365.7(one)-361.4(year)-359.6(after)]TJ T* [(injury.)-377.4(Persistence)-376.3(of)-374.7(symptoms)-370(beyond)-378.9(this)-367.7(period)-379.2(may)-371.2(prompt)]TJ 0 -1.2266 TD [(them)-286.2(to)-274.9(engage)-282.5(with)-281.3(follow-up)-284(more)-278.5(than)-282.7(previously.)]TJ 1.1128 -1.2203 TD [(The)-329.6(majority)-326.5(of)-330.4(the)-327.4(reasons)-328.9(described,)-329.7(however,)-332.7(assume)-330.3(a)-324.4(rel-)]TJ -1.1128 -1.2203 TD [(atively)-475.1(high)-476.3(degree)-474.8(of)-469.5(disease)-478.1(severity)-474.3(and)-468.8(on-going)-470.6(symptom)]TJ 0 -1.2266 TD [(burden.)-289.5(A)-293.7(more)-284.8(plausible)-291.9(option)-289.6(is)-288.8(likely)-289.8(to)-287.6(be)-292.3(the)-289.5(presence)-294.1(of)-286.2(an)]TJ ET q 420.92 0 0 416.296 96.775 315.949 cm /Im2 Do Q BT /F5 1 Tf 8.9663 0 0 8.9663 62.022 299.1685 Tm .0104 Tc [(FIG.)-340.3(2.)]TJ /F4 1 Tf 4.1794 0 TD .0106 Tc [(Illu)10.6(s)-8.6(t).7(ratio)10.6(n)-348.8(o)10.6(f)-345.1(t).7(he)-339.1(asso)10.6(c)-9.8(i).7(ation)-336.7(b)-1.6(et)-5.6(ween)-336.7(st)-5.6(u)10.6(d)-7.4(y)-336.7(d)-1.6(esign)-336.7(f)2.2(actors)]TJ 25.0261 0 TD .0108 Tc [(an)10.8(d)-348.6(p)10.8(a)-9.6(tient)-340.5(attritio)10.8(n)-7.2(,)-339.9(based)-336.5(o)-1.4(n)-336.5(1)-1.4(48)-336.5(stu)10.8(d)-7.2(ies)-344(o)10.8(f)-344.9(t).9(raumatic)-345.2(b)10.8(r)-3.5(ain)]TJ -29.2055 -1.1128 TD .0104 Tc [(inju)10.4(r)-10.2(y)-431.7(usin)10.4(g)-443.9(a)-434.1(log)10.4(i)-11.6(stic)-440.5(regressio)10.4(n)-443.9(mod)10.4(e)-10(l.)-435.1(To)10.4(p)-443.9(r)2(ow:)-435.7(A)1.3(ttritio)10.4(n)-443.9(b)-1.8(ased)]TJ 28.9589 0 TD [(o)10.3(n)-444(recruitment)-435.8(s)-3(etting)-431.8(a)-4.3(n)10.3(d)-444(inju)10.3(r)-10.3(y)-431.8(severity)10.3(.)-441.1(T)-1.7(he)-434.2(three)-440.6(p)10.3(a)-10.1(n)-1.9(els)]TJ -28.9589 -1.1128 TD .0101 Tc [(rep)10.1(r)-10.5(esent)-341.2(t).2(h)10.1(e)-351.7(th)10.1(r)-10.5(e)1.9(e)-339.6(s)-3.2(etti)-6.1(n)10.1(g)-7.9(s)-338.4(i).2(n)-343.5(w)1(hich)-343.5(p)10.1(a)-10.3(tients)-344.7(w)1(ere)-345.9(r)1.7(ecruited:)-341.2(in)-343.5(th)]TJ 27.6759 0 TD .0104 Tc [(e)-351.4(p)10.4(r)-10.2(e)2.1(-hospital)-340.9(s)-2.9(etting)-336.9(o)-1.8(r)-339.5(e)-4.2(merg)10.4(e)-10(n)]TJ 13.8598 0 TD .0106 Tc [(c)-9.8(y)-336.7(department)-340.7(\(Hyperacute\),)-340.1(as)]TJ -41.5357 -1.1065 TD .0102 Tc [(ho)10.2(s)-9(p)-2(ital)-385.3(i).3(n)10.2(p)-7.8(ati)-6(e)2(nts)-382.5(o)10.2(n)-387.2(w)-5.3(ards)-382.5(or)-383.9(in)10.2(t)-5.5(e)-4.4(n)10.2(s)-9(ive)-383.7(care)-383.7(u)10.2(n)-7.8(its)-382.5(\(A)-5.3(cute\),)-384.7(in)-381.3(ou)]TJ 28.03 0 TD .0101 Tc [(t)-11.9(p)10.1(a)-10.3(tient)-379.1(clin)10.1(i)-11.9(c)1.8(s)-382.6(o)-2.1(r)-377.7(r)-4.7(ehabilitat)-6.1(i).2(o)10.1(n)-387.3(faci)-6.1(lities)-382.6(\()-4.7(S)10.1(u)-6.5(bacute\).)-384.8(T)10.1(h)-7.7(e)-383.8(lines)]TJ -28.03 -1.1128 TD .0105 Tc [(rep)10.5(r)-10.1(esent)-302.9(s)3.5(tudies)-306.3(recruiting)-298.8(p)-1.7(at)-5.7(ients)-300(o)-1.7(f)-301.4(d)-1.7(iffe)]TJ 18.1468 0 TD .0103 Tc [(ren)10.3(t)-315.2(in)10.3(j)-5.4(u)-1.9(ry)-305.4(severities.)-308.8(Note)-301.4(that)-303.1(the)-307.8(lin)10.3(e)-10.1(s)-300.2(fo)10.3(r)-313.8()]TJ 18.8676 0 TD .0111 Tc [(mo)11.1(d)-6.9(erate)-307(&)-301.8(sev)11.1(e)-9.3(re)59.6()-300.8(pat)-5.1(i)1.2(ents)-299.4(an)11.1(d)-310.4()53.2(sev)11.1(e)-9.3(r)2.7(e)]TJ -37.0143 -1.1128 TD .0109 Tc [(on)10.9(l)-4.8(y)-1.3()53()-275.7(p)10.9(a)-9.5(tients)-280.6(o)10.9(v)-7.1(e)2.6(rlap.)-276.5(B).3(o)10.9(t)-4.8(t)-5.3(o)10.9(m)-282.5(r)-3.9(o)10.9(w)-4.1(:)-277.2(A)-4.6(ttrition)-273.1(b)-1.3(ased)-279.5(on)-273.1(recru)10.9(i)-4.8(ti)-5.3(n)10.9(g)-285.3(cen)10.9(t)-4.8(ers)-274.3(a)-3.7(nd)-273.1(meth)10.9(o)-7.1(d)-279.5(o)10.9(f)-287.9(Glasg)10.9(o)-7.1(w)-276.4(O)1.8(utco)10.9(m)-4.3(e)-281.9(Scale)-281.9(E)-1.1(x)10.9(t)-4.8(en)10.9(d)-7.1(e)2.6(d)-279.5(\()2.5(GO)-4.6(SE)10.9(\))]TJ 0 -1.1065 TD [(collection)10.9(.)