我要吃瓜

Professor Simon MacKenzie

Professor & Head of Inst of Aquaculture

Institute of Aquaculture Pathfoot Building, 我要吃瓜, Stirling, FK9 4LA

Professor Simon MacKenzie

Contact details

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http://www.stir.ac.uk/people/simonmackenzie

Research (7)

My interests lie in fish health integrating behaviour, immunity and bioinformatics toward improving health in aquaculture. I approach this with an integrative suite of methods both experimental and theoretical spanning across the fields of behavioural ecology, evolution and immunity. This is underpinned by the application of state of the art -omics techniques including proteomics, transcriptome and microbiome and WGS supported within a proven bioinformatic strategy for assembly, annotation, analysis and network modelling. Throughout my career to date my major academic interest has become to explore how immunity has evolved and recently how environmental conditions, particularly temperature, modulate the plasticity of the immune response.

Projects

Effect of swimming training in smolt; A Basic Study
PI: Professor Amaya Albalat
Funded by: The Research Council of Norway
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Vaccines against AMR in Aquaculture
PI: Professor Margaret Crumlish
Funded by: International Development Research Centre
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ROBUST-SMOLT Impact of Early Life History in Freshwater Recirculation Aquaculture Systems on A. Salmon Robustness and Susceptibility to Disease at Sea
PI: Professor Herve Migaud
Funded by: Biotechnology and Biological Sciences Research Council
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Impact of Net Cleaning and Sea Lice treatment upon Gill Health in Salmon
PI: Professor Simon MacKenzie
Funded by: The Norwegian Seafood Research Fund
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Development of a full season production protocol for rainbow trout
PI: Professor Simon MacKenzie
Funded by: Norwegian Research Council
–

Technical considerations of closed containment sea pen production for some life stages of salmonids
PI:
Funded by: Scottish Aquaculture Research Forum
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Health and welfare of lumpfish in hatchery production and deployed in Scottish salmon cages
PI: Professor Sonia Rey Planellas
Funded by: Scottish Aquaculture Innovation Centre
–

Outputs (118)

Outputs

Showing 100 of 118 — See all 118 outputs

Article

Changes in circulating insulin-like growth factor-1 and its binding proteins in yearling rainbow trout during spring under natural and manipulated photoperiods and their relationships with gill Na+, K+-ATPase and body size

Cui W, Takahashi E, Morro B, Balseiro P, Albalat A, Pedrosa C, Mackenzie S, Nilsen TO, Sveier H, Ebbesson LO, Handeland SO & Shimizu M (2022) Changes in circulating insulin-like growth factor-1 and its binding proteins in yearling rainbow trout during spring under natural and manipulated photoperiods and their relationships with gill Na+, K+-ATPase and body size. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 268, Art. No.: 111205. https://doi.org/10.1016/j.cbpa.2022.111205

Article

Stressor controllability modulates the stress response in fish

Cerqueira M, Millot S, Silva T, Félix AS, Castanheira MF, Rey S, MacKenzie S, Oliveira GA, Oliveira CCV & Oliveira RF (2021) Stressor controllability modulates the stress response in fish. BMC Neuroscience, 22 (1), Art. No.: 48. https://doi.org/10.1186/s12868-021-00653-0

Article

Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System

Jin X, Morro B, T?rresen OK, Moiche V, Solbakken MH, Jakobsen KS, Jentoft S & MacKenzie S (2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Frontiers in Immunology, 11, Art. No.: 609456. https://doi.org/10.3389/fimmu.2020.609456

Article

Cognitive appraisal in fish: stressor predictability modulates the physiological and neurobehavioural stress response in sea bass

Cerqueira M, Millot S, Felix A, Silva T, Oliveira GA, Oliveira CCV, Rey S, MacKenzie S & Oliveira R (2020) Cognitive appraisal in fish: stressor predictability modulates the physiological and neurobehavioural stress response in sea bass. Proceedings of the Royal Society B: Biological Sciences, 287 (1923), Art. No.: 20192922. https://doi.org/10.1098/rspb.2019.2922

Article

Mycotoxins in aquaculture: feed and food

Gon?alves RA, Schatzmayr D, Albalat A & Mackenzie S (2020) Mycotoxins in aquaculture: feed and food. Reviews in Aquaculture, 12 (1), pp. 145-175. https://doi.org/10.1111/raq.12310

