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Article

Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

Details

Citation

Phillips AC, Carroll D, Gale CR, Lord JM, Arlt W & Batty GD (2010) Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study. European Journal of Endocrinology, 162 (5), pp. 919-923. https://doi.org/10.1530/eje-09-1078

Abstract
Objectives: The aim of these analyses was to examine the association of cortisol, DHEAS and the cortisol:DHEAS ratio with the metabolic syndrome (MetS) and its components. Design: The analyses were cross-sectional. Methods: Participants were 4255 Vietnam era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. MetS was ascertained from data on body mass index; fasting blood glucose or a diagnosis of diabetes; blood pressure or a diagnosis of hypertension; high-density lipoprotein cholesterol; and triglyceride levels. Contemporary morning fasted cortisol and DHEAS concentrations were determined. The outcomes were MetS and its components. Analysis was by logistic regression, first adjusting for age and then additionally for an array of candidate confounders. Results: Cortisol, although not in the fully adjusted analysis, and DHEAS were both related to MetS. Whereas high cortisol concentrations were associated with an increased risk of MetS, high DHEAS concentrations appeared protective. By far, the strongest associations with MetS were observed for the cortisol:DHEAS ratio; the higher the ratio, the greater the risk of having MetS. The ratio was also significantly related to four of the five MetS components. Conclusions: The cortisol:DHEAS ratio is positively associated with MetS. Prospective analyses are needed to help untangle direction of causality, but this study suggests that the cortisol:DHEAS ratio is worthy of further study in this and other health contexts. European Journal of Endocrinology 162 919-923

Keywords
Endocrinology, Diabetes and Metabolism; Endocrinology; General Medicine

Journal
European Journal of Endocrinology: Volume 162, Issue 5

StatusPublished
Funders
Publication date31/05/2010
Publication date online31/05/2010
Date accepted by journal17/02/2010
URL
PublisherBioscientifica
ISSN0804-4643
eISSN1479-683X

People (1)

Professor Anna Whittaker

Professor Anna Whittaker

Professor of Behavioural Medicine, Sport