-263.4(The)-256.6(t)1(hree)-256.6(p)10.9(a)-9.5(nels)-255.4(represent)-258.2(t)1(he)-256.6(th)]TJ 17.9824 0 TD [(ree)-262.9(m)1.5(etho)10.9(d)-7.1(s)-255.4(of)-256.8(co)10.9(llection)-260.5(f)2.5(o)10.9(r)-268.9(th)10.9(e)-268.8(GOSE\):)-258.2(o)-1.3(n)10.9(l)-4.8(y)-260.5(f)2.5(ace-to)10.9(-)-9.7(f)2.5(ace)-256.6(\()2.5(Exclus)3.9(ively)-260.5(i)1.1(n)-260.5(p)10.9(e)-9.5(r)2.5(s)3.9(on\),)-257.6(s)3.9(ome)]TJ -17.9824 -1.1128 TD .0106 Tc [(patien)10.6(t)-5.1(s)-287.3(b)-1.6(eing)-286.1(interv)10.6(i)-5.1(e)-4(wed)-286.1(f)-4.2(ace-to-face)-288.5(wit)-5.6(h)-286.1(o)10.6(t)-5.1(hers)-287.3(b)10.6(e)-9.8(in)10.6(g)-291.9(c)-4(on)10.6(t)-5.1(a)-4(ct)]TJ 26.8471 0 TD .011 Tc [(ed)-285.7(b)11(y)-291.5(telepho)11(n)-7(e)-288.1(o)11(r)-294.1(mail)-283.4(\(Partially)-285.7(in)-285.7(perso)11(n)-7(\),)-289.1(use)-288.1(o)-1.2(f)-282(only)-285.7(t)1.1(elep)11(h)-7(o)-1.2(n)11(e)]TJ -26.8471 -1.1128 TD [(and/o)11.1(r)-338.3(mail)-333.9(\(Not)-333.9(in)-329.8(pers)4.1(on)11.1(\))-9.5(.)]TJ /F1 1 Tf 0 59.1319 TD 0 Tc (1850)Tj 46.6694 0 TD [(RICHTER)-334.5(ET)-338.7(AL.)]TJ ET endstream endobj 63 0 obj <>stream AdobedC       dm s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?Nlٳf͛6lٳf͛6lٳ~z˾Fx[K3Ik dJwD^i֯tgʾdk3yRK;˙Md%sv0Wl?:Ƶgo{)<I8,,ߗ7͛̚G,yb⑳#5_[ Hh: *伮QO+sO6goʫ)-jP->s`D'6&˞bɚCi OVZȊ$}?$iGk=LQLvV0lhƀ|o6#prf,:7]YǙ#kkPeQhhXdE C+)9Wթi?I:h7&ON1Wroo%y̾]mu78P{4j{Ҙ3/vziݸ>%WZjᶑMXWX/4R\EhQVh:צ韛ߖ:42\j,4Y@,iXXץ>f4uB :{ 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J7JUiԽFKAĖ+r]^5N4nx&;%?kd*էLO5qOuKuH;6z\KˈNTҽJW]ӭ3To5;lSl|БFn+aVߊϕ9}Zg9ֵMo̾_Jc$ZV@tP\Z-yWVfw#-`@6ڽqھyL Kv~{1KKN)t!h>H糾ⶶn/?ܱ䍳Ւz)3y;sԴ֙GKα$۲(žlܱǹϧWѿX3̠'*((7כvľoZykQ[,wC'ta{DIV9jhv̾d򦍥k^_[-؈)2ik49~akHtzYjֺ6US, K,Ei@ 'uұ!^;ªƧƘΝڰIذ;˲ܖӭ*4>)ӾԮo{=եT5$jV5 +րS6y:guKft7)b3T)A~Tizt_MMZML$j_}ZrϨ=Ԇ:袼O٧?.ol uj -Ջaed\Zk ]I(Uf,$eq= ?-:l7<.<%KJ>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 375.1369 Tm 0 0 0 rg 0 Tc 0 Tw [(unmeasured)-521.9(confounder)-517.3(such)-520.1(as)-514.8(greater)-525.2(funding)-515.4(and)-519.4(therefore)]TJ 0 -1.2203 TD [(greater)-468.3(efforts)-460.9(for)-465.3(follow-up)-461.1(in)-458.3(studies)-464.7(of)-463.2(longer)-461.4(duration.)-461(Re-)]TJ T* [(gardless)-218.6(of)-210.3(the)-213.6(cause,)-217.6(the)-213.6(effect)-215.9(size)-216.7(is)-212.9(small)-215.1(and)-215.9(unlikely)-212.9(to)-211.7(change)]TJ 0 -1.2266 TD [(patient)-285.4(retention)-280.7(substantially)-286.5(in)-274.9(planning)-284.8(of)-279.8(future)-280.6(studies.)]TJ 1.1128 -1.2203 TD [(Mild)-354.5(TBI)-353.4(was)-353.2(associated)-356.6(with)-350.8(poorer)-352.5(follow-up)-353.6(relative)-353.1(to)-350.8(all)]TJ -1.1128 -1.2203 TD [(severities)-379.8(of)-374.7(TBI,)-375.3(consistent)-374.8(with)-369.8(previous)-379.4(studies)-369.8(in)-376.1(TBI.)]TJ 6.7246 0 0 5.9768 276.2078 324.3401 Tm (7)Tj 8.9663 0 0 8.9663 282.8976 320.3716 Tm (This)Tj -24.887 -1.2267 TD [(may,)-374.1(at)-365.9(least)-372(in)-369.8(part,)-370.4(be)-374.5(secondary)-367.1(to)-369.8(asymptomatic)-375.8(patients)-368.3(not)]TJ 0 -1.2203 TD [(perceiving)-265.9(any)-260.2(relevance)-260.9(of)-260.9(attending)-265.4(follow-up,)-261.7(and)-260.2(the)-257.9(nature)-261.4(of)]TJ T* [(their)-307.8(brief)-306.4(encounter)-306.7(in)-306.5(the)-308.5(emergency)-308.6(department)-307.4(means)-304.3(they)-308(do)]TJ 0 -1.2266 TD [(not)-331.3(have)-331.7(the)-327.4(same)-330.1(investment)-332.9(in)-325.5(returning.)