我要吃瓜

Citation

Ormsby MJ, Johnson SA, Carpena N, Meikle LM, Goldstone RJ, McIntosh A, Wessel HM, Hulme HE, McConnachie CC, Connolly JPR, Roe AJ, Hasson C, Boyd J, Fitzgerald E & Gerasimidis K (2020) Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. Cell Reports, 30 (7), pp. 2297-2305.e5. https://doi.org/10.1016/J.CELREP.2020.01.078

Abstract
The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).

Keywords
Crohn's disease; adherent-invasive E. coli; propionic acid; short chain fatty acid

Notes
Additional co-authors: Douglas Morrison, Georgina L. Hold, Richard Hansen, Daniel Walker, David G.E. Smith, Daniel M. Wall

Journal
Cell Reports: Volume 30, Issue 7

• Published version