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Citation

Weidmann M, Faye O, Faye O, Abd El Wahed A, Patel P, Batejat C, Manugerra JC, Adjami A, Niedrig M, Hufert FT & Sall AA (2018) Development of mobile laboratory for viral hemorrhagic fever detection in Africa. Journal of Infectious Diseases, 218 (10), pp. 1622-1630. https://doi.org/10.1093/infdis/jiy362

Abstract
Background In order to enable local response to viral haemorrhagic fever outbreaks a mobile laboratory transportable on commercial flights was developed. Methodology The development progressed from use of mobile real time RT-PCR to mobile Recombinase Polymerase Amplification (RT-RPA). The various stages of the mobile laboratory development are described. Results A brief overview of its deployments, which culminated in the first on site detection of Ebola virus disease (EVD) in March 2014 and a successful use in a campaign to roll back EVD cases in Conakry in the West-Africa Ebola virus outbreak are described. Conclusion The developed mobile laboratory successfully enabled local teams to perform rapid viral haemorrhagic fever disgnostics.

Keywords
Viral haemorragic fever virus; Recombinase polymerase amplification; SmartCycler; Mobile laboratory; Ebola virus disease; point of care; laboratory suitcase

Journal
Journal of Infectious Diseases: Volume 218, Issue 10

• Published version