-330.3(The)-329.6(lack)-329.4(of)-330.4(represen-)]TJ 0 -1.2203 TD [(tation)-397.2(of)-393.6(patients)-393.6(with)-395.1(mild)-395.3(TBI)-391.4(will)-392.8(undoubtedly)-397.1(bias)-391.4(outcome)]TJ T* [(data,)-288(and)-291.8(while)-289.5(high)-286.6(attrition)-286.3(in)-287.6(this)-285.5(patient)-291.7(group)-284.7(is)-288.8(likely)-289.8(to)-287.6(cor-)]TJ 0 -1.2266 TD [(relate)-229.9(with)-230.7(good)-225.7(outcomes,)]TJ 6.7246 0 0 5.9768 156.5291 247.6346 Tm (29)Tj 8.9663 0 0 8.9663 165.3165 243.6094 Tm [(it)-228.4(should)-223.6(not)-223.9(be)-229.1(assumed)-228.6(that)-229.8(patients)]TJ -11.7733 -1.2203 TD [(who)-280(do)-283.6(not)-280.8(attend)-281.8(follow-up)-277.7(are)-284.2(therefore)-280.3(doing)-279.8(well.)]TJ 1.1128 -1.2203 TD [(It)-340.8(might)-344.2(be)-336.6(expected)-344.9(that)-343.6(single)-343.8(centers)-340.4(would)-340(be)-342.9(better)-341.3(at)-346.9(re-)]TJ -1.1128 -1.2203 TD [(taining)-245(patients)-241.8(at)-245.7(follow-up.)-242.7(Our)-238.4(results,)-248.9(however,)-244.2(suggest)-239.3(studies)]TJ 0 -1.2266 TD [(involving)-406(single)-400.7(centers)-403.7(have)-401.2(poorer)-403(patient)-405.5(retention)-400.8(compared)]TJ 0 -1.2203 TD [(with)-458.3(studies)-452(involving)-450.3(multiple)-454.4(centers.)-457.2(This)-452(again)-455.3(may)-453.4(reect)]TJ T* [(confounders)-473.8(involved)-468.1(in)-464.6(multi-center)-475.1(studies)-471(such)-469.5(as)-464.2(increased)]TJ 0 -1.2266 TD [(funding)-401.6(and)-399.3(level)-402.5(of)-393.6(planning)-404.9(invested)-395.9(to)-401.4(perform)-402.4(such)-400(studies.)]TJ 0 -1.2203 TD [(Multi-center)-402.8(studies)-401.4(are)-404.3(also)-397.7(more)-398.6(likely)-403.6(to)-401.4(include)-395.2(randomized)]TJ T* [(controlled)-235.9(trials)-236.6(or)-235.6(large-scale)-242.5(observational)-238.1(studies)-237(with)-230.7(increased)]TJ 0 -1.2266 TD [(research)-284(resources)-288.7(and)-279.2(personnel)-280.1(dedicated)-285.2(to)-281.3(perform)-282.2(follow-up.)]TJ 1.1128 -1.2203 TD [(Unsurprisingly,)-379.4(the)-371.7(method)-380.1(of)-374.7(GOSE)-376.1(collection)-372.5(was)-378.5(found)-373.2(to)]TJ -1.1128 -1.2203 TD [(inuence)-252.5(attrition.)-257.6(Studies)-247.1(that)-255.1(did)-249.1(not)-249.2(review)-252.1(patients)-254.5(in)-249.6(person)-256.2(at)]TJ T* [(follow-up)-454.8(had)-449.9(higher)-448.7(attrition)-450.7(rates)-452.8(compared)-452.1(with)-452(studies)-452(that)]TJ 0 -1.2266 TD [(involved)-189.9(at)-188.8(least)-195(some)-188.5(face-to-face)-193.8(assessment.)-188.3(These)-193.1(studies)-192.8(relied)]TJ 0 -1.2203 TD [(on)-258.3(the)-257.9(techniques)-258.2(of)-254.5(telephone)-257.5(assessment,)-264.2(mail)-252.3(questionnaires,)-260.7(or)]TJ T* [(a)-248.5(combination)-249(to)-249.6(assess)-246.9(outcome.)-252.2(While)-250.2(the)-245.2(overall)-252.3(effort)-245.3(required)]TJ 0 -1.2266 TD [(for)-427.4(both)-425.7(patient)-424.5(and)-424.6(researcher)-433.5(is)-421.5(less)-424.2(for)-427.4(these)-424.9(techniques,)-431.8(the)]TJ 28.0042 35.4462 TD [(patient)-247.4(is)-250.8(likely)-251.8(to)-249.6(gain)-251.1(less)-253.5(from)-247.1(the)-251.6(experience)-254.1(compared)-249.8(with)-249.7(an)]TJ 0 -1.2203 TD [(in-person)-229.7(assessment)-236(and)-234.9(therefore)-229.7(may)-232.1(be)-235.4(less)-228.2(inclined)-234.3(to)-230.7(engage.)]TJ 1.1128 -1.2203 TD [(Again,)-351.7(an)-355.5(unmeasured)-357.5(confounder)-352.9(such)-355.7(as)-356.7(study)-350.5(funding)-357.3(may)]TJ -1.1128 -1.2266 TD [(also)-498.9(inuence)-505.5(attrition)-501.3(rate)-502.7(in)-502.6(this)-500.5(context.)-499.2(Questionnaires)-507.6(are)]TJ 0 -1.2203 TD [(perceived)-201.6(as)-198.6(easy)-193.8(for)-199.8(researchers)-206.6(and)-197(less)-196.5(expensive)-204.1(than)-194.2(reviewing)]TJ T* [(a)-330.7(patient)-329.6(in)-331.8(person.)