Article

Effects of different photoperiod regimes on the smoltification and seawater adaptation of seawater-farmed rainbow trout (Oncorhynchus mykiss): Insights from Na+, K+-ATPase activity and transcription of osmoregulation and growth regulation genes

Morro B, Balseiro P, Albalat a, Pedrosa C, Mackenzie S, Nakamura S, Shimizu M, Nilsen TO, Sveier H, Ebbesson LO & Handeland SO (2019) Effects of different photoperiod regimes on the smoltification and seawater adaptation of seawater-farmed rainbow trout (Oncorhynchus mykiss): Insights from Na+, K+-ATPase activity and transcription of osmoregulation and growth regulation genes. Aquaculture, 507, pp. 282-292. https://doi.org/10.1016/j.aquaculture.2019.04.039

Conference Paper (published)

Assessing the Influence of Individual Variation in Coping Styles on Swimming Performance in Zebrafish (Danio Rerio)

Rey Planellas S, Mackenzie S & Planas J (2018) Assessing the Influence of Individual Variation in Coping Styles on Swimming Performance in Zebrafish (Danio Rerio) [Swimming performance in zebrafish]. In: FitFish Annual Conference 2016. FITFISH EU cost action, Belgrade, Serbia, 22.04.2016-22.04.2016. FitFish, p. 34. https://www.fitfish.eu/upload_mm/c/5/8/bc3a7541-dd20-4aa4-bbe4-f074612af4cb_FITFISH%20annual%20conference%202016.pdf

Article

Extending immunological profiling in the gilthead sea bream, sparus aurata, by enriched cDNA library analysis, microarray design and initial studies upon the inflammatory response to PAMPs

Boltana S, Castellana B, Goetz G, Tort L, Teles M, Mulero V, Novoa B, Figueras A, Goetz FW, Gallardo-Escarate C, Planas JV & MacKenzie S (2017) Extending immunological profiling in the gilthead sea bream, sparus aurata, by enriched cDNA library analysis, microarray design and initial studies upon the inflammatory response to PAMPs. International Journal of Molecular Sciences, 18 (2), Art. No.: 317. https://doi.org/10.3390/ijms18020317

Article

Behavioural fever in zebrafish larvae

Rey S, Moiche Vega AV, Boltana S, Teles M & MacKenzie S (2017) Behavioural fever in zebrafish larvae. Developmental and Comparative Immunology, 67, pp. 287-292. https://doi.org/10.1016/j.dci.2016.09.008

Commentary

Stress induced hyperthermia in zebrafish: a reply to Key et al.

Rey S, Huntingford FA, Knowles TG & MacKenzie S (2017) Stress induced hyperthermia in zebrafish: a reply to Key et al.. Commentary on: Key B et al. 2017 Problems with equating thermal preference with ‘emotional fever’ and sentience: comment on ‘Fish can show emotional fever: stress-induced hyperthermia in zebrafish’ by Rey et al. (2015). Proc. R. Soc. B 284, 20160681. (doi:10.1098/rspb.2016.0681). Proceedings of the Royal Society B: Biological Sciences, 284 (1847), Art. No.: 20162124. https://doi.org/10.1098/rspb.2016.2124

Article

The response of fish to immunostimulant diets

Vallejos-Vidal E, Reyes-López F, Teles M & MacKenzie S (2016) The response of fish to immunostimulant diets. Fish and Shellfish Immunology, 56, pp. 34-69. https://doi.org/10.1016/j.fsi.2016.06.028

Book Chapter

An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming

Torresen OK, Rise ML, Jin X, Star B, MacKenzie S, Jakobsen KS, Nederbragt AJ & Jentoft S (2016) An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming. In: MacKenzie S & Jentoft S (eds.) Genomics in aquaculture. Cambridge, MA, USA: Elsevier, pp. 45-72. http://store.elsevier.com/Genomics-in-Aquaculture/isbn-9780128014189/

Edited Book

Genomics in Aquaculture

MacKenzie S & Jentoft S (eds.) (2016) Genomics in Aquaculture. Cambridge, MA, USA: Academic Press. http://store.elsevier.com/Genomics-in-Aquaculture/isbn-9780128014189/

