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Citation

Anokye N, Fox-Rushby J, Sanghera S, Cook DG, Limb E, Furness C, Kerry SM, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, Dewilde S & Harris T (2018) Short-term and long-term cost-effectiveness of a pedometer-based exercise intervention in primary care: A within-trial analysis and beyond-trial modelling. BMJ Open, 8 (10), Art. No.: e021978. https://doi.org/10.1136/bmjopen-2018-021978

Abstract
Objectives A short-term and long-term cost-effectiveness analysis (CEA) of two pedometer-based walking interventions compared with usual care. Design (A) Short-term CEA: Parallel three-arm cluster randomised trial randomised by household. (B) Long-term CEA: Markov decision model. Setting Seven primary care practices in South London, UK. Participants (A) Short-term CEA: 1023 people (922 households) aged 45-75 years without physical activity (PA) contraindications. (b) Long-term CEA: A cohort of 100 000 people aged 59-88 years. Interventions Pedometers, 12-week walking programmes and PA diaries delivered by post or through three PA consultations with practice nurses. Primary and secondary outcome measures Accelerometer-measured change (baseline to 12 months) in average daily step count and time in 10 min bouts of moderate to vigorous PA (MVPA), and EQ-5D-5L quality-adjusted life-years (QALY). Methods Resource use costs (?2013/2014) from a National Health Service perspective, presented as incremental cost-effectiveness ratios for each outcome over a 1-year and lifetime horizon, with cost-effectiveness acceptability curves and willingness to pay per QALY. Deterministic and probabilistic sensitivity analyses evaluate uncertainty. Results (A) Short-term CEA: At 12 months, incremental cost was ?3.61 (?109)/min in ≥10 min MVPA bouts for nurse support compared with control (postal group). At ?20 000/QALY, the postal group had a 50% chance of being cost saving compared with control. (B) Long-term CEA: The postal group had more QALYs (+759 QALYs, 95% CI 400 to 1247) and lower costs (-?11 million, 95% CI -12 to -10) than control and nurse groups, resulting in an incremental net monetary benefit of ?26 million per 100 000 population. Results were sensitive to reporting serious adverse events, excluding health service use, and including all participant costs. Conclusions Postal delivery of a pedometer intervention in primary care is cost-effective long term and has a 50% chance of being cost-effective, through resource savings, within 1 year. Further research should ascertain maintenance of the higher levels of PA, and its impact on quality of life and health service use. ? Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ.

Keywords
accelerometry; adult; aged; Article; cohort analysis; consultation; controlled study; cost effectiveness analysis; EQ-5D-5L utility score; exercise; health care delivery; health care utilization; health economics; human; major clinical study; multicenter study; parallel design; pedometry; primary medical care; quality adjusted life year; quality of life assessment; randomized controlled trial; step count; walking; actimetry; activity tracker; age; clinical trial; cost benefit analysis; demography; economics; England; female; health promotion; male; Markov chain; mental health; middle aged; nurse; organization and management; postal mail; primary health care; program evaluation; self concept; sex factor; socioeconomics; very elderly, Actigraphy; Age Factors; Aged; Aged, 80 and over; Cost-Benefit Analysis; Female; Fitness Trackers; Health Promotion; Humans; London; Male; Markov Chains; Mental Health; Middle Aged; Nurses; Postal Service; Primary Health Care; Program Evaluation; Quality-Adjusted Life Years; Residence Characteristics; Self Efficacy; Sex Factors; Socioeconomic Factors; Walking

Journal
BMJ Open: Volume 8, Issue 10

• Published version