-328.7(Unfortunately,)-331.8(techniques)-334.1(related)-336.9(to)-325.5(outcome)]TJ 0 -1.2267 TD [(assessment)-198(after)-195(TBI)-195.4(are)-195.7(highly)-188.5(variable)-197.4(in)-192.7(both)-191.8(the)-194.7(assessment)-198(tool)]TJ 0 -1.2203 TD [(used)-393.7(and)-399.3(also)-397.7(the)-403.3(method)-392.7(of)-400(assessment,)]TJ 6.7246 0 0 5.9768 463.6912 302.3999 Tm (30)Tj 8.9663 0 0 8.9663 473.9526 298.4314 Tm [(and)-399.3(consensus)-402.4(is)-396.3(re-)]TJ -18.191 -1.2203 TD [(quired)-227.4(to)-230.7(minimize)-235(the)-226.3(potential)-231.5(bias)-233.3(that)-229.8(varying)-233.2(techniques)-232.9(could)]TJ 0 -1.2266 TD (introduce.)Tj 1.1128 -1.2203 TD .0101 Tc [(We)-301.6(also)-299.2(o)10.1(b)-7.9(served)-299.2(bett)-6.1(er)-301.8(follo)10.1(w)-11.2(-)1.7(u)10.1(p)-305.1(i)-6.1(n)-299.2(stud)10.1(i)-5.6(e)-4.5(s)-300.4(r)1.7(ecruiting)-299.2(i).2(n)-299.2(t).2(h)10.1(e)]TJ -1.1128 -1.2203 TD .011 Tc [(acu)11(t)-4.7(e)-307.1(s)4(etting)-298.3(\()-3.8(h)11(o)-7(spital)-302.4(w)1.9(ard)11(s)-311.7(and)-304.7(i)1.2(n)11(t)-11(ensive)-300.8(care)-307.1(un)11(i)-4.7(t)1.1(s\))-300.9(co)11(m)-4.2(p)-1.2(ared)]TJ 0 -1.2266 TD .0104 Tc [(with)-229.4(tho)10.4(s)-8.8(e)-225.5(r)-4.4(ecru)10.4(i)-11.6(tin)10.4(g)-235.2(i).5(n)-229.4(t).5(he)-225.5(hyp)10.4(e)-10(r)2(ac)]TJ 14.4415 0 TD .0107 Tc [(u)10.7(t)-11.3(e)-225.2(s)-2.6(etting)-229.1(\()2.3(in)-229.1(the)-225.2(p)-1.5(re-ho)10.7(s)-8.5(p)10.7(i)-5(tal)]TJ -14.4415 -1.2203 TD .0104 Tc [(setting)-482.3(o)-1.8(r)-491.2(e)2.2(mergency)-488.6(departm)-5.3(e)2.1(nt\),)-485.7(especially)-488.6(amo)10.4(n)-7.6(g)-488.6(o)-1.8(b)10.4(s)-8.8(erv)10.4(a)-10(-)]TJ T* [(tion)10.3(a)-10.1(l)-347.3(s)3.3(tud)10.3(i)-11.7(es.)-353(T)10.3(h)-7.5(i).4(s)-344.5(m)-5.4(ay)-349.6(b)10.3(e)-357.9(th)10.3(e)-357.9(r)1.9(esult)-347.3(o)10.3(f)-351.7(d)-1.9(ifferent)-347.3(techniq)10.3(u)-7.7(es)-350.8(of)]TJ T* .0098 Tc [(con)9.8(s)-9.4(ent)-227.7(e)1.5(mploy)9.8(e)-10.6(d)-223.7(i)-.1(n)-230(t)-.1(hese)-232.4(two)-223.7(s)-3.5(ett)-6.4(i)-.1(n)9.8(g)-8.2(s.)-227.1(I)-5(n)-223.7(the)-226.1(h)-2.4(y)9.8(p)-8.2(er)-5(acute)-226.1(s)-3.5(etting,)]TJ 0 -1.2266 TD .0105 Tc [(p)10.5(a)-9.9(tients)-293.7(m)1.1(ay)-292.5(be)-288.6(too)-292.5(u)-1.7(n)10.5(s)-8.7(table)-294.9(o)10.5(r)-300.9(u)10.5(n)-7.5(c)2.2(onscio)10.5(u)-7.5(s)-293.7(to)-292.5(g)10.5(i)-5.2(ve)-294.9(con)10.5(s)-8.7(ent)-290.2(a)-4.1(n)10.5(d)]TJ 0 -1.2203 TD .0112 Tc [(relatives)-286.7(may)-285.5(n)-1(o)11.2(t)-295.3(yet)-289.5(b)11.2(e)-293.7(a)-3.4(rou)11.2(n)-6.8(d)-285.5(t)1.3(o)-285.5(p)-1(rovid)11.2(e)-293.7(proxy)-285.5(cons)4.2(en)11.2(t.)-288.9(In)-285.5(ad-)]TJ T* .0104 Tc [(d)10.4(i)-5.3(t)-5.8(i).5(o)10.4(n)-7.6(,)-182.2(time)-187.5(i).5(s)-180(tight,)-182.2(a)2.2(nd)-178.8(research)-185.1(is)-180(frequ)10.4(e)-10(ntly)-178.8(given)-185.1(l).5(o)10.4(w)-10.9(er)-181.4(priority)]TJ 0 -1.2266 TD .0099 Tc [(in)-280.5(such)-280.5(settings.)]TJ 1.1128 -1.2203 TD 0 Tc [(In)-330.4(contrast,)-338.2(in)-338.2(the)-333.8(acute)-337.6(setting,)-337.6(such)-336.8(as)-331.4(the)-340.1(hospital)-334.2(ward,)-338.1(the)]TJ -1.1128 -1.2203 TD [(patient)-335.9(may)-333.3(have)-338(regained)-338.8(capacity)-336.3(to)-338.2(consent)-335.4(or)-336.7(may)-333.3(have)-338(rela-)]TJ 0 -1.2266 TD [(tives)-300.1(available)-295.5(who)-299(are)-303.1(aware)-295.2(of)-298.8(the)-302.2(patients)-300.8(attitudes)-295.9(toward)-300.3(re-)]TJ 0 -1.2203 TD [(search)-330.6(and)-329.7(provide)-328.1(proxy)-329(consent.)