我要吃瓜

Citation

Coleman T, Clark M, Welch C, Whitemore R, Leonardi-Bee J, Cooper S, Hewitt C, Jones M, Sutton S, Watson J, Daykin K, Ussher M, Parrott S & Naughton F (2022) Effectiveness of offering tailored text message, self-help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial and meta-analysis. Addiction, 117 (4), pp. 1079-1094. https://doi.org/10.1111/add.15715

Abstract
Aims To test efficacy of “MiQuit’, a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy. Design Multicentre, open, two-arm, parallel-group, superiority randomised controlled trial (RCT) and a Trial Sequential Analysis (TSA) meta-analysis combining trial findings with two previous ones. Setting 24 English hospital antenatal clinics. Participants 1002 pregnant women who were ≥16 years old, were ≤ 25 weeks gestation, and smoked ≥ one daily cigarette and accepted information on cessation with no requirement to set quit dates. Interventions UC or UC plus ‘MiQuit’: 12 weeks of tailored, smoking cessation text messages focussed on inducing and aiding cessation. Measurements Primary outcome: biochemically-validated cessation between 4 weeks after randomisation and late pregnancy. Secondary outcomes: shorter and non-validated abstinence periods, pregnancy outcomes and incremental cost-effectiveness ratios. Findings RCT: cessation was 5.19% (26/501) and 4.59% (23/501) in MiQuit and UC groups [adjusted odds ratio (adj OR) for quitting with MiQuit versus UC, 95% confidence interval (CI), 1.15 (0.65 to 2.04)]; other abstinence findings were similar, with higher point estimates. Primary outcome ascertainment was 61.7% (309) and 67.3% (337) in MiQuit and UC groups with 71.1% (54/76) and 69.5% (41/59) abstinence validation rates, respectively. Pregnancy outcomes were similar and the incremental cost per Quality-Adjusted Life Year was -?1,118 (95% CI -?4,806 to ?1,911). More MiQuit group women reported making at least one quit attempt (adj OR (95% CI) for making an attempt, 1.50 (1.07 to 2.09). TSA Meta-analysis: This found no significant difference in prolonged abstinence between MiQuit and UC (pooled OR 1.49, adjusted 95% CI 0.62 to 3.60). Conclusions Irrespective of whether they want to try quitting, when offered a tailored, self-help, text message stop smoking programme for pregnancy (MiQuit) as an adjunct to usual care, pregnant women are not more likely to stop smoking until childbirth but they report more attempts at stopping smoking

Keywords
pregnancy; self-help; smoking cessation; text messaging

Journal
Addiction: Volume 117, Issue 4

• Published version
• Supplementary material