Article

Investigating the underlying mechanisms of temperature-related skin diseases in Atlantic salmon, Salmo salar L., as measured by quantitative histology, skin transcriptomics and composition

Jensen L, Boltana S, Obach A, McGurk C, Waagbo R & MacKenzie S (2015) Investigating the underlying mechanisms of temperature-related skin diseases in Atlantic salmon, Salmo salar L., as measured by quantitative histology, skin transcriptomics and composition. Journal of Fish Diseases, 38 (11), pp. 977-992. https://doi.org/10.1111/jfd.12314

Article

Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV)

Reyes-Lopez F, Romeo JS, Vallejos-Vidal E, Reyes-Cerpa S, Sandino AM, Tort L, MacKenzie S & Imarai M (2015) Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV). Developmental and Comparative Immunology, 53 (1), pp. 210-221. https://doi.org/10.1016/j.dci.2015.06.017

Article

Fish can show emotional fever: stress-induced hyperthermia in zebrafish

Rey S, Huntingford FA, Bolta?a S, Vargas R, Knowles TG & MacKenzie S (2015) Fish can show emotional fever: stress-induced hyperthermia in zebrafish. Proceedings of the Royal Society B: Biological Sciences, 282 (1819), Art. No.: 20152266. https://doi.org/10.1098/rspb.2015.2266

Article

Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules

Garcia-Valtanen P, Ortega-Villaizan MdM, Martinez-Lopez A, Medina-Gali R, Perez L, MacKenzie S, Figueras A, Coll JM & Estepa A (2014) Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy, 10 (9), pp. 1666-1680. https://doi.org/10.4161/auto.29557

Article

Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead seabream)

Boltana S, Tridico R, Teles M, MacKenzie S & Tort L (2014) Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead seabream). Fish and Shellfish Immunology, 39 (2), pp. 475-482. https://doi.org/10.1016/j.fsi.2014.06.003

Article

Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function

Rey S, Boltana S, Vargas R, Roher N & MacKenzie S (2013) Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function. Molecular Ecology, 22 (24), pp. 6100-6115. https://doi.org/10.1111/mec.12556

Article

Behavioural fever is a synergic signal amplifying the innate immune response

Boltana S, Rey S, Roher N, Vargas R, Huerta M, Huntingford FA, Goetz FW, Moore J, Garcia-Valtanen P, Estepa A & MacKenzie S (2013) Behavioural fever is a synergic signal amplifying the innate immune response. Proceedings of the Royal Society B: Biological Sciences, 280 (1766), Art. No.: 20131381. https://doi.org/10.1098/rspb.2013.1381

Article

Abundance of the Quorum-Sensing Factor Ax21 in Four Strains of Stenotrophomonas maltophilia Correlates with Mortality Rate in a New Zebrafish Model of Infection

Ferrer-Navarro M, Planell R, Yero D, Mongiardini E, Torrent G, Huedo P, Martinez P, Roher N, MacKenzie S, Gibert I & Daura X (2013) Abundance of the Quorum-Sensing Factor Ax21 in Four Strains of Stenotrophomonas maltophilia Correlates with Mortality Rate in a New Zebrafish Model of Infection. PLoS ONE, 8 (6), Art. No.: e67207. https://doi.org/10.1371/journal.pone.0067207

Book Chapter

Developments in genomics relevant to disease control in aquaculture

MacKenzie S, Boltana S, Novoa B, Figueras A & Goetz FW (2012) Developments in genomics relevant to disease control in aquaculture. In: Austin B (ed.) Infectious Disease in Aquaculture: Prevention and Control. Woodhead Publishing Series in Food Science, Technology and Nutrition, 231. Cambridge: Woodhead Printing, pp. 331-352. http://www.sciencedirect.com/science/article/pii/B9780857090164500131; https://doi.org/10.1533/9780857095732.3.331

Article

Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of senegalese sole (Solea senegalensis)

Norambuena F, MacKenzie S, Bell JG, Callol A, Estevez A & Duncan N (2012) Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of senegalese sole (Solea senegalensis). General and Comparative Endocrinology, 177 (2), pp. 256-262. https://doi.org/10.1016/j.ygcen.2012.04.009