-332(Studies)-329.3(recruiting)-333.4(in)-331.8(the)-327.4(acute)]TJ T* [(setting)-189.3(and)-190.6(beyond)-182.9(may)-194.2(inadvertently)-190.3(pre-select)-189.9(a)-191.6(cohort)-189.5(of)-185(patients)]TJ T* [(who)-261.1(are)-265.2(more)-265.8(research)-265.1(interested.)-267.7(Further,)-262.6(the)-264.2(majority)-269.6(of)-260.9(patients)]TJ 0 -1.2266 TD [(with)-319.2(TBI)-328.1(recruited)-325.9(in)-319.2(the)-321.1(emergency)-327.6(department)-326.4(\(hyperacute)-323.4(set-)]TJ 0 -1.2203 TD [(ting\))-324.3(would)-327.4(not)-325(be)-323.9(admitted)-326.3(to)-325.5(hospital.)-330.8(In)-324.1(contrast,)-325.5(admitted)-332.7(pa-)]TJ T* [(tients)-626.1(\(acute)-630.6(setting\))-627.7(will)-626.7(be)-627.4(more)-626.2(likely)-631.2(to)-629(have)-622.5(persistent)]TJ 0 -1.2266 TD [(symptoms,)-240.1(receive)-246.8(care)-241.8(they)-244.8(may)-238.4(remember,)-246.2(and)-241.2(had)-241.2(time)-239.7(to)-243.3(build)]TJ ET q 324.929 0 0 267.987 142.583 464.258 cm /Im3 Do Q BT /F5 1 Tf 8.9663 0 0 8.9663 59.7543 447.4771 Tm [(FIG.)-258.9(3.)]TJ /F4 1 Tf 4.0403 0 TD [(Illustration)-257(of)-254.5(the)-251.6(association)-256.6(between)-257.8(study)-255.7(design)-257.6(factors)-258.4(and)-253.9(patient)-253.8(attrition,)-257.6(based)-256.5(on)-251.9(148)-257.8(studies)-256(of)-254.5(traumatic)-255(brain)-253.2(injury)]TJ -4.0403 -1.1128 TD [(using)-281(a)-286.5(logistic)-281.3(regression)-283.4(model.)-282.3(The)-285.3(y-axis)-279.2(shows)-281.4(the)-283.2(odds)-283.8(of)-279.8(attrition)-286.3(based)-281.8(on)-277.2(time)-283.9(since)-285.8(injury)-279.6(and)-285.5(total)-277.6(number)-283.8(of)-279.8(follow-up)-284(time)]TJ 0 -1.1065 TD [(points.)-274.8(Time)-267.1(since)-273.2(injury)-267(refers)-270.1(to)-268.6(the)-270.5(total)-271.3(study)-268.3(durationi.e.,)-269(the)-270.5(time)-271.3(between)-270.4(injury)-273.3(and)-266.5(the)-270.5(nal)-268.6(follow-up.)-274.3(Thus,)-267.5(two)-271.4(studies)-268.7(may)]TJ 0 -1.1128 TD [(run)-336.3(for)-332.5(the)-333.8(same)-336.4(duration)-331.6(\(x-axis\),)-336.9(but)-337.7(one)-329.7(study)-337.9(may)-333.3(follow)-333.5(patients)-336.7(up)-334.1(more)-329.1(frequently)-335.7(than)-339.6(the)-333.8(other)-329.1(\(lines)-340.1(and)-329.7(symbols\).)]TJ /F1 1 Tf 0 37.0396 TD [(STUDY)-335.9(DESIGN)-336.8(FEATURES)-342.3(ASSOCIATED)-333.4(WITH)-335.9(ATTRITION)-23740.1(1851)]TJ ET endstream endobj 68 0 obj <>stream AdobedC       / s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz?Nlٳf͛6lٳg)/mOk3y.cⶵ#Rfj.H?(ឱ/+jڥĸ#"=/_hZrۀE5=条hzfذ3;jڕޥ<ۖPA۳ R{LP:niw@\ 14.dv޲ԙ% z>bGK^ lT ,z*v>9??SWԴաhX[j_ yf͛6lٳf͛6lٳf͛6lٳf͛6lٳͶG?8\kOjMmhn`f(.FشC|c]ZIjeCF*.DZ힋Bk =xReucjR:>n򯛴̯2Z.gz"]CLh(ˆU\*}o+O#i^_gkBH ~F T -hd5uΆKlaGPø}o.z7g`Q"[H# v%1o,Ϛߙ4}SY.k3Co8<"ߙhZO~?#6IAayX2ԧy?a.4O,P\XjM¨H+]Ej禢.bC ʎ@t7)?&8"OŒ??#ha[A{Z[ߤj.D哔o3Zy,~v~V+MR$1u"|O_3^ri*I[,LW*jzOOuOش;->Vѡz5Ϳյ!u=昶sGMKh$ *nPp9~O:Ο^Z΃" L9#Z~87Lm8\_JڍPQc1R{dBƝ?:U5&CfPK,ldMOˍ>ΞZ4w-k{{[}'I% ژ/u9k^I[7 cN%vW7܀Vq{]?FF|Xi)]fE{V$J +\yO] MB.:ˡjMI}So}:1KizWVy;xVEDk,Ge zkdK2^>gԼ{ڴz{ ċB-z?䷓l>rֵ+Z:>_Jkr:ʾ?'t3j6:֙]ykZt_VմͿD2|-yGͷgWԵ !kIzDO7N4 lιwj-Ο}CstdaCӡ9j"L|׬>OԶҏ@5HOJ j_Vy[F:Nw=W;^<6y$3y.+EU)/T)qƝS$i$m-N'Km-m!֗}#O?Тt}BC{`36zǝXK21oJ0n`-?DUy͐J#EH|TSZֽ 󍱋q?5poGLGWe tοaagDZZư›*"*s6~ICy]=_PEMRM9ri u:3B.n0k$Mu,|D 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:/7sPwnO֫MNȭ}'٦,O,v~_K ylrz؉%KUEiykMI5+=>U6Ǧ܆=5;S"?$ٍ+E֒4˳ۉ$<BJ8}-#NQZMf>uf`g-Ff&j 4 4t?,t2CGpʼngJ,]W67uy4ss{bђ9BT 2tXNk7wQE!0?7 %Mt*Ohm-|j$]>)'ϮV>γ9;ήW׷Vk*$TMձ׹dzʴ;l?+C{ٳ۲ڶٳҠҘ溏ȯˢ᰹ǰ򸰿ܲۛ)OԷC:9m?'.>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(a)-191.6(relationship)-195.9(with)-192.8(the)-194.7(research)-195.5(and)-197(clinical)-196.5(team)-193.8(and)-190.6(are)-195.7(thus)-192.9(likely)]TJ 0 -1.2203 TD [(more)-284.8(invested)-282(into)-278(the)-283.2(research)-284(project.)]TJ 1.1128 -1.2266 TD [(Our)-270(result)-270.6(thus)-268.8(likely)-264.5(reects)-275.8(an)-267(underlying)-267.4(selection)-275.4(bias.)