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Citation

Turner JE, Aldred S, Witard O, Drayson MT, Moss PM & Bosch JA (2010) Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain, Behavior, and Immunity, 24 (8), pp. 1362-1370. https://doi.org/10.1016/j.bbi.2010.07.239

Abstract
Exercise induces mobilisation of CD8+ T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise. Fourteen males (Mean age 35, SD ± 14 yrs), half of whom were CMV seropositive (CMV+), ran on a treadmill for 60 min at 80% V_ O2 max. Blood was collected at baseline, during the final minute of exercise, and 15 min and 60 min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28. The results confirmed that CD8TLswith an effector-memory phenotype (CD27CD28CD45RA+/) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60 min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV+ individuals. This effect appeared specific to CD8TLs, and was not seen for CD4+ T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV+ participants. This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.

Keywords
Cytomegalovirus; CD8(+) T lymphocytes; Memory lymphocytes; Lymphocytosis; Lymphocytopenia; Immune surveillance; Migration; Exercise; Stress; Human

Journal
Brain, Behavior, and Immunity: Volume 24, Issue 8