Article

Corrigendum to "Identification of genes involved in immune response of Atlantic salmon (Salmo salar) to IPN virus infection, using expressed sequence tags (EST) analysis" [Aquaculture 318 (2011) 54-60]

Cepeda V, Cofre C, Gonzalez R, MacKenzie S & Vidal R (2012) Corrigendum to "Identification of genes involved in immune response of Atlantic salmon (Salmo salar) to IPN virus infection, using expressed sequence tags (EST) analysis" [Aquaculture 318 (2011) 54-60]. Aquaculture, 338-341, p. 314. https://doi.org/10.1016/j.aquaculture.2012.01.002

Book Chapter

Culture of Fish Head Kidney Mononuclear Phagocytes and Muscle Satellite Cells: Valuable Models for Aquaculture Biotechnology Research

Goetz FW, Planas JV, Diaz M, Iliev DB & MacKenzie S (2011) Culture of Fish Head Kidney Mononuclear Phagocytes and Muscle Satellite Cells: Valuable Models for Aquaculture Biotechnology Research. In: Fletcher G & Rise M (eds.) Aquaculture Biotechnology. Chichester: Wiley-Blackwell, pp. 207-221. http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0813810280.html; https://doi.org/10.1002/9780470963159.ch13

Article

RNA-Seq Reveals an Integrated Immune Response in Nucleated Erythrocytes

Morera D, Roher N, Ribas L, Balasch JC, Donate C, Callol A, Boltana S, Roberts S, Goetz G, Goetz FW & MacKenzie S (2011) RNA-Seq Reveals an Integrated Immune Response in Nucleated Erythrocytes. PLoS ONE, 6 (10), Art. No.: e26998. https://doi.org/10.1371/journal.pone.0026998

Article

Changes in complement responses in Gilthead seabream (Sparus aurata) and European seabass (Dicentrarchus labrax) under crowding stress, plus viral and bacterial challenges

Mauri I, Romero A, Acerete L, MacKenzie S, Roher N, Callol A, Cano I, Alvarez MC & Tort L (2011) Changes in complement responses in Gilthead seabream (Sparus aurata) and European seabass (Dicentrarchus labrax) under crowding stress, plus viral and bacterial challenges. Fish and Shellfish Immunology, 30 (1), pp. 182-188. https://doi.org/10.1016/j.fsi.2010.10.006

Article

The proinflammatory cytokine tumor necrosis factor-α increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6

Roher N, Samokhvalov V, Diaz M, MacKenzie S, Klip A & Planas JV (2008) The proinflammatory cytokine tumor necrosis factor-α increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6. Endocrinology, 149 (4), pp. 1880-1889. https://doi.org/10.1210/en.2007-1045

Article

Reproductive consequences of an immune challenge during the preovulatory period in trout: Possible mediatory role of tumor necrosis factor α

Bonnet E, Crespo D, Roher N, MacKenzie S, Goetz FW, Bobe J & Planas JV (2008) Reproductive consequences of an immune challenge during the preovulatory period in trout: Possible mediatory role of tumor necrosis factor α. Cybium, 32 (2 Supplement), pp. 148-150. http://sfi.mnhn.fr/cybium/numeros/2008/322%20suppl%20ISRPF/06-Gametogenesis%20and%20gamete%20biology/63-Planas%20O48.pdf

Article

Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation

MacKenzie S, Balasch JC, Novoa B, Ribas L, Roher N, Krasnov A & Figueras A (2008) Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation. BMC Genomics, 9, Art. No.: 141. https://doi.org/10.1186/1471-2164-9-141

Article

Cloning of the glucocorticoid receptor (GR) in gilthead seabream (Sparus aurata). Differential expression of GR and immune genes in gilthead seabream after an immune challenge

Acerete L, Balasch JC, Castellana B, Redruello B, Roher N, Canario AVM, Planas JV, MacKenzie S & Tort L (2007) Cloning of the glucocorticoid receptor (GR) in gilthead seabream (Sparus aurata). Differential expression of GR and immune genes in gilthead seabream after an immune challenge. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 148 (1), pp. 32-43. https://doi.org/10.1016/j.cbpb.2007.04.015

See all 118 outputs