-267.8(This)]TJ -1.1128 -1.2203 TD [(highlights)-284.3(the)-276.9(need)-287.4(for)-275.6(keeping)-283.6(a)-280.1(recruitment)-288.2(log)-280.8(or)-279.8(registry)-284.8(of)-279.8(all)]TJ T* [(patients)-355.6(approached)-355.2(for)-357.8(the)-352.7(study,)-353.4(including)-351.5(those)-359.3(who)-349.6(declined.)]TJ 0 -1.2266 TD [(Comparing)-398.6(patients)-399.9(who)-400.2(do)-397.4(return)-400.7(to)-395.1(follow-up)-397.9(with)-401.4(those)-397.2(who)]TJ 0 -1.2203 TD [(were)-356.6(recruited)-357.5(but)-356.6(dropped)-355.7(out)-356.6(as)-350.4(well)-359.6(as)-356.7(those)-352.9(who)-355.9(were)-356.5(never)]TJ T* [(recruited,)-309.9(could)-307.5(then)-308(provide)-309.1(an)-311.3(excellent)-308.2(guide)-307.5(on)-308.8(the)-308.5(generaliz-)]TJ 0 -1.2266 TD [(ability)-280.6(of)-279.8(study)-281(results.)]TJ 1.1128 -1.2203 TD [(This)-382.4(has)-387.8(both)-387.8(strengths)-384.1(and)-386.7(limitations.)-389.2(Strengths)-387.8(include)-382.5(the)]TJ -1.1128 -1.2203 TD [(sample)-219.3(size)-216.7(which,)-212.6(with)-218.1(148)-213.5(studies)-211.7(and)-215.9(more)-215.3(than)-213.1(70,000)-215.5(patients,)]TJ T* [(is)-314.1(comparatively)-312.4(large,)-315.4(as)-312.4(well)-315.3(as)-312.5(the)-314.8(careful)-316.6(handling)-310.1(of)-311.5(missing)]TJ 0 -1.2266 TD [(data.)-300.7(This)-300.2(review)-302.7(was)-302.6(based)-300.8(on)-302.5(an)-298.6(earlier)-301.6(review)-302.7(that)-299.4(used)-305.2(exclu-)]TJ 0 -1.2203 TD [(sively)-198.4(GOSE)-199.1(as)-198.6(an)-197.4(outcome)-192.3(measure)-200.8(for)-199.8(TBI,)-198.3(but)-192.2(multiple)-201.5(outcome)]TJ T* [(scales)-206.7(for)-206.1(TBI)-208(exist,)-201.8(which)-209.6(themselves)-206(could)-206.3(inuence)-202(attrition)-210.4(rate)]TJ 0 -1.2266 TD [(differently)-202.7(from)-202.8(GOSE.)-202(This)-205.4(is)-200.2(true)-203.1(for)-199.8(mild)-205.6(TBI)-201.7(where)-204.3(GOSE)-199.1(may)]TJ 0 -1.2203 TD [(lack)-285.1(the)-276.9(sensitivity)-285.1(to)-281.3(detect)-284.2(subtle)-280.6(symptomatology)-281.5(and)-279.2(may)-282.7(also)]TJ T* [(explain)-256.1(the)-251.6(relatively)-255(low)-252.5(representation)-261.6(of)-248.2(mild)-256.2(TBI)-252.3(in)-256(our)-247.7(cohort)]TJ 0 -1.2266 TD [(despite)-282.5(this)-279.2(being)-282.2(the)-283.2(more)-278.5(prevalent)-285.4(severity)-278.3(subtype.)]TJ 1.1128 -1.2203 TD [(Further,)-332.2(the)-340.1(goal)-333.3(of)-336.7(this)-336.1(analysis)-340.1(was)-334.2(not)-331.3(to)-338.2(predict)-334.5(patient)-342.3(at-)]TJ -1.1128 -1.2203 TD [(trition,)-245.8(but)-242.8(to)-243.3(understand)-248(which)-241.2(study)-243(design)-245(factors)-245.8(are)-246.2(associated)]TJ T* [(with)-287.6(it.)-288.2(Our)-282.7(model)-285.7(therefore)-292.9(serves)-285.1(to)-287.6(highlight)-289.9(which)-285.5(design)-289.2(fac-)]TJ 0 -1.2266 TD [(tors)-233.5(should)-229.9(be)-229.1(considered)-237.8(when)-231.4(planning)-227.9(a)-229.6(TBI)-233.3(study,)-233.3(rather)-232.4(than)-232.1(a)]TJ 0 -1.2203 TD [(tool)-328.6(to)-331.8(calculate)-329.6(anticipated)-336.5(follow-up)-328.3(rates.)-329.3(Importantly,)-330.6(as)-331.4(with)]TJ T* [(all)-489.5(observations,)-482.8(association)-490.5(does)-488.5(not)-483.1(equate)-488.9(to)-483.6(causation,)-489.2(and)]TJ 0 -1.2266 TD [(adopting)-259.5(a)-254.8(specic)-260.5(study)-262(design)-257.6(feature)-259.7(does)-260.9(not)-255.5(guarantee)-258.5(patient)]TJ 0 -1.2203 TD [(retention.)-226.7(In)-229.2(addition,)-228.5(there)-230.3(are)-227.3(aspects)-231.5(of)-222.9(the)-232.6(study)-224.1(design)-226(\(such)-231.4(as)]TJ T* [(site)-287.9(experience)-292(and)-285.5(patient)-285.4(incentives\))-289.6(that)-286.7(may)-282.7(contribute)-286.5(to)-287.6(suc-)]TJ 0 -1.2266 TD [(cessful)-351.9(follow-up,)-350.2(but)-350.3(that)-343.6(could)-351.8(not)-350.3(be)-349.2(extracted)-351(retrospectively)]TJ 0 -1.2203 TD [(from)-278.7(published)-285.5(manuscripts.)-284.5(These)-281.6(would)-283.1(be)-279.6(important)-281.8(to)-281.3(include)]TJ T* [(in)-281.3(future)-280.6(prospective)-285.6(studies)-281.3(of)-279.8(patient)-279(attrition.)]TJ 1.1128 -1.2266 TD [(Finally,)-284.4(as)-293.5(well)-290(as)-287.2(the)-283.2(features)-292(described)-295.2(here,)-286.6(there)-287.2(are)-290.5(factors)]TJ -1.1128 -1.2203 TD [(beyond)-220.8(the)-213.6(study)-217.7(design)-219.7(\(thus)-220.3(beyond)-214.5(our)-216.1(model\))-218.3(that)-217.2(inuence)-220.9(the)]TJ T* [(success)-329.9(of)-324.1(follow-up.)-318.6(In)-324.1(our)-323.6(experience,)-332.9(a)-324.4(common)-322.7(but)-318.7(often)-329.1(un-)]TJ T* [(measurable)-439.8(cause)-442.3(of)-437.9(loss)-440.7(to)-439.3(follow-up)-435.8(and)-443.6(inability)-435.4(to)-439.3(perform)]TJ 0 -1.2266 TD [(specic)-424.9(outcome)-426.3(measures)-422.8(are)-423.3(extremes)-425.7(of)-418.9(functional)-425.6(outcome.)]TJ 0 -1.2203 TD [(Patients)-417.4(with)-420.4(good)-415.4(outcomes)-414.3(who)-419.2(recover)-420(completely)-416.3(may)-415.5(lose)]TJ T* [(motivation)-472.4(to)-464.6(continue)-470.5(in)-470.9(research)-467.4(while)-472.9(those)-466.8(with)-471(very)-471(poor)]TJ 0 -1.2266 TD [(outcomes)-212(may)-213.1(be)-210.1(unable)-208.3(to)-211.7(return)-211.1(because)-216.1(of)-210.3(dependency)-207.1(on)-214(carers)]TJ 0 -1.2203 TD [(to)-433(attend)-439.9(or)-437.9(complete)-438.6(follow-up)-435.8(assessments.)-441.9(Efforts)-433.1(should)-438.6(be)]TJ T* [(made)-253(to)-256(obtain)-247.8(follow-up)-258.8(data)-253.5(from)-253.4(all)-249.3(patients)-254.4(and)-253.9(in)-256(the)-251.6(event)-253(of)]TJ 0 -1.2266 TD [(its)-279.6(absence,)-282.2(determine)-288.9(the)-276.9(reasons)-284.6(for)-282(loss)-276.3(to)-281.3(follow-up.)]TJ /F1 1 Tf 0 -2.4406 TD (Conclusions)Tj /F4 1 Tf 1.1128 -1.8336 TD [(We)-540.8(highlight)-542.8(study)-546.5(design)-542.1(features)-544.9(associated)-546.3(with)-546.8(loss)-541.9(to)]TJ -1.1128 -1.2203 TD [(follow-up)-233.5(in)-224.3(longitudinal)-231.6(TBI)-227(studies.)-233.6(When)-230(planning)-227.9(a)-229.5(TBI)-227(study,)]TJ 0 -1.2266 TD [(we)-264(suggest)-258.3(considering)-264.2(how)-261.1(the)-264.2(study)-262(design)-263.9(may)-257.4(relate)-267.9(to)-256(patient)]TJ 0 -1.2203 TD [(attrition.)-226(Particular)-226.9(thought)-225.9(should)-223.6(be)-229.1(given)-225.3(to)-224.3(how)-223.1(often)-227.9(and)-222.3(when)]TJ T* [(patients)-191.2(are)-195.7(asked)-193.3(to)-192.7(return,)-188.7(the)-194.7(method)-190.4(of)-191.3(outcome)-192.3(collection)-195.5(in)-186.4(the)]TJ 0 -1.2266 TD [(case)-366.9(of)-368.4(GOSE,)-366.4(and)-361.4(timing)-366.7(of)-368.4(patient)-367.6(recruitment.)-367(A)-363.2(balance)-370.7(be-)]TJ 0 -1.2203 TD [(tween)-439.7(focusing)-442.6(all)-439(resources)-446.7(onto)-438.3(follow-up)-442.1(and)-437.2(answering)-441.5(the)]TJ T* [(specic)-228.9(study)-230.4(question)-229(has)-229.8(to)-230.7(be)-229.1(managed)-228.7(carefully,)-234(however.)-231.5(This)]TJ 0 -1.2266 TD 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[(\(2017\).)-548.1(Traumati)13.6(c)-556(brain)-549.5(injury:)-546.3(integrated)-549.7(approaches)-544.4(to)-549.2(improve)]TJ T* [(preventio)11.9(n,)-324.1(clinical)-314.2(care,)-323.8(and)-317.1(research.)-316.1(Lancet)-315.6(Neurol.)-321.3(16,)-314.9(9871048.)]TJ -1.2448 -1.1239 TD [(5.)-494.8(McMillan,)-352.3(T.,)-365.5(Wilson,)-355.7(L.,)-365.5(Ponsford,)-350.9(J.,)-366.9(Levin,)-360(H.,)-361.1(Teasdale,)-357.4(G.,)-361.1(and)]TJ 1.2448 -1.1239 TD [(Bond,)-393.7(M.)-394.3(\(2016\).)-391.6(The)-395.1(Glasgow)-391.7(Outcome)-394.7(Scale40)-392.7(years)-391.8(of)-397.6(appli-)]TJ T* [(cation)-325.2(and)-331.3(renement.)-327.4(Nat.)-324.1(Rev.)-335(Neurol.)-321.3(12,)-336.2(477485)14.5(.)]TJ -1.2448 -1.131 TD -.0178 Tc [(6)-17.8(.)-512.6(Kre)-17.8(l)13.1(lman,)-408(J)-2.7(.W)4.5(.,)-408(Ko)5.6(lakowsk)5.6(y-Ha)-17.8(y)18.7(n)-1.5(er)]TJ 15.9606 0 TD -.0183 Tc [(,)-395.6(S).2(.A.,)-408.5(Spielma)-18.3(n)18.2(,)-415.6(L)-1.8(.,)-415.6(Dijkers,)-415.6(M)6(.)-3(,)]TJ -14.7158 -1.1239 TD .3475 Tc [(H)368.4(a)367.7(m)367.4(m)347.5(o)383.7(n)363.8(d)370.9(,)0(F)366(.)362.8(M)364.7(.)369.9(,B)366.2(o)363.8(g)370.9(n)363.8(e)367.7(r)347.5(,)12.9(J)369.7(.)362.8(,H)368.4(a)367.7(r)347.5(t)378.2(,)0(T)371.1(.)362.8(,C)366.2(a)367.7(n)363.8(t)365.3(o)370.9(r)347.5(,)12.9(J)369.7(.)362.8(B)366.2(.)369.9(,a)347.5(n)384(d)1(T)364(s)362.6(a)367.7(o)363.8(u)370.9(s)362.6(i)365.3(d)370.9(e)347.5(s)382.8(,T)364(.)]TJ T* -.0179 Tc [(\(20)5.5(14\).)-287.2(P).6(redictors)-287.3(o)5.5(f)-289.5(f)2.1(ollo)5.5(w-up)-279(c)-17.9(o)18.6(mplete)-17.9(n)18.6(e)-17.9(s)17.4(s)-287.3(in)-286.1(lo)5.5(ngitu)5.5(din)5.5(a)-17.9(l)-271.5(r)2.1(e)-17.9(s)17.4(ea)-17.9(r)15.2(c)2.3(h)-286.1(o)-1.6(n)]TJ T* -.0181 Tc [(traumatic)-310.9(brain)-314.8(i)-.3(n)5.3(j)-.3(ury:)-306.2(nd)5.3(i)-.3(ngs)-308.8(from)-304.1(t)-.3(he)-310.9(Na)-18.1(t)12.8(i)-.3(o)5.3(n)-1.8(al)-313.3(Institute)-303.8(on)-307.7(Disability)]TJ T* -.0183 Tc [(and)-364.8(R).4(e)-18.3(h)18.2(a)-18.3(b)18.2(ilitation)-364.8(R).4(e)-18.3(s)17(e)-18.3(a)15(rc)-18.3(h)-351.7(t)-.5(ra)-18.3(u)18.2(m)1.6(a)-18.3(t)12.6(ic)-368(brain)-371.9(i)-.5(n)5.1(j)-.5(ury)-371.9(m)1.6(o)5.1(d)-2(el)-370.4(sy)5.1(stems)-373.1(p)5.1(r)-18.3(o)18(-)]TJ T* -.0173 Tc [(g)6.1(r)-17.3(a)15.8(m)2.6(.)-336.3(A)3.6(rch.)-329.2(Phys)4.9(.)-336.3(M)7(e)-17.3(d)19.2(.)-336.3(R)1.4(ehabil.)-329.2(95)6.1(,)-336.3(6)6.1(33)6.1(641)6.1(.)]TJ -1.2448 -1.1239 TD 0 Tc [(7.)-494.8(Zelnick,)-236.6(L.R.,)-239.1(Morrison,)-236.9(L.J.,)-235.6(Devlin,)-238.2(S.M.,)-238.6(Bulger,)-238.1(E.M.,)-240.6(Brasel,)-235.4(K.J.,)]TJ 1.2448 -1.131 TD [(Sheehan,)-454.2(K.,)-467.8(Minei,)-457.3(J.P.,)-468.3(Kerby,)-460(J.D.,)-458.8(Tisherman,)-455.4(S.A.,)-462.5(Rizoli,)-459.4(S.,)]TJ 0 -1.1239 TD [(Karmy-J)11.5(ones,)-436.1(R.,)-441.6(van)-438(Heest,)-438.2(R.,)-434.5(Newgard,)-433.1(C.D.,)-433.9(and)-438(Resuscitation)]TJ T* [(Outcomes)-557.4(Consortiu)12.4(m)-570.5(Investigat)14.3(ors.)-566.4(\(2014\).)-555.2(Addressing)-558.3(the)-564.5(chal-)]TJ T* [(lenges)-335.1(of)-340.7(obtaining)-328.5(functional)-333.1(outcomes)-334.4(in)-335.8(traumatic)-334.7(brain)-336.1(injury)-336.4(re-)]TJ T* [(search:)-759.3(missing)-763.7(data)-764.8(patterns,)-758.5(timing)-761.9(of)-767.5(follow-up)12.4(,)-767.2(and)-765.2(three)]TJ T* [(prognost)13.5(ic)-331.9(models.)-327.2(J.)-332.4(Neurotrauma)-325.3(31,)-329.1(10291038.)]TJ -1.2448 -1.131 TD [(8.)-494.8(Richter,)-451.2(S.,)-456(Stevenson,)-453.6(S.,)-456(Newman,)-449.6(T.,)-458(Wilson,)-455.3(L.,)-450.9(Menon,)-453.2(D.K.,)]TJ 1.2448 -1.1239 TD [(Maas,)-637.5(A.I.R.,)-640.4(Nieboer,)-635.4(D.,)-645.6(Lingsma,)-630.8(H.,)-645.7(Steyerberg,)-631.1(E.W.,)-641(and)]TJ T* [(Newcom)11.7(be,)-375(V.F.)-363.9(\(2019\).)-363.2(Handling)-363.1(of)-369.1(missing)-358.2(outcome)-363.8(data)-373.6(in)-364.2(trau-)]